Metal-free hydroxylation of tertiary ketones under intensified and scalable continuous flow conditions

2020 ◽  
Vol 10 (1) ◽  
pp. 167-179 ◽  
Author(s):  
Victor-Emmanuel H. Kassin ◽  
Thomas Toupy ◽  
Guillaume Petit ◽  
Pauline Bianchi ◽  
Elena Salvadeo ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Conditions ◽  
Metal Free

scholarly journals Efficient metal-free photochemical borylation of aryl halides under batch and continuous-flow conditions

2016 ◽  
Vol 7 (6) ◽  
pp. 3676-3680 ◽  
Author(s):  
Kai Chen ◽  
Shuai Zhang ◽  
Pei He ◽  
Pengfei Li
Keyword(s):  
Continuous Flow ◽  
Aryl Halides ◽  
Flow Conditions ◽  
Metal Free ◽  
Bond Forming

A metal-free C–B bond forming reaction of aryl halides under batch and continuous-flow conditions is described.

A metal-free synthesis of 1,1-diphenylvinylsulfides with thiols via thioetherification under continuous-flow conditions

2020 ◽  
Vol 7 (12) ◽  
pp. 1490-1494 ◽  
Author(s):  
Jiawei Zhang ◽  
Erfei Wang ◽  
Yang Zhou ◽  
Lu Zhang ◽  
Mao Chen ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Chemistry ◽  
Flow Conditions ◽  
Aggregation Induced Emission ◽  
Metal Free ◽  
Mild Conditions ◽  
Continuous Flow Chemistry ◽  
Efficient Access

A continuous-flow chemistry facilitated protocol that allows efficient access to a novel aggregation-induced emission (AIE) luminogen 1,1-diphenylvinylsulfides utilizing thiols under metal-free and mild conditions.

scholarly journals Development of an efficient and sustainable synthesis of 2-(3-methyl-1H-1,2,4-triazol-1-yl) acetic acid under continuous-flow conditions

2020 ◽  
Vol 22 (12) ◽  
pp. 3748-3758 ◽  
Author(s):  
Simone Tortoioli ◽  
Astrid Friedli ◽  
Alice Prud'homme ◽  
Sylvia Richard-Bildstein ◽  
Philipp Kohler ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Continuous Flow ◽  
Triazole Ring ◽  
Flow Conditions ◽  
Metal Free ◽  
Free Process ◽  
Efficient Construction

A novel, metal-free process for the challenging synthesis of 1,2,4-triazoles is reported, which features an efficient construction of the triazole ring under flow conditions.

scholarly journals A Continuous-Flow, Two-Step, Metal-Free Process for the Synthesis of Differently Substituted Chiral 1,2-Diamino Derivatives

Synthesis ◽  
2018 ◽  
Vol 50 (07) ◽  
pp. 1430-1438
Author(s):  
Maurizio Benaglia ◽  
Margherita Pirola ◽  
Maria Compostella ◽  
Laura Raimondi ◽  
Alessandra Puglisi
Keyword(s):  
Continuous Flow ◽  
Catalytic Synthesis ◽  
Flow Conditions ◽  
Reaction Conditions ◽  
Flow Process ◽  
Preliminary Screening ◽  
Metal Free ◽  
Free Process ◽  
Continuous Flow Process ◽  
Nitro Reduction

The enantioselective organocatalytic reduction of aryl-substituted nitroenamines was successfully performed under continuous-flow conditions. After a preliminary screening with a 10-μL microreactor, to establish the best reaction conditions, the reduction was scaled up in a 0.5-mL mesoreactor, without appreciable loss of enantioselectivity, that remained constantly higher than 90%. The in-flow nitro reduction was also accomplished, either by Raney nickel catalyzed hydrogenation or by a metal-free methodology based on the use of the very inexpensive and readily available reducing agent trichlorosilane. The final aim is to develop a two-step, continuous-flow process for the stereo­selective, metal-free, catalytic synthesis of differently functionalized chiral 1,2-diamines.

scholarly journals Development of an Efficient and Sustainable Synthesis of 2-(3-Methyl-1H-1,2,4-Triazol-1-Yl) Acetic Acid Under Continuous-Flow Conditions

2020 ◽  
Author(s):  
Simone Tortoioli ◽  
Astrid Friedli ◽  
Alice Prud’homme ◽  
Sylvia Richard-Bildstein ◽  
Philipp Kohler ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Continuous Flow ◽  
Flow Reactor ◽  
Environmentally Benign ◽  
Sustainable Construction ◽  
Flow Conditions ◽  
Step Method ◽  
Metal Free ◽  
Free Process ◽  
Synthetic Routes

A novel, metal-free process for the challenging synthesis of 2-(3-methyl-1<i>H</i>-1,2,4-triazol-1-yl) acetic acid (<b>1</b>) is reported, which features an efficient condensation for the triazole build-up under flow conditions. This continuous, two-step method is atom economical, highly selective and environmentally benign, due to the avoidance of chromatography and isolation steps. Compared to the earlier batch synthetic routes, higher yields were achieved in a flow reactor. In addition, a highly energetic intermediate could be controlled and handled in a safe manner. To generalize the established route, several triazoles were finally prepared under the described conditions, confirming that the methodology could find useful applications for the rapid and sustainable construction of differentially functionalized 1,2,4-triazoles.

scholarly journals Continuous-flow synthesis of primary amines: Metal-free reduction of aliphatic and aromatic nitro derivatives with trichlorosilane

2016 ◽  
Vol 12 ◽  
pp. 2614-2619 ◽  
Author(s):  
Riccardo Porta ◽  
Alessandra Puglisi ◽  
Giacomo Colombo ◽  
Sergio Rossi ◽  
Maurizio Benaglia
Keyword(s):  
Continuous Flow ◽  
Reaction Times ◽  
Nitro Compounds ◽  
Primary Amines ◽  
Flow Conditions ◽  
Metal Free ◽  
Nitro Derivatives ◽  
Aromatic Nitro ◽  
High Yields ◽  
First Time

The metal-free reduction of nitro compounds to amines mediated by trichlorosilane was successfully performed for the first time under continuous-flow conditions. Aromatic as well as aliphatic nitro derivatives were converted to the corresponding primary amines in high yields and very short reaction times with no need for purification. The methodology was also extended to the synthesis of two synthetically relevant intermediates (precursors of baclofen and boscalid).

scholarly journals Development of an Efficient and Sustainable Synthesis of 2-(3-Methyl-1H-1,2,4-Triazol-1-Yl) Acetic Acid Under Continuous-Flow Conditions

2020 ◽  
Author(s):  
Simone Tortoioli ◽  
Astrid Friedli ◽  
Alice Prud’homme ◽  
Sylvia Richard-Bildstein ◽  
Philipp Kohler ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Continuous Flow ◽  
Flow Reactor ◽  
Environmentally Benign ◽  
Sustainable Construction ◽  
Flow Conditions ◽  
Step Method ◽  
Metal Free ◽  
Free Process ◽  
Synthetic Routes

A novel, metal-free process for the challenging synthesis of 2-(3-methyl-1<i>H</i>-1,2,4-triazol-1-yl) acetic acid (<b>1</b>) is reported, which features an efficient condensation for the triazole build-up under flow conditions. This continuous, two-step method is atom economical, highly selective and environmentally benign, due to the avoidance of chromatography and isolation steps. Compared to the earlier batch synthetic routes, higher yields were achieved in a flow reactor. In addition, a highly energetic intermediate could be controlled and handled in a safe manner. To generalize the established route, several triazoles were finally prepared under the described conditions, confirming that the methodology could find useful applications for the rapid and sustainable construction of differentially functionalized 1,2,4-triazoles.

Metal–organic frameworks for the removal of the emerging contaminant atenolol under real conditions

2021 ◽  
Vol 50 (7) ◽  
pp. 2493-2500
Author(s):  
Sara Rojas ◽  
Jorge A. R. Navarro ◽  
Patricia Horcajada
Keyword(s):  
Continuous Flow ◽  
Metal Organic Frameworks ◽  
Fixed Bed ◽  
Emerging Contaminant ◽  
Flow Conditions ◽  
Metal Organic ◽  
Fixed Bed System

A defective Metal-Organic Frameworks as an improved material for the construction of a fixed-bed system working under continuous flow conditions for the removal of the emerging contaminant atenolol.

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