Effects of short- and long-term neurostimulation (tDCS) on Alzheimer’s disease patients: two randomized studies

2020 ◽  
Author(s):  
Antonio Gangemi ◽  
Barbara Colombo ◽  
Rosa Angela Fabio
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Randomized Studies ◽  
Short And Long Term

scholarly journals Predictors of Short- and Long-Term Adherence to a Daily Walking Program in Persons With Alzheimer’s Disease

2010 ◽  
Vol 25 (6) ◽  
pp. 505-512 ◽  
Author(s):  
Susan M. McCurry ◽  
Kenneth C. Pike ◽  
Rebecca G. Logsdon ◽  
Michael V. Vitiello ◽  
Eric B. Larson ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Walking Program ◽  
Short And Long Term

Short- and Long-Term Implicit Memory in Aging and Alzheimer's Disease

2006 ◽  
Vol 13 (3-4) ◽  
pp. 611-635 ◽  
Author(s):  
David B. Mitchell ◽  
Frederick A. Schmitt
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Implicit Memory ◽  
Short And Long Term

Intranasal formulation of erythropoietin (EPO) showed potent protective activity against amyloid toxicity in the Aβ25-35 non-transgenic mouse model of Alzheimer’s disease

2013 ◽  
Vol 27 (11) ◽  
pp. 1044-1057 ◽  
Author(s):  
Tangui Maurice ◽  
Muhammad-Hariri Mustafa ◽  
Catherine Desrumaux ◽  
Emeline Keller ◽  
Gaëlle Naert ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Loss ◽  
Neuroprotective Activity ◽  
Learning Deficits ◽  
Akt Activation ◽  
Amyloid Toxicity ◽  
Model Of Alzheimer’S Disease ◽  
Short And Long Term

Erythropoietin (EPO) promotes neurogenesis and neuroprotection. We here compared the protection induced by two EPO formulations in a rodent model of Alzheimer’s disease (AD): rHu-EPO and a low sialic form, Neuro-EPO. We used the intracerebroventricular administration of aggregated Aβ25-35 peptide, a non-transgenic AD model. rHu-EPO was tested at 125–500 µg/kg intraperitoneally and Neuro-EPO at 62–250 µg/kg intranasally (IN). Behavioural procedures included spontaneous alternation, passive avoidance, water-maze and object recognition, to address spatial and non-spatial, short- and long-term memories. Biochemical markers of Aβ25-35 toxicity in the mouse hippocampus were examined and cell loss in the CA1 layer was determined. rHu-EPO and Neuro-EPO led to a significant prevention of Aβ25-35-induced learning deficits. Both EPO formulations prevented the induction of lipid peroxidation in the hippocampus, showing an antioxidant activity. rHu-EPO (250 µg/kg) or Neuro-EPO (125 µg/kg) prevented the Aβ25-35-induced increase in Bax level, TNFα and IL-1β production and decrease in Akt activation. A significant prevention of the Aβ25-35-induced cell loss in CA1 was also observed. EPO is neuroprotective in the Aβ25-35 AD model, confirming its potential as an endogenous neuroprotection system that could be boosted for therapeutic efficacy. We here identified a new IN formulation of EPO showing high neuroprotective activity. Considering its efficacy, ease and safety, IN Neuro-EPO is a new promising therapeutic agent in AD.

Regional cerebral blood flow in Alzheimer’s disease: Comparison between short and long-term donepezil therapy

2006 ◽  
Vol 20 (6) ◽  
pp. 425-429 ◽  
Author(s):  
Yo Ushuima ◽  
Chio Okuyama ◽  
Satoru Mori ◽  
Takao Kubota ◽  
Takako Nakai ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Short And Long Term

scholarly journals Memory distortion in Alzheimer's disease: Deficient monitoring of short- and long-term memory.

2012 ◽  
Vol 26 (4) ◽  
pp. 509-516 ◽  
Author(s):  
Katherine E. MacDuffie ◽  
Alexandra S. Atkins ◽  
Kristin E. Flegal ◽  
Christopher M. Clark ◽  
Patricia A. Reuter-Lorenz
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Long Term Memory ◽  
Memory Distortion ◽  
Term Memory ◽  
Short And Long Term

scholarly journals Investigation of the short- and long-term effects of donepezil on cognitive function in Alzheimer's disease

2009 ◽  
Vol 9 (1) ◽  
pp. 27-33 ◽  
Author(s):  
Jun INOUE ◽  
Ryoichi HOSHINO ◽  
Hidenori NOJIMA ◽  
Norio OKAMOTO
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Function ◽  
Long Term Effects ◽  
Short And Long Term
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