The role of pioneer neurons in the development of mouse visual cortex and corpus callosum

2001 ◽  
Vol 204 (6) ◽  
pp. 437-453 ◽  
Author(s):  
Jinbo Deng ◽  
A. J. Elberger
Keyword(s):  
Visual Cortex ◽  
Corpus Callosum ◽  
Pioneer Neurons ◽  
Mouse Visual Cortex

scholarly journals On Synchronizing Coupled Retinogeniculocortical Pathways: A Toy Model

2018 ◽  
Vol 2018 ◽  
pp. 1-6
Author(s):  
B. L. Mayer ◽  
L. H. A. Monteiro
Keyword(s):  
Neural Network ◽  
Visual Cortex ◽  
Corpus Callosum ◽  
Neuronal Activity ◽  
Network Topology ◽  
Cerebral Hemisphere ◽  
State Transition ◽  
Regular Lattice ◽  
Visual Cortices

A Newman-Watts graph is formed by including random links in a regular lattice. Here, the emergence of synchronization in coupled Newman-Watts graphs is studied. The whole neural network is considered as a toy model of mammalian visual pathways. It is composed by four coupled graphs, in which a coupled pair represents the lateral geniculate nucleus and the visual cortex of a cerebral hemisphere. The hemispheres communicate with each other through a coupling between the graphs representing the visual cortices. This coupling makes the role of the corpus callosum. The state transition of neurons, supposed to be the nodes of the graphs, occurs in discrete time and it follows a set of deterministic rules. From periodic stimuli coming from the retina, the neuronal activity of the whole network is numerically computed. The goal is to find out how the values of the parameters related to the network topology affect the synchronization among the four graphs.

scholarly journals Laminar-specific cortico-cortical loops in mouse visual cortex

2019 ◽  
Author(s):  
Hedi Young ◽  
Beatriz Belbut ◽  
Margarida Baeta ◽  
Leopoldo Petreanu
Keyword(s):  
Visual Cortex ◽  
Cortical Circuits ◽  
Cortical Input ◽  
Cortical Connections ◽  
Cortical Hierarchy ◽  
Input Source ◽  
Innervation Patterns ◽  
Mouse Visual Cortex ◽  
Apical Dendrites

AbstractMany theories propose recurrent interactions across the cortical hierarchy, but it is unclear if cortical circuits are selectively wired to implement looped computations. Using subcellular channelrhodopsin-2-assisted circuit mapping in mouse visual cortex, we compared feedforward (FF) or feedback (FB) cortico-cortical input to cells projecting back to the input source (looped neurons) with cells projecting to a different cortical or subcortical area (non-looped neurons). Despite having different laminar innervation patterns, FF and FB afferents showed similar cell-type selectivity, making stronger connections with looped neurons versus non-looped neurons in layer (L) 5 and L6, but not in L2/3. FB inputs preferentially innervated the apical tufts of looped L5 neurons, but not their perisomatic dendrites. Our results reveal that interareal cortical connections are selectively wired into monosynaptic excitatory loops involving L6 and the apical dendrites of L5 neurons, supporting a role of these circuit elements in hierarchical recurrent computations.

scholarly journals Laminar-specific cortico-cortical loops in mouse visual cortex

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Hedi Young ◽  
Beatriz Belbut ◽  
Margarida Baeta ◽  
Leopoldo Petreanu
Keyword(s):  
Visual Cortex ◽  
Synaptic Input ◽  
Cortical Circuits ◽  
Cell Type ◽  
Cortical Hierarchy ◽  
Selective Modulation ◽  
Input Source ◽  
Similar Cell ◽  
Mouse Visual Cortex

Many theories propose recurrent interactions across the cortical hierarchy, but it is unclear if cortical circuits are selectively wired to implement looped computations. Using subcellular channelrhodopsin-2-assisted circuit mapping in mouse visual cortex, we compared feedforward (FF) or feedback (FB) cortico-cortical (CC) synaptic input to cells projecting back to the input source (looped neurons) with cells projecting to a different cortical or subcortical area. FF and FB afferents showed similar cell-type selectivity, making stronger connections with looped neurons than with other projection types in layer (L)5 and L6, but not in L2/3, resulting in selective modulation of activity in looped neurons. In most cases, stronger connections in looped L5 neurons were located on their apical tufts, but not on their perisomatic dendrites. Our results reveal that CC connections are selectively wired to form monosynaptic excitatory loops and support a differential role of supragranular and infragranular neurons in hierarchical recurrent computations.

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