HIV treatment adherence strategy: better viral control at modest cost

Background.Criteria for antiretroviral treatment (ART) were adjusted to enable early HIV treatment for people living HIV/AIDS (PLHIV) in China in recent years. This study aims to determine how pretreatment waiting time after HIV confirmation affects subsequent adherence and outcomes over the course of treatment.Methods.A retrospective observational cohort study was conducted using treatment data from PLHIV in Yuxi, China, between January 2004 and December 2015.Results.Of 1,663 participants, 348 were delayed testers and mostly initiated treatment within 28 days. In comparison, 1,315 were nondelayed testers and the median pretreatment waiting time was 599 days, but it significantly declined over the study period. Pretreatment CD4 T-cell count drop (every 100 cells/mm3) contributed slowly in CD4 recovery after treatment initiation (8% less,P<0.01) and increased the risk of poor treatment adherence by 15% (ARR = 1.15, 1.08–1.25). Every 100 days of extensive pretreatment waiting time increased rates of loss to follow-up by 20% (ARR = 1.20, 1.07–1.29) and mortality rate by 11% (ARR = 1.11, 1.06–1.21), based on multivariable Cox regression.Conclusion.Long pretreatment waiting time in PLHIV can lead to higher risk of poor treatment adherence and HIV-related mortality. Current treatment guidelines should be updated to provide ART promptly.

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HIV Treatment Adherence in Women Living With HIV/AIDS: Research Based on the Information-Motivation-Behavioral Skills Model of Health Behavior

Journal of the Association of Nurses in AIDS Care ◽

10.1016/s1055-3290(06)60217-3 ◽

2001 ◽

Vol 12 (4) ◽

pp. 58-67 ◽

Cited By ~ 69

Author(s):

Seth C. Kalichman ◽

David Rompa ◽

Kari DiFonzo ◽

Dolores Simpson ◽

James Austin ◽

...

Keyword(s):

Health Behavior ◽

Treatment Adherence ◽

Hiv Treatment ◽

Behavioral Skills ◽

Women Living With Hiv ◽

Aids Research ◽

Living With Hiv ◽

Hiv Aids

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Treatment Strategy: Role of Enfuvirtide in Managing Treatment-Limiting Side Effects

Canadian Journal of Infectious Diseases and Medical Microbiology ◽

10.1155/2007/456437 ◽

2007 ◽

Vol 18 (suppl a) ◽

pp. 8A-9A

Author(s):

Christos Tsoukas

Keyword(s):

Side Effects ◽

Treatment Strategy ◽

Drug Class ◽

Hiv Treatment ◽

Entry Inhibitor ◽

Viral Control ◽

Treatment History ◽

Lengthy Treatment ◽

Cessation Of Treatment

Side effects can limit the options available to physicians for the treatment of HIV infection. Management of these side effects is essential, to avoid cessation of treatment. The entry inhibitor enfuvirtide can be useful as one of three active agents in an HIV treatment regimen as a way to both reduce treatment-limiting side effects and provide an efficacious agent for viral control. In the present case, the patient had a problematic and lengthy treatment history, with numerous concomitant conditions. His latest regimen, which includes an agent in a new drug class (enfuvirtide), has maintained HIV suppression while minimizing toxicity.

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Alcohol Use, HIV Treatment Adherence, and Sexual Risk Among People with a History of Injecting Drug Use in Vietnam

AIDS and Behavior ◽

10.1007/s10461-017-1860-0 ◽

2017 ◽

Vol 21 (S2) ◽

pp. 167-173 ◽

Cited By ~ 5

Author(s):

Li Li ◽

Sitong Luo ◽

Chiao-Wen Lan ◽

Chunqing Lin ◽

Le Anh Tuan ◽

...

Keyword(s):

Alcohol Use ◽

Drug Use ◽

Sexual Risk ◽

Treatment Adherence ◽

Injecting Drug Use ◽

Hiv Treatment ◽

History Of

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Psychosocial interventions to improve HIV treatment adherence: A systematic review

10.31234/osf.io/a5pcj ◽

2021 ◽

Author(s):

Stefanella Costa-Cordella ◽

Alejandra Rossi ◽

Aitana Grasso-Cladera ◽

Javiera Duarte ◽

Claudia P. Cortes

Keyword(s):

Systematic Review ◽

Treatment Adherence ◽

Peer Support ◽

Psychosocial Interventions ◽

Hiv Treatment ◽

People Living With Hiv ◽

Individual Counselling ◽

Suboptimal Adherence ◽

Study Designs

Introduction: The problem of suboptimal adherence to antiretroviral treatment (ART) can be overcome through multidisciplinary management that includes evidence-based psychosocial interventions. Existing reviews focus only on randomized controlled trials, overlooking valuable interventions whose evidence comes from different study designs. This review aimed to synthesize the current state of the art in psychological interventions for ART adherence, integrating studies with a variety of research designs.Methods: We conducted a systematic review following PRISMA guidelines. We searched five databases for articles reporting a psychosocial intervention to improve treatment adherence for people living with HIV. The quality of each study was analyzed, and the data summarized using a narrative synthesis method.Results and discussion: Twenty-six articles were identified for inclusion. Individual counselling was the most common intervention, followed by peer-support based interventions delivered virtually or in person. Most interventions mixed different strategies, combining technology with individual counselling and peer support. It is important to note that the quality of evidence was not dependent on the study design.Conclusion: While the evidence requires further advancement, the review provides insight into which psychosocial interventions are helpful in improving ART treatment adherence.

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