Chronic hyperglycemia impairs mitochondrial unfolded protein response and precipitates proteotoxicity in experimental diabetic neuropathy: focus on LonP1 mediated mitochondrial regulation

2020 ◽  
Vol 72 (6) ◽  
pp. 1627-1644
Author(s):  
Anil Kumar Kalvala ◽  
Veera Ganesh Yerra ◽  
Bhoomika Sherkhane ◽  
Chayanika Gundu ◽  
Vijay Arruri ◽  
...  
Keyword(s):  
Diabetic Neuropathy ◽  
Unfolded Protein Response ◽  
Unfolded Protein ◽  
Mitochondrial Regulation ◽  
Chronic Hyperglycemia ◽  
Protein Response ◽  
Experimental Diabetic Neuropathy ◽  
Mitochondrial Unfolded Protein Response

scholarly journals At the heart of mitochondrial quality control: many roads to the top

2021 ◽  
Author(s):  
Roberta A. Gottlieb ◽  
Honit Piplani ◽  
Jon Sin ◽  
Savannah Sawaged ◽  
Syed M. Hamid ◽  
...  
Keyword(s):  
Quality Control ◽  
Unfolded Protein Response ◽  
Mitochondrial Biogenesis ◽  
Mitochondrial Dynamics ◽  
Mitochondrial Quality Control ◽  
Unfolded Protein ◽  
Selective Elimination ◽  
Protein Response ◽  
Mitochondrial Unfolded Protein Response

AbstractMitochondrial quality control depends upon selective elimination of damaged mitochondria, replacement by mitochondrial biogenesis, redistribution of mitochondrial components across the network by fusion, and segregation of damaged mitochondria by fission prior to mitophagy. In this review, we focus on mitochondrial dynamics (fusion/fission), mitophagy, and other mechanisms supporting mitochondrial quality control including maintenance of mtDNA and the mitochondrial unfolded protein response, particularly in the context of the heart.

scholarly journals The Mitochondrial Unfolded Protein Response Is Mediated Cell-Non-autonomously by Retromer-Dependent Wnt Signaling

Cell ◽  
2018 ◽  
Vol 174 (4) ◽  
pp. 870-883.e17 ◽  
Author(s):  
Qian Zhang ◽  
Xueying Wu ◽  
Peng Chen ◽  
Limeng Liu ◽  
Nan Xin ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Unfolded Protein Response ◽  
Unfolded Protein ◽  
Protein Response ◽  
Mitochondrial Unfolded Protein Response
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