Toward precision medicine in pediatric population using cytochrome P450 phenotyping approaches and physiologically based pharmacokinetic modeling

Pediatric Research ◽

10.1038/s41390-019-0609-z ◽

2019 ◽

Vol 87 (3) ◽

pp. 441-449 ◽

Author(s):

Gaëlle Magliocco ◽

Frédérique Rodieux ◽

Jules Desmeules ◽

Caroline Flora Samer ◽

Youssef Daali

Keyword(s):

Cytochrome P450 ◽

Precision Medicine ◽

Pediatric Population ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Human plasma concentrations of cytochrome P450 probe cocktails extrapolated from pharmacokinetics in mice transplanted with human hepatocytes and from pharmacokinetics in common marmosets using physiologically based pharmacokinetic modeling

Xenobiotica ◽

10.3109/00498254.2016.1147102 ◽

2016 ◽

Vol 46 (12) ◽

pp. 1049-1055 ◽

Author(s):

Masahiro Utoh ◽

Hiroshi Suemizu ◽

Marina Mitsui ◽

Mirai Kawano ◽

Akiko Toda ◽

...

Keyword(s):

Cytochrome P450 ◽

Human Plasma ◽

Plasma Concentrations ◽

Pharmacokinetic Modeling ◽

Human Hepatocytes ◽

Physiologically Based Pharmacokinetic Modeling ◽

Common Marmosets ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Evaluation of Cytochrome P450 3A4-Mediated Drug–Drug Interaction Potential for Cobimetinib Using Physiologically Based Pharmacokinetic Modeling and Simulation

Clinical Pharmacokinetics ◽

10.1007/s40262-016-0412-5 ◽

2016 ◽

Vol 55 (11) ◽

pp. 1435-1445 ◽

Author(s):

Nageshwar R. Budha ◽

Tao Ji ◽

Luna Musib ◽

Steve Eppler ◽

Mark Dresser ◽

...

Keyword(s):

Cytochrome P450 ◽

Drug Interaction ◽

Modeling And Simulation ◽

Interaction Potential ◽

Pharmacokinetic Modeling ◽

Cytochrome P450 3A4 ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Drug Drug Interaction

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Predicting the Effect of Cytochrome P450 Inhibitors on Substrate Drugs: Analysis of Physiologically Based Pharmacokinetic Modeling Submissions to the US Food and Drug Administration

Clinical Pharmacokinetics ◽

10.1007/s40262-014-0188-4 ◽

2014 ◽

Vol 54 (1) ◽

pp. 117-127 ◽

Author(s):

Christian Wagner ◽

Yuzhuo Pan ◽

Vicky Hsu ◽

Joseph A. Grillo ◽

Lei Zhang ◽

...

Keyword(s):

Cytochrome P450 ◽

Drug Administration ◽

Food And Drug Administration ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

The Us ◽

Physiologically Based ◽

Drugs Analysis ◽

P450 Inhibitors

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Physiologically-Based Pharmacokinetic Modeling and Simulation to Assess Potential Cytochrome P450 3A4 and Transporter-Mediated Drug−drug Interactions with Prucalopride as Victim

10.26226/morressier.57d6b2b9d462b8028d88ea6f ◽

2016 ◽

Author(s):

Aiqun Li

Keyword(s):

Cytochrome P450 ◽

Drug Interactions ◽

Modeling And Simulation ◽

Pharmacokinetic Modeling ◽

Cytochrome P450 3A4 ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Pharmacokinetic Modeling And Simulation

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Human plasma concentrations of five cytochrome P450 probes extrapolated from pharmacokinetics in dogs and minipigs using physiologically based pharmacokinetic modeling

Xenobiotica ◽

10.3109/00498254.2015.1118650 ◽

2015 ◽

Vol 46 (9) ◽

pp. 759-764 ◽

Author(s):

Satomi Shida ◽

Hiroshi Yamazaki

Keyword(s):

Cytochrome P450 ◽

Human Plasma ◽

Plasma Concentrations ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Meta-analysis of hepatic cytochrome P450 ontogeny to underwrite the prediction of pediatric pharmacokinetics using physiologically based pharmacokinetic modeling

The Journal of Clinical Pharmacology ◽

10.1002/jcph.585 ◽

2015 ◽

Vol 56 (3) ◽

pp. 266-283 ◽

Author(s):

Vijay V. Upreti ◽

Jan L. Wahlstrom

Keyword(s):

Cytochrome P450 ◽

Meta Analysis ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Hepatic Cytochrome

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Human plasma concentrations of cytochrome P450 probes extrapolated from pharmacokinetics in cynomolgus monkeys using physiologically based pharmacokinetic modeling

Xenobiotica ◽

10.3109/00498254.2015.1028511 ◽

2015 ◽

Vol 45 (10) ◽

pp. 881-886 ◽

Author(s):

Satomi Shida ◽

Masahiro Utoh ◽

Norie Murayama ◽

Makiko Shimizu ◽

Yasuhiro Uno ◽

...

Keyword(s):

Cytochrome P450 ◽

Human Plasma ◽

Plasma Concentrations ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Cynomolgus Monkeys ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Unraveling pleiotropic effects of rifampicin by using physiologically based pharmacokinetic modeling: Assessing the induction magnitude of P‐glycoprotein–cytochrome P450 3A4 dual substrates

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.12717 ◽

2021 ◽

Author(s):

Xian Pan ◽

Shinji Yamazaki ◽

Sibylle Neuhoff ◽

Mian Zhang ◽

Venkatesh Pilla Reddy

Keyword(s):

Cytochrome P450 ◽

Pharmacokinetic Modeling ◽

Pleiotropic Effects ◽

Cytochrome P450 3A4 ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

P Glycoprotein ◽

Physiologically Based

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Assessment of cytochrome P450-mediated drug-drug interaction potential of orteronel and exposure changes in patients with renal impairment using physiologically based pharmacokinetic modeling and simulation

Biopharmaceutics & Drug Disposition ◽

10.1002/bdd.1919 ◽

2014 ◽

Vol 35 (9) ◽

pp. 543-552 ◽

Author(s):

Chuang Lu ◽

Ajit Suri ◽

Wen Chyi Shyu ◽

Shimoga Prakash

Keyword(s):

Cytochrome P450 ◽

Drug Interaction ◽

Renal Impairment ◽

Modeling And Simulation ◽

Interaction Potential ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Drug Drug Interaction

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Physiologically-based pharmacokinetic modeling for mirabegron: a multi-elimination pathway mediated by cytochrome P450 3A4, uridine 5'-diphosphate-glucuronosyltransferase 2B7, and butyrylcholinesterase

Xenobiotica ◽

10.1080/00498254.2018.1523489 ◽

2018 ◽

Vol 49 (8) ◽

pp. 912-921 ◽

Author(s):

Kentaro Konishi ◽

Tsuyoshi Minematsu ◽

Yasuhisa Nagasaka ◽

Kenji Tabata

Keyword(s):

Cytochrome P450 ◽

Pharmacokinetic Modeling ◽

Cytochrome P450 3A4 ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Elimination Pathway

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