A clinical prediction score using age at diagnosis and saline infusion test parameters can predict aldosterone-producing adenoma from idiopathic adrenal hyperplasia

2019 ◽  
Vol 43 (3) ◽  
pp. 347-355 ◽  
Author(s):  
H. T. Leung ◽  
Y. C. Woo ◽  
C. H. Y. Fong ◽  
K. C. B. Tan ◽  
E. Y. F. Lau ◽  
...  
Keyword(s):  
Saline Infusion ◽  
Prediction Score ◽  
Age At Diagnosis ◽  
Infusion Test ◽  
Clinical Prediction ◽  
Adrenal Hyperplasia ◽  
Test Parameters ◽  
Aldosterone Producing Adenoma

scholarly journals MON-192 Comparison of the Seated and Recumbent Saline Infusion Test for the Diagnosis of Primary Aldosteronism in Chinese Population

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Dan Zhang ◽  
Tao Chen ◽  
Haoming Tian ◽  
Yuanmei Li ◽  
Dan Mo ◽  
...  
Keyword(s):  
Primary Aldosteronism ◽  
Operating Characteristic ◽  
Saline Infusion ◽  
Youden Index ◽  
Infusion Test ◽  
Subtype Classification ◽  
Aldosterone Producing Adenoma ◽  
Preliminary Study ◽  
Better Than

Abstract Background: None of the diagnostic tests for primary aldosteronism (PA) are ideal according to the current literature. In a preliminary study, the seated saline infusion test (SSIT) was more sensitive than the recumbent saline infusion test (RSIT) for the diagnosis and subtype classification of PA. However, it is unclear whether the SSIT is suitable for Chinese PA patients. Objective: We prospectively investigated the accuracy of the seated saline infusion test (SSIT) in 113 patients with hypertension (including 93 PA and 20 essential hypertension (EH) patients) in the Department of Endocrinology and Metabolism. Approach and Results: Each patient underwent an recumbent saline infusion test (RSIT) and seated saline infusion test (SSIT). The accuracy of the SSIT for a confirmative primary aldosteronism (PA) diagnosis and subtype classification was evaluated and compared with the RSIT. The area under the receiver operating characteristic (ROC) curve (AUC) of aldosterone for the SSIT was significantly greater than that for the RSIT (0.945±0.0199 vs 0.828±0.0404; P<0.05). The ROC analysis showed that the optimal plasma aldosterone cutoff values were 12.94 ng/dl for the SSIT (sensitivity 86.02%, specificity 95%; Youden index (YI)=0.810) and 12.04 ng/dl for the RSIT (sensitivity 83.15%, specificity 57%; Youden index (YI)=0.401). The optimal aldosterone concentration cutoff value for classifying aldosterone-producing adenoma (APA) and idiopathic hyperaldosteronism (IHA) was 18.12 ng/dl for the SSIT (sensitivity 73.5%, specificity 79.5%). No patients experienced adverse events during the SSIT. Conclusions: The SSIT was safe and convenient for PA diagnosis. The accuracy of the SSIT for a confirmatory diagnosis of PA was better than that of the RSIT. The SSIT is a reliable alternative for PA confirmation in Chinese individuals.

scholarly journals Comparison of the Captopril and the Saline Infusion Test for Excluding Aldosterone-Producing Adenoma

Hypertension ◽  
2007 ◽  
Vol 50 (2) ◽  
pp. 424-431 ◽  
Author(s):  
Gian Paolo Rossi ◽  
Anna Belfiore ◽  
Giampaolo Bernini ◽  
Giovambattista Desideri ◽  
Bruno Fabris ◽  
...  
Keyword(s):  
Saline Infusion ◽  
Infusion Test ◽  
Aldosterone Producing Adenoma

Prospective evaluation of the saline infusion test for excluding primary aldosteronism due to aldosterone-producing adenoma

2007 ◽  
Vol 25 (7) ◽  
pp. 1433-1442 ◽  
Author(s):  
Gian Paolo Rossi ◽  
Anna Belfiore ◽  
Giampaolo Bernini ◽  
Giovambattista Desideri ◽  
Bruno Fabris ◽  
...  
Keyword(s):  
Primary Aldosteronism ◽  
Saline Infusion ◽  
Infusion Test ◽  
Prospective Evaluation ◽  
Aldosterone Producing Adenoma

scholarly journals Comparison of the Captopril and the Saline Infusion Test for Excluding Aldosterone-Producing Adenoma

2007 ◽  
Vol 14 (3) ◽  
pp. 145-196
Author(s):  
G P. Rossi ◽  
A Belfiore ◽  
G Bernini ◽  
G Desideri ◽  
B Fabris ◽  
...  
Keyword(s):  
Saline Infusion ◽  
Infusion Test ◽  
Aldosterone Producing Adenoma

Post saline infusion test aldosterone levels indicate severity and outcome in primary aldosteronism

2014 ◽  
Vol 122 (03) ◽  
Author(s):  
M Weigel ◽  
A Riester ◽  
G Hanslik ◽  
K Lang ◽  
S Endres ◽  
...  
Keyword(s):  
Primary Aldosteronism ◽  
Saline Infusion ◽  
Infusion Test

scholarly journals POR polymorphisms are associated with 21 hydroxylase deficiency

2021 ◽  
Author(s):  
F. Pecori Giraldi ◽  
S. Einaudi ◽  
A. Sesta ◽  
F. Verna ◽  
M. Messina ◽  
...  
Keyword(s):  
Clinical Features ◽  
Modifier Genes ◽  
Age At Diagnosis ◽  
Adrenal Hyperplasia ◽  
Phenotype Correlation ◽  
Hydroxylase Deficiency ◽  
Salt Wasting ◽  
Control Subjects ◽  
Younger Age ◽  
21 Hydroxylase Deficiency

Abstract Purpose Genotype–phenotype correlation in congenital 21 hydroxylase deficiency is strong but by no means absolute. Indeed, clinical and hormonal features may vary among patients carrying similar CYP21A2 mutations, suggesting that modifier genes may contribute to the phenotype. Aim of the present study was to evaluate whether polymorphisms in the p450  oxidoreductase (POR) gene may affect clinical features in patients with 21 hydroxylase deficiency Methods Sequencing of the POR gene was performed in 96 patients with 21 hydroxylase deficiency (49 classic, 47 non-classic) and 43 control subjects. Results Prevalence of POR polymorphisms in patients with 21 hydroxylase was comparable to controls and known databases. The rs2228104 polymorphism was more frequently associated with non-classic vs classic 21 hydroxylase deficiency (allelic risk 7.09; 95% C.I. 1.4–29.5, p < 0.05). Classic 21 hydroxylase-deficient carriers of the minor allele in the rs2286822/rs2286823 haplotype presented more frequently the salt-wasting form (allelic risk 1.375; 95% C.I. 1.138–1.137), more severe Prader stage at birth (allelic risk 3.85; 95% C.I. 3.78–3.92), higher ACTH levels, and younger age at diagnosis. Conclusions Polymorphisms in the POR gene are associated with clinical features of 21 hydroxylase deficiency both as regards predisposition to classic vs non-classic forms and severity of classic adrenal hyperplasia.

scholarly journals Saline Infusion Test highly associated with the incidence of cardio- and cerebrovascular events in primary aldosteronism

2017 ◽  
Vol 64 (5) ◽  
pp. 507-513 ◽  
Author(s):  
Reiko Hayashi ◽  
Daisuke Tamada ◽  
Masahiko Murata ◽  
Kosuke Mukai ◽  
Tetsuhiro Kitamura ◽  
...  
Keyword(s):  
Primary Aldosteronism ◽  
Saline Infusion ◽  
Infusion Test ◽  
Cerebrovascular Events
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