scholarly journals Donor-Derived Cell-Free DNA for Acute Rejection Monitoring in Heart and Lung Transplantation

2021 ◽  
Author(s):  
Michael Keller ◽  
Sean Agbor-Enoh
Keyword(s):  
Acute Rejection ◽  
Lung Transplantation ◽  
Cell Free Dna ◽  
Free Dna

Cell Free DNA Levels in Patients with Acute Rejection after Lung Transplantation

2021 ◽  
Vol 40 (4) ◽  
pp. S367
Author(s):  
I. Timofte ◽  
M. Keller ◽  
A. Varghese ◽  
D. Levine ◽  
S. Aryal ◽  
...  
Keyword(s):  
Acute Rejection ◽  
Lung Transplantation ◽  
Cell Free Dna ◽  
Free Dna

scholarly journals Cell-Free DNA to Monitor Immunosuppression Adequacy in Lung Transplantation

2021 ◽  
Vol 40 (4) ◽  
pp. S62
Author(s):  
A. Charya ◽  
M. Jang ◽  
C. Mutebi ◽  
H. Luikart ◽  
P. Shah ◽  
...  
Keyword(s):  
Lung Transplantation ◽  
Cell Free Dna ◽  
Free Dna

scholarly journals The use of plasma donor-derived, cell-free DNA to monitor acute rejection after kidney transplantation

2019 ◽  
Vol 35 (4) ◽  
pp. 714-721 ◽  
Author(s):  
Els M Gielis ◽  
Kristien J Ledeganck ◽  
Amélie Dendooven ◽  
Pieter Meysman ◽  
Charlie Beirnaert ◽  
...  
Keyword(s):  
Acute Rejection ◽  
Serum Creatinine ◽  
Characteristic Curve ◽  
Area Under The Curve ◽  
Threshold Value ◽  
Nucleotide Polymorphisms ◽  
Kidney Transplant Recipients ◽  
Cell Free Dna ◽  
Free Dna ◽  
Set Up

Abstract Background After transplantation, cell-free deoxyribonucleic acid (DNA) derived from the donor organ (ddcfDNA) can be detected in the recipient’s circulation. We aimed to investigate the role of plasma ddcfDNA as biomarker for acute kidney rejection. Methods From 107 kidney transplant recipients, plasma samples were collected longitudinally after transplantation (Day 1 to 3 months) within a multicentre set-up. Cell-free DNA from the donor was quantified in plasma as a fraction of the total cell-free DNA by next generation sequencing using a targeted, multiplex polymerase chain reaction-based method for the analysis of single nucleotide polymorphisms. Results Increases of the ddcfDNA% above a threshold value of 0.88% were significantly associated with the occurrence of episodes of acute rejection (P = 0.017), acute tubular necrosis (P = 0.011) and acute pyelonephritis (P = 0.032). A receiver operating characteristic curve analysis revealed an equal area under the curve of the ddcfDNA% and serum creatinine of 0.64 for the diagnosis of acute rejection. Conclusions Although increases in plasma ddcfDNA% are associated with graft injury, plasma ddcfDNA does not outperform the diagnostic capacity of the serum creatinine in the diagnosis of acute rejection.

Response by Shah et al to Letter Regarding Article, “Cell-Free DNA to Detect Heart Allograft Acute Rejection”

Circulation ◽  
2021 ◽  
Vol 144 (10) ◽  
Author(s):  
Palak Shah ◽  
Sean Agbor-Enoh ◽  
Ilker Tunc ◽  
Steven Hsu ◽  
Stuart Russell ◽  
...  
Keyword(s):  
Acute Rejection ◽  
Cell Free Dna ◽  
Heart Allograft ◽  
Free Dna

Cheaper and Faster Analysis of Donor-Derived Cell-Free DNA in Children after Heart and Lung Transplantation; Validation of a New Assay

2020 ◽  
Vol 39 (4) ◽  
pp. S67-S68
Author(s):  
D. Ellershaw ◽  
E. Preka ◽  
N. Chandler ◽  
H. Ahlfors ◽  
H. Spencer ◽  
...  
Keyword(s):  
Lung Transplantation ◽  
Cell Free Dna ◽  
Free Dna

Donor-Derived Cell-Free DNA as Minimally Invasive Tool to Diagnose Acute Rejection after Kidney Transplantation

2018 ◽  
Vol 102 ◽  
pp. S689
Author(s):  
Karin Boer ◽  
Carla C Baan ◽  
Nadine van Donk ◽  
Evert de Jonge ◽  
Marian C Clahsen-van Groningen ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Acute Rejection ◽  
Minimally Invasive ◽  
Cell Free Dna ◽  
Free Dna
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