Human plasma concentrations of cytochrome P450 probes extrapolated from pharmacokinetics in cynomolgus monkeys using physiologically based pharmacokinetic modeling

Xenobiotica ◽

10.3109/00498254.2015.1028511 ◽

2015 ◽

Vol 45 (10) ◽

pp. 881-886 ◽

Author(s):

Satomi Shida ◽

Masahiro Utoh ◽

Norie Murayama ◽

Makiko Shimizu ◽

Yasuhiro Uno ◽

...

Keyword(s):

Cytochrome P450 ◽

Human Plasma ◽

Plasma Concentrations ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Cynomolgus Monkeys ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Human plasma concentrations of cytochrome P450 probe cocktails extrapolated from pharmacokinetics in mice transplanted with human hepatocytes and from pharmacokinetics in common marmosets using physiologically based pharmacokinetic modeling

Xenobiotica ◽

10.3109/00498254.2016.1147102 ◽

2016 ◽

Vol 46 (12) ◽

pp. 1049-1055 ◽

Author(s):

Masahiro Utoh ◽

Hiroshi Suemizu ◽

Marina Mitsui ◽

Mirai Kawano ◽

Akiko Toda ◽

...

Keyword(s):

Cytochrome P450 ◽

Human Plasma ◽

Plasma Concentrations ◽

Pharmacokinetic Modeling ◽

Human Hepatocytes ◽

Physiologically Based Pharmacokinetic Modeling ◽

Common Marmosets ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Human plasma concentrations of five cytochrome P450 probes extrapolated from pharmacokinetics in dogs and minipigs using physiologically based pharmacokinetic modeling

Xenobiotica ◽

10.3109/00498254.2015.1118650 ◽

2015 ◽

Vol 46 (9) ◽

pp. 759-764 ◽

Author(s):

Satomi Shida ◽

Hiroshi Yamazaki

Keyword(s):

Cytochrome P450 ◽

Human Plasma ◽

Plasma Concentrations ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Human Plasma Concentrations of Tolbutamide and Acetaminophen Extrapolated from in vivo Animal Pharmacokinetics Using in vitro Human Hepatic Clearances and Simple Physiologically Based Pharmacokinetic Modeling for Radio-labeled Microdose Clinical Studies

RADIOISOTOPES ◽

10.3769/radioisotopes.64.509 ◽

2015 ◽

Vol 64 (8) ◽

pp. 509-519 ◽

Author(s):

Hiroshi YAMAZAKI ◽

Eriko KUNIKANE ◽

Sayako NISHIYAMA ◽

Norie MURAYAMA ◽

Makiko SHIMIZU ◽

...

Keyword(s):

Human Plasma ◽

Clinical Studies ◽

Plasma Concentrations ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Animal Pharmacokinetics

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Human plasma concentrations of herbicidal carbamate molinate extrapolated from the pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and physiologically based pharmacokinetic modeling

Regulatory Toxicology and Pharmacology ◽

10.1016/j.yrtph.2014.06.028 ◽

2014 ◽

Vol 70 (1) ◽

pp. 214-221 ◽

Author(s):

Masanao Yamashita ◽

Hiroshi Suemizu ◽

Norie Murayama ◽

Sayako Nishiyama ◽

Makiko Shimizu ◽

...

Keyword(s):

Human Plasma ◽

Plasma Concentrations ◽

Pharmacokinetic Modeling ◽

Chimeric Mice ◽

Physiologically Based Pharmacokinetic Modeling ◽

In Vivo Experiments ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Physiologically Based Pharmacokinetic Modeling of Transporter-Mediated Hepatic Clearance and Liver Partitioning of OATP and OCT Substrates in Cynomolgus Monkeys

The AAPS Journal ◽

10.1208/s12248-017-0151-z ◽

2017 ◽

Vol 19 (6) ◽

pp. 1878-1889 ◽

Author(s):

Bridget L. Morse ◽

Jamus G. MacGuire ◽

Anthony M. Marino ◽

Yue Zhao ◽

Maxine Fox ◽

...

Keyword(s):

Hepatic Clearance ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Cynomolgus Monkeys ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Plasma concentrations of melengestrol acetate in humans extrapolated from the pharmacokinetics established in in vivo experiments with rats and chimeric mice with humanized liver and physiologically based pharmacokinetic modeling

Regulatory Toxicology and Pharmacology ◽

10.1016/j.yrtph.2013.01.008 ◽

2013 ◽

Vol 65 (3) ◽

pp. 316-324 ◽

Author(s):

Ai Tsukada ◽

Hiroshi Suemizu ◽

Norie Murayama ◽

Ryohji Takano ◽

Makiko Shimizu ◽

...

Keyword(s):

Plasma Concentrations ◽

Pharmacokinetic Modeling ◽

Chimeric Mice ◽

Physiologically Based Pharmacokinetic Modeling ◽

In Vivo Experiments ◽

Physiologically Based Pharmacokinetic ◽

Melengestrol Acetate ◽

Physiologically Based

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Evaluation of Cytochrome P450 3A4-Mediated Drug–Drug Interaction Potential for Cobimetinib Using Physiologically Based Pharmacokinetic Modeling and Simulation

Clinical Pharmacokinetics ◽

10.1007/s40262-016-0412-5 ◽

2016 ◽

Vol 55 (11) ◽

pp. 1435-1445 ◽

Author(s):

Nageshwar R. Budha ◽

Tao Ji ◽

Luna Musib ◽

Steve Eppler ◽

Mark Dresser ◽

...

Keyword(s):

Cytochrome P450 ◽

Drug Interaction ◽

Modeling And Simulation ◽

Interaction Potential ◽

Pharmacokinetic Modeling ◽

Cytochrome P450 3A4 ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Drug Drug Interaction

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Predicting the Effect of Cytochrome P450 Inhibitors on Substrate Drugs: Analysis of Physiologically Based Pharmacokinetic Modeling Submissions to the US Food and Drug Administration

Clinical Pharmacokinetics ◽

10.1007/s40262-014-0188-4 ◽

2014 ◽

Vol 54 (1) ◽

pp. 117-127 ◽

Author(s):

Christian Wagner ◽

Yuzhuo Pan ◽

Vicky Hsu ◽

Joseph A. Grillo ◽

Lei Zhang ◽

...

Keyword(s):

Cytochrome P450 ◽

Drug Administration ◽

Food And Drug Administration ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

The Us ◽

Physiologically Based ◽

Drugs Analysis ◽

P450 Inhibitors

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Physiologically-Based Pharmacokinetic Modeling and Simulation to Assess Potential Cytochrome P450 3A4 and Transporter-Mediated Drug−drug Interactions with Prucalopride as Victim

10.26226/morressier.57d6b2b9d462b8028d88ea6f ◽

2016 ◽

Author(s):

Aiqun Li

Keyword(s):

Cytochrome P450 ◽

Drug Interactions ◽

Modeling And Simulation ◽

Pharmacokinetic Modeling ◽

Cytochrome P450 3A4 ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Pharmacokinetic Modeling And Simulation

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Toward precision medicine in pediatric population using cytochrome P450 phenotyping approaches and physiologically based pharmacokinetic modeling

Pediatric Research ◽

10.1038/s41390-019-0609-z ◽

2019 ◽

Vol 87 (3) ◽

pp. 441-449 ◽

Author(s):

Gaëlle Magliocco ◽

Frédérique Rodieux ◽

Jules Desmeules ◽

Caroline Flora Samer ◽

Youssef Daali

Keyword(s):

Cytochrome P450 ◽

Precision Medicine ◽

Pediatric Population ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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