scholarly journals Investigation of Hemodynamic Receptors of the Internal Carotid Artery Segments

2021 ◽  
Author(s):  
Mehmet Deniz Yener ◽  
Tuncay Colak ◽  
Belgin Bamac ◽  
Ahmet Ozturk ◽  
Selenay Humeyra Rencber ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Internal Carotid Artery ◽  
Outer Surface ◽  
Laser Scanning ◽  
Internal Carotid ◽  
Venous Blood ◽  
Cervical Region ◽  
Tunica Media ◽  
Arterial Blood ◽  
The Brain

Abstract Objectives Internal carotid artery (ICA), the main artery of the brain, passes through the cavernous sinus (CS) which forms one of these venous pools. During this transition, while there is arterial blood in the lumen of ICA, its outer surface is in contact with venous blood from the brain. Herein, we aimed to detect the receptor differences of ICA in this highly specialized anatomical region of the skull base. Methods We performed the study on 10 human cadavers and searched CGRPR, TRP12, ASIC3 and ACTHR receptors via immunostaining using laser scanning confocal microscopy. Results We determined TRP12 receptor positive in the tunica media and tunica adventitia layers of the cavernous segment of ICA. We did not detect similar positivity in the cervical part of the ICA. In the receptor scan we made in terms of CGRPR, while we detected positivity in the tunica media layer of the cavernous segment, we found positivity in the tunica intima layer of the cervicalis segment of the ICA. We did not detect any positivity for ASIC3 and ACTHR receptors in both parts of the ICA. Conclusions As a result, we observed various differences in receptors between ICA segments. While the outer surface of the ICA in the cervical region did not show any receptor positivity, we detected TRP12 receptor positivity along the tissue contour of vessel in the CS. We assume that it may provide a new perspective on pathologies of the CS/ICA and preservation of brain hemodynamics for clinicians.

Blood-brain barrier transport of neuropeptides: analysis with a metabolically stable dermorphin analogue

1994 ◽  
Vol 267 (1) ◽  
pp. E124-E131 ◽  
Author(s):  
A. Samii ◽  
U. Bickel ◽  
U. Stroth ◽  
W. M. Pardridge
Keyword(s):  
Carotid Artery ◽  
Internal Carotid Artery ◽  
Intravenous Injection ◽  
Internal Carotid ◽  
Lipid Solubility ◽  
Permeability Surface ◽  
Bbb Permeability ◽  
The Brain ◽  
Artery Perfusion ◽  
Internal Carotid Artery Perfusion

To avoid the confounding effect of metabolic degradation, the stable mu-opioid peptide agonist [D-Arg2,Lys4]-dermorphin analogue (DALDA) was used to quantitate blood-brain barrier (BBB) permeability by intravenous injection and internal carotid artery perfusion techniques. With intravenous injection, the BBB permeability-surface area products for [3H]DALDA (0.84 +/- 0.13 microliters.min-1.g-1) and [14C]sucrose (0.39 +/- 0.05 microliters.min-1.g-1) correlated with the lipid solubility of the two molecules: the 1-octanol-Ringer partition coefficient for DALDA was approximately 2 log orders greater than that for sucrose. The brain delivery of [3H]DALDA at 30 min after intravenous administration was 0.019 +/- 0.002% of the injected dose per gram, and analgesia was induced with a 5-mg/kg dose administered systemically. In contrast to the result after intravenous injection, the BBB permeability-surface area product for DALDA estimated with the internal carotid artery perfusion technique was manyfold greater. This was due to nonspecific absorption of the peptide into the cerebral microvasculature, which precluded use of the capillary depletion technique to study transcytosis through the BBB after internal carotid artery perfusion. The present studies show that the brain delivery of a metabolically stable peptide, such as DALDA, is comparable to that for sucrose, correlates with lipid solubility, and is mediated by a nonsaturable mechanism, probably free diffusion.

scholarly journals The arteries of the brain base in the degu (Octodon degus Molina 1782)

2014 ◽  
Vol 59 (No. 7) ◽  
pp. 343-348 ◽  
Author(s):  
W. Brudnicki ◽  
B. Skoczylas ◽  
R. Jablonski ◽  
W. Nowicki ◽  
A. Brudnicki ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Internal Carotid Artery ◽  
Basilar Artery ◽  
Internal Carotid ◽  
Cerebral Arteries ◽  
Left Vertebral Artery ◽  
Brain Arteries ◽  
Middle Cerebral Arteries ◽  
The Brain ◽  
Synthetic Latex

The brain arteries derived from 50 adult degu individuals of both sexes were injected with synthetic latex introduced with a syringe into the left ventricle of the heart under constant pressure. After fixation in 5% formalin and brain preparation, it was found that the sources of the brain’s supply of blood are vertebral arteries and the basilar artery formed as a result of their anastomosis. The basilar artery gave rise to caudal cerebellar arteries and then divided into two branches which formed the arterial circle of the brain. The internal carotid arteries in degus, except for one case, were heavily reduced and did not play an important role in the blood supply to the brain. The arterial circle of the brain in 48% of the cases was open from the rostral side. Variation was identified in the anatomy and the pattern of the arteries of the base of the brain in the degu which involved an asymmetry of the descent of caudal cerebellar arteries (6.0%), rostral cerebellar arteries (8%) as well as middle cerebral arteries (12%). In 6% of the individuals double middle cerebral arteries were found. In one out of 50 cases there was observed a reduction in the left vertebral artery and the appearance of the internal carotid artery on the same side. In that case the left part of the arterial circle of the brain was supplied with blood by an internal carotid artery, which was present only in that animal.

Probabilistic map of blood flow distribution in the brain from the internal carotid artery

NeuroImage ◽  
2004 ◽  
Vol 23 (4) ◽  
pp. 1422-1431 ◽  
Author(s):  
Jae Sung Lee ◽  
Dong Soo Lee ◽  
Yu Kyeong Kim ◽  
Jinsu Kim ◽  
Ho Young Lee ◽  
...  
Keyword(s):  
Blood Flow ◽  
Carotid Artery ◽  
Internal Carotid Artery ◽  
Internal Carotid ◽  
Flow Distribution ◽  
Blood Flow Distribution ◽  
The Brain ◽  
Probabilistic Map

scholarly journals Superselective Intracerebral Catheterization of a Branch of the Internal Carotid Artery Coupled with Magnetic Resonance Imaging

2007 ◽  
Vol 13 (3) ◽  
pp. 277-280 ◽  
Author(s):  
J. Pryor ◽  
H. D'Arceuil ◽  
M. Phil ◽  
J. Liu ◽  
J. He ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Carotid Artery ◽  
Internal Carotid Artery ◽  
Brain Region ◽  
Internal Carotid ◽  
Fluoroscopic Guidance ◽  
Resonance Imaging ◽  
Assessment And Treatment ◽  
The Brain

We used fluoroscopic guidance and over-the-wire techniques to superselectively place a microcatheter into a branch of the MCA of three macaques and MRI bolus tracking techniques to measure perfusion within the selected brain region. Such techniques are likely to be useful in the assessment and treatment of ischemic infarction, cerebral vasospasm, and monitoring local delivery of drugs into the brain.

Otorrhagia from the “Aberrant Internal Carotid” Artery in the Middle Ear

1997 ◽  
Vol 3 (3) ◽  
pp. 231-238 ◽  
Author(s):  
M. Söderman ◽  
M. Moersdorf ◽  
M. Lysdahl ◽  
L. Mendel
Keyword(s):  
Carotid Artery ◽  
Internal Carotid Artery ◽  
Middle Ear ◽  
Internal Carotid ◽  
Large Artery ◽  
Arterial Aneurysm ◽  
Anatomical Variant ◽  
Cervical Portion ◽  
Aberrant Internal Carotid Artery ◽  
The Brain

Agenesis of the cervical portion of the internal carotid artery (ICA) may result in blood supply to the ipsilateral cerebral hemisphere being provided by an enlarged inferior tympanic branch of the ascending pharyngeal artery. This enlarged vessel, passing through Jacobson's canal and anastomosing with the likewise enlarged caroticotympanic branch of the ICA in front of the promontorium, may simulate a middle ear mass. We present five patients with this unusual anatomical variant, three of which underwent biopsy of what was believed to be a middle ear tumour. One patient experienced rupture of an arterial aneurysm in the middle ear successfully treated with endovascular application of detachable platinum coils. It is mandatory for ENT-surgeons and radiologists who perform head-and-neck examinations to recognize this anatomical variant, not mistaking it for a tumour, since biopsy of a large artery supplying the brain may have disastrous consequences. In patients with otorrhagia, an arterial aneurysm must be considered as a possible source of bleeding, in some cases amenable for treatment with an endovascular technique. The diagnosis of “aberrant internal carotid artery” is usually made with CT of the temporal bone or MR of the skull base. Cerebral angiography is in most cases not necessary, unless an endovascular procedure is planned.

scholarly journals 16. Hemangiomatous Malformation of bilateral Internal Carotid Artery at the Base of the Brain

1964 ◽  
Vol 6 (0) ◽  
pp. 60-61 ◽  
Author(s):  
Akira NISHIMOTO ◽  
Ryosuke SUGIU ◽  
Tetsuya MANNAMI
Keyword(s):  
Carotid Artery ◽  
Internal Carotid Artery ◽  
Internal Carotid ◽  
The Brain

scholarly journals Study of the blood supply of the brain in sheep

1999 ◽  
Vol 23 (1) ◽  
pp. 59-66
Author(s):  
Khalid Kamil Kadhum
Keyword(s):  
Carotid Artery ◽  
Internal Carotid Artery ◽  
Blood Supply ◽  
Basilar Artery ◽  
Internal Carotid ◽  
Ventral Surface ◽  
Circle Of Willis ◽  
Maxillary Artery ◽  
Cerebellar Artery ◽  
The Brain

The brain of the sheep receives its blood supply through the carotid rete and the basilar artery. The carotid rete formed of contribution of internal carotid artery and branches from maxillary artery. The internal carotid artery courses on the ventral surface of the cerebal crus to give the rostral cerebal artery and the caudal communicating artery . Thus , arteries excepted the middle cerebal artery forming with the same arteries of the opposite side , the cerebal arterial circle or circle of Willis. The internal caroted artery also gives off hypophysialartery to the  1999 ind, (1) swell, ügymielly wel dati', il pellilendiambell ileti  hypophysis. The caudal communicating artery give off the caudal cerebal artery and the rostral cerebellar artery and unite with the corresponding artery of the opposite side to form the basilar artery rostral to the pone . The basilar artery gives off the pontine artery , caudal cerebellar artery and the medullary branch. 

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