The role of PET radiomic features in prostate cancer: a systematic review

Author(s):  
Natale Quartuccio ◽  
Maurizio Marrale ◽  
Riccardo Laudicella ◽  
Pierpaolo Alongi ◽  
Massimiliano Siracusa ◽  
...  
Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 552
Author(s):  
Salam Awenat ◽  
Arnoldo Piccardo ◽  
Patricia Carvoeiras ◽  
Giovanni Signore ◽  
Luca Giovanella ◽  
...  

Background: The use of prostate-specific membrane antigen (PSMA)-targeted agents for staging prostate cancer (PCa) patients using positron emission tomography/computed tomography (PET/CT) is increasing worldwide. We performed a systematic review on the role of 18F-PSMA-1007 PET/CT in PCa staging to provide evidence-based data in this setting. Methods: A comprehensive computer literature search of PubMed/MEDLINE and Cochrane Library databases for studies using 18F-PSMA-1007 PET/CT in PCa staging was performed until 31 December 2020. Eligible articles were selected and relevant information was extracted from the original articles by two authors independently. Results: Eight articles (369 patients) evaluating the role of 18F-PSMA-1007 PET/CT in PCa staging were selected. These studies were quite heterogeneous, but, overall, they demonstrated a good diagnostic accuracy of 18F-PSMA-1007 PET/CT in detecting PCa lesions at staging. Overall, higher primary PCa aggressiveness was associated with higher 18F-PSMA-1007 uptake. When compared with other radiological and scintigraphic imaging methods, 18F-PSMA-1007 PET/CT had superior sensitivity in detecting metastatic disease and the highest inter-reader agreement. 18F-PSMA-1007 PET/CT showed similar results in terms of diagnostic accuracy for PCa staging compared with PET/CT with other PSMA-targeted tracers. Dual imaging with multi-parametric magnetic resonance imaging and 18F-PSMA-1007 PET/CT may improve staging of primary PCa. Notably, 18F-PSMA-1007-PET/CT may detect metastatic disease in a significant number of patients with negative standard imaging. Conclusions: 18F-PSMA-1007 PET/CT demonstrated a good accuracy in PCa staging, with similar results compared with other PSMA-targeted radiopharmaceuticals. This method could substitute bone scintigraphy and conventional abdominal imaging for PCa staging. Prospective multicentric studies are needed to confirm these findings.


2016 ◽  
Vol Volume 10 ◽  
pp. 2435-2442 ◽  
Author(s):  
Yun Ye ◽  
Su-Liang Li ◽  
Yao Wang ◽  
Yao Yang ◽  
Juan Wang ◽  
...  

2019 ◽  
Vol 2 (3) ◽  
pp. 294-301 ◽  
Author(s):  
Eugenio Ventimiglia ◽  
Thomas Seisen ◽  
Firas Abdollah ◽  
Alberto Briganti ◽  
Valerie Fonteyne ◽  
...  

2017 ◽  
Vol 33 (1) ◽  
pp. 10-21 ◽  
Author(s):  
Barbara Muoio ◽  
Mariarosa Pascale ◽  
Enrico Roggero

In this systematic review, we evaluated the value of serum concentrations of neuron-specific enolase (NSE) in patients with prostate cancer (PCa) in order to clarify the possible role of NSE in the diagnosis, management, treatment and monitoring of PCa. A comprehensive search of the recent literature was conducted to find relevant data on the role of NSE in PCa. Two hundred and eighty-two records were revealed, and 19 articles including 1,772 patients with PCa (either confirmed or suspected) were selected. After reviewing the articles, the major result was that elevated serum NSE appears to correlate with prognosis in advanced PCa, particularly in patients with progressive and metastatic castration-resistant PCa. Based on the existing literature, the role of serum NSE in PCa patients should be further evaluated.


2016 ◽  
Vol 69 (5) ◽  
pp. 802-820 ◽  
Author(s):  
Roderick C.N. van den Bergh ◽  
Niels J. van Casteren ◽  
Thomas van den Broeck ◽  
Eve R. Fordyce ◽  
William K.M. Gietzmann ◽  
...  

2014 ◽  
Vol 66 (2) ◽  
pp. 191-199 ◽  
Author(s):  
Georgios Gakis ◽  
Stephen A. Boorjian ◽  
Alberto Briganti ◽  
Steven Joniau ◽  
Guram Karazanashvili ◽  
...  

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