Evaluation of Clinical Trials in Onco-haematology: A New Method Based on Risk Analysis and Multidisciplinarity

2021 ◽  
Author(s):  
J. Lapière ◽  
C. Christen ◽  
G. Kerouani-Lafaye ◽  
A. Monard ◽  
F. Turcry ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Risk Analysis ◽  
New Method

scholarly journals Occlusion of left atrial appendage in patients with atrial fibrillation

2015 ◽  
Vol 18 (4) ◽  
pp. 104 ◽  
Author(s):  
O. N. Ganeeva
Keyword(s):  
Atrial Fibrillation ◽  
Clinical Trials ◽  
Left Atrial ◽  
Left Atrial Appendage ◽  
Atrial Appendage ◽  
New Method ◽  
Step Process

The article reviews a new method of prophylaxis of thromboembolitic complications, specifically occlusion of left atrial appendage, in patients with atrial fibrillation. Indications and contraindications for the procedure, as well as a step-by-step process of the intervention itself are described. Special emphasis is placed on the up-to-date evidence and the review of clinical trials.

The Cost–Time Index: A new method for measuring the efficiencies of recruitment-resources in clinical trials

2006 ◽  
Vol 27 (6) ◽  
pp. 494-497 ◽  
Author(s):  
Ken S. Ota ◽  
Leah Friedman ◽  
J. Wesson Ashford ◽  
Beatriz Hernandez ◽  
Allison L. Penner ◽  
...  
Keyword(s):  
Clinical Trials ◽  
New Method ◽  
Time Index ◽  
The Cost

Trials and Tribulations

1959 ◽  
Vol 105 (441) ◽  
pp. 1082-1087 ◽  
Author(s):  
A. A. Baker ◽  
J. G. Thorpe
Keyword(s):  
Clinical Trial ◽  
Clinical Trials ◽  
Positive Result ◽  
New Method ◽  
Medical Statistics ◽  
Control Groups ◽  
Therapeutic Success ◽  
Sixth Edition ◽  
Bradford Hill ◽  
Physical Therapies

With the advent of effective physical therapies, psychiatrists have become increasingly interested in the problems posed by clinical trials. Professor Bradford Hill, in the Preface to the Sixth Edition of his Principles of Medical Statistics (1) noted that “… passage of time has … brought clinical trials into prominence and fashion …”. More recently Professor Pickering has described the clinical trial as “the most important new method introduced into clinical science in recent years” (2). Some interesting differences between controlled and uncontrolled trials are well brought out in the paper by Foulds (3) in which he found that therapeutic success was claimed in 85 per cent. of studies not using control groups. Among those studies using control groups, however, only 25 per cent. obtained a positive result. He concluded that “claims for the success of a treatment are closely associated with absence of the means whereby these claims can be scientifically substantiated”.

scholarly journals Evaluating the Efficiency of School Preceptors by Fuzzy Risk Analysis

2013 ◽  
Vol 2013 ◽  
pp. 1-14 ◽  
Author(s):  
Rasoul Saneifard ◽  
Rahim Saneifard
Keyword(s):  
Risk Analysis ◽  
Fuzzy Number ◽  
Fuzzy Numbers ◽  
New Method ◽  
Arithmetic Operations ◽  
Fuzzy Risk Analysis ◽  
Fuzzy Weights

This paper presents a new method for evaluating the efficiency of school preceptors based on fuzzy number arithmetic operations. It uses fuzzy numbers to represent fuzzy grades. The fuzzy weights of criteria are automatically generated from the opinions of evaluators. The simplified fuzzy number arithmetic operations are used for calculating the average of fuzzy numbers. It can evaluate the efficiency of school preceptors in a more flexible and more intelligent manner.

A new method for risk analysis of vaccines

Vaccine ◽  
1999 ◽  
Vol 17 (19) ◽  
pp. 2335 ◽  
Author(s):  
J Poirriez
Keyword(s):  
Risk Analysis ◽  
New Method

scholarly journals Comparative efficacy of different acute reperfusion therapies for acute ischemic stroke: a comprehensive benefit-risk analysis of clinical trials

2014 ◽  
Vol 4 (6) ◽  
pp. 789-797 ◽  
Author(s):  
Georgios Tsivgoulis ◽  
John Alleman ◽  
Aristeidis H. Katsanos ◽  
Andrew D. Barreto ◽  
Martin Kohrmann ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Ischemic Stroke ◽  
Risk Analysis ◽  
Acute Ischemic Stroke ◽  
Comparative Efficacy ◽  
Comprehensive Benefit

scholarly journals The Global Risk Analysis as a tool to secure drug management of clinical trials in hospitals

2018 ◽  
Vol WCP2018 (0) ◽  
pp. PO3-12-16
Author(s):  
Jacques A Weissenburger ◽  
Juliette Godard ◽  
Caroline Ly ◽  
Anne Daguenel ◽  
Christine Fernandez ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Risk Analysis ◽  
Global Risk ◽  
Drug Management

scholarly journals A practical synthesis of deuterated methylamine and dimethylamine

2020 ◽  
pp. 174751982096963
Author(s):  
Zhaogang Liu ◽  
Xiangyu Ren ◽  
Peng Wang
Keyword(s):  
Clinical Trials ◽  
Starting Material ◽  
New Method ◽  
The Future ◽  
Practical Synthesis ◽  
High Yields

In recent years, several deuterated drugs have entered clinical trials and have been approved for use. Deuterated methylamine and dimethylamine as important intermediates play significant roles in the preparation of deuterated drugs. In this study, we have developed a new method to prepare deuterated methylamine and dimethylamine. This method employs Boc-benzylamine as the starting material and TsOCD3 as the deuterated methylation reagent. Our method gives relatively high yields and involves simple purifications, which provide a favourable supplement for the development and synthesis of deuterated drugs in the future.

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