No Effect of Transcranial Direct-Current Stimulation to Dorsolateral Prefrontal Cortex on Naturalistic Prospective Memory in Healthy Young and Older Adults

2019 ◽  
Vol 4 (2) ◽  
pp. 211-218
Author(s):  
Nathan S. Rose ◽  
Hannah Thomson ◽  
Matthias Kliegel
Keyword(s):  
Older Adults ◽  
Prefrontal Cortex ◽  
Prospective Memory ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Dorsolateral Prefrontal Cortex ◽  
Direct Current Stimulation ◽  
Dorsolateral Prefrontal

scholarly journals No Evidence for Enhancing Prospective Memory with Anodal Transcranial Direct Current Stimulation across Dorsolateral Prefrontal Cortex

2019 ◽  
Author(s):  
Derek Ellis ◽  
Gene Arnold Brewer ◽  
Memory & Attention Control Laboratory
Keyword(s):  
Working Memory ◽  
Prefrontal Cortex ◽  
Prospective Memory ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Dorsolateral Prefrontal Cortex ◽  
Memory Performance ◽  
Direct Current Stimulation ◽  
Dorsolateral Prefrontal ◽  
Cue Detection

A standard finding in the event-based prospective memory literature is that focal cues are more often detected than nonfocal cues. The multiprocess view of prospective memory accounts for this result by suggesting that dorsolateral prefrontal cortex (DLPFC) mediated executive processes are necessary for nonfocal cue detection while hippocampally mediated spontaneous retrieval processes support detection of focal cues. In agreement with the multiprocess view, previous studies have found that working memory capacity is predictive of prospective memory performance through detection of nonfocal cues, but non-predictive for focal cues. Because the DLPFC is known to support working memory maintenance, we predicted that anodal transcranial direct current stimulation (tDCS) of the DLPFC would increase prospective memory cue detection for nonfocal cues when compared with a sham condition. Critically, we also expected an interaction between prospective memory cue type and stimulation such that anodal stimulation would not influence focal cue detection. Our results replicated the standard effect of improved focal compared to nonfocal cue detection. However, there was no significant effect between the sham and active tDCS conditions. Furthermore, we did not find the expected interaction between cue type and stimulation. Not only do our findings add onto the growing literature of tDCS experiments that failed to find stimulation effects to DLPFC, but it is also one of the first studies to incorporate prospective memory with tDCS.

scholarly journals Transcranial Direct Current Stimulation May Improve Cognitive-Motor Function in Functionally Limited Older Adults

2018 ◽  
Vol 32 (9) ◽  
pp. 788-798 ◽  
Author(s):  
Brad Manor ◽  
Junhong Zhou ◽  
Rachel Harrison ◽  
On-Yee Lo ◽  
Thomas G. Travison ◽  
...  
Keyword(s):  
Older Adults ◽  
Prefrontal Cortex ◽  
Executive Function ◽  
Direct Current ◽  
Dual Task ◽  
Transcranial Direct Current Stimulation ◽  
Dorsolateral Prefrontal Cortex ◽  
Dual Tasking ◽  
Direct Current Stimulation ◽  
Dorsolateral Prefrontal

Objective. To determine the effects of a transcranial direct current stimulation (tDCS) intervention with the anode placed over the left dorsolateral prefrontal cortex (dlPFC) and cathode over the right supraorbital region, on cognition, mobility, and “dual-task” standing and walking in older adults with mild-to-moderate motor and cognitive impairments. Methods. A double-blinded, block-randomized, sham-controlled trial was conducted in 18 nondemented, ambulatory adults aged ⩾65 years with slow walking speed (⩽1.0 m/s) and “executive” dysfunction (Trail Making Test B score ⩽25th percentile of age- and education-matched norms). Interventions included ten 20-minute sessions of tDCS or sham stimulation. Cognition, mobility, and dual-task standing and walking were assessed at baseline, postintervention, and 2 weeks thereafter. Dual tasking was also assessed immediately before and after the first tDCS session. Results. Intervention compliance was high (mean ± SD = 9.5 ± 1.1 sessions) and no unexpected or serious side effects were reported. tDCS, compared with sham, induced improvements in the Montreal Cognitive Assessment total score ( P = .03) and specifically within the executive function subscore of this test ( P = .002), and in several metrics of dual-task standing and walking ( P < .05). Each of these effects persisted for 2 weeks. tDCS had no effect on the Timed Up-and-Go test of mobility or the Geriatric Depression Scale. Those participants who exhibited larger improvements in dual-task standing posture following the first tDCS session exhibited larger cognitive-motor improvements following 2 weeks of tDCS ( P < .04). Interpretation. tDCS intervention designed to stimulate the left dorsolateral prefrontal cortex may improve executive function and dual tasking in older adults with functional limitations.

scholarly journals Influence of Transcranial Direct Current Stimulation on Psychomotor Symptoms in Major Depression

2020 ◽  
Vol 10 (11) ◽  
pp. 792
Author(s):  
Djamila Bennabi ◽  
Nicolas Carvalho ◽  
Ambra Bisio ◽  
Juliana Teti Mayer ◽  
Thierry Pozzo ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Dorsolateral Prefrontal Cortex ◽  
Rating Scale ◽  
Small Sample ◽  
Psychomotor Activity ◽  
Direct Current Stimulation ◽  
Depressed Patients ◽  
Dorsolateral Prefrontal

Background: Transcranial direct current stimulation (tDCS) applied to the left dorsolateral prefrontal cortex (dlPFC) might be a promising treatment strategy for depression. As disturbances in psychomotor activity are one of the key features of unipolar depression are, we aimed to evaluate the behavioral effects of ten tDCS sessions over a 5-day period on psychomotor retardation in depressed patients. Methods: Twenty-three treatment-resistant depressed patients received either active or sham anodal tDCS to the left dorsolateral prefrontal cortex (2 mA, 10 sessions over 1 week). Psychomotor functioning was registered by means of observer ratings (Salpêtrière Retardation Rating Scale—SRRS) and objective measures (kinematical analysis of movements, automatic imitation). Results: tDCS sessions resulted in improvements on SRRS scores, although active tDCS was not significantly superior to sham tDCS on the kinematical parameters. Furthermore, no general additional antidepressant effect of tDCS was observed. The relatively small sample size and the short periods of observation should be considered when interpreting these results. Conclusion: tDCS did not induce a clinically relevant effect on psychomotor function in active and sham stimulation groups.

scholarly journals Verbal Fluency in Mild Alzheimer’s Disease: Transcranial Direct Current Stimulation over the Dorsolateral Prefrontal Cortex

2021 ◽  
pp. 1-11
Author(s):  
Daniela Smirni ◽  
Massimiliano Oliveri ◽  
Eliana Misuraca ◽  
Angela Catania ◽  
Laura Vernuccio ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Verbal Fluency ◽  
Dorsolateral Prefrontal Cortex ◽  
Control Group ◽  
Direct Current Stimulation ◽  
Cathodal Tdcs ◽  
Dorsolateral Prefrontal ◽  
The Right

Background: Recent studies showed that in healthy controls and in aphasic patients, inhibitory trains of repetitive transcranial magnetic stimulation (rTMS) over the right prefrontal cortex can improve phonemic fluency performance, while anodal transcranial direct current stimulation (tDCS) over the left prefrontal cortex can improve performance in naming and semantic fluency tasks. Objective: This study aimed at investigating the effects of cathodal tDCS over the left or the right dorsolateral prefrontal cortex (DLPFC) on verbal fluency tasks (VFT) in patients with mild Alzheimer’s disease (AD). Methods: Forty mild AD patients participated in the study (mean age 73.17±5.61 years). All participants underwent cognitive baseline tasks and a VFT twice. Twenty patients randomly received cathodal tDCS to the left or the right DLPFC, and twenty patients were assigned to a control group in which only the two measures of VFT were taken, without the administration of the tDCS. Results: A significant improvement of performance on the VFT in AD patients was present after tDCS over the right DLPFC (p = 0.001). Instead, no difference was detected between the two VFTs sessions after tDCS over the left DLPFC (p = 0.42). Furthermore, these results cannot be related to task learning effects, since no significant difference was found between the two VFT sessions in the control group (p = 0.73). Conclusion: These data suggest that tDCS over DLPFC can improve VFT performance in AD patients. A hypothesis is that tDCS enhances adaptive patterns of brain activity between functionally connected areas.

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