Immunologic and biochemical studies in infants and children with special reference to rheumatic fever. VI. Electrophoretic patterns of blood plasma and serum in rheumatic children

1949 ◽  
Vol 38 (6) ◽  
pp. 931
Author(s):  
Johnson
Keyword(s):  
Rheumatic Fever ◽  
Blood Plasma ◽  
Special Reference ◽  
Infants And Children ◽  
Electrophoretic Patterns ◽  
Biochemical Studies ◽  
In Infants And Children

IMMUNOLOGIC AND BIOCHEMICAL STUDIES IN INFANTS AND CHILDREN WITH SPECIAL REFERENCE TO RHEUMATIC FEVER

PEDIATRICS ◽  
1948 ◽  
Vol 2 (5) ◽  
pp. 577-583
Author(s):  
MAY G. WILSON ◽  
ROSE LUBSCHEZ
Keyword(s):  
Immune Response ◽  
Rheumatic Fever ◽  
Blood Plasma ◽  
Special Reference ◽  
Acute Rheumatic Fever ◽  
Gamma Globulin ◽  
Respiratory Illness ◽  
Infants And Children ◽  
Biochemical Studies ◽  
In Infants And Children

Electrophoretic analyses are presented for 79 specimens of blood plasma or serum from 42 rheumatic subjects during apparent health, following respiratory illness, and during rheumatic fever. Electrophoretic studies revealed a prolonged elevation in the gamma component for a period varying from weeks to months following an antecedent respiratory illness with or without the development of rheumatic fever. During acute rheumatic fever, the gamma globulin component was normal in the absence of antecedent illness. Elevation of the gamma globulin component in rheumatic fever is not a function of the rheumatic process. The alpha globulin components were usually elevated during febrile periods. No evidence was obtained in these studies that the immune response of rheumatic subjects to infections presumably streptococcal in origin differed from that of nonrheumatic individuals.

IMMUNOLOGIC AND BIOCHEMICAL STUDIES IN INFANTS AND CHILDREN, WITH SPECIAL REFERENCE TO RHEUMATIC FEVER

PEDIATRICS ◽  
1948 ◽  
Vol 2 (4) ◽  
pp. 410-414
Author(s):  
PAUL F. DEGARA
Keyword(s):  
Rheumatic Fever ◽  
Special Reference ◽  
High Titer ◽  
Infants And Children ◽  
Significant Difference ◽  
Biochemical Studies ◽  
History Of ◽  
Group A ◽  
Different Strains ◽  
In Infants And Children

Agglutinative antibodies for three different strains Str. hemolyticus, beta, group A, were studied in 497 sera from 372 children. A high titer was found in approximately 9% of well children. There was no significant difference between rheumatic and non-rheumatic subjects in the incidence of high agglutinin titers for Str. hemolyticus. Following infections, presumably streptococcal in origin, approximately 46% of the children examined had high agglutinin titers for Str. hemolyticus. In active rheumatic fever, agglutinins were present in high titers in nine out of 11 patients who had experienced an antecedent illness, presumably streptococcal in origin. Of 23 patients with no history of such an infection, only three had streptococcal agglutinins.

IMMUNOLOGIC AND BIOCHEMICAL STUDIES IN INFANTS AND CHILDREN WITH SPECIAL REFERENCE TO RHEUMATIC FEVER

PEDIATRICS ◽  
1948 ◽  
Vol 2 (3) ◽  
pp. 248-254
Author(s):  
PAUL F. DEGARA ◽  
HENRY P. GOLDBERG
Keyword(s):  
Rheumatic Fever ◽  
Special Reference ◽  
Infants And Children ◽  
Normal Children ◽  
Complement Activity ◽  
Intercurrent Illness ◽  
Biochemical Studies ◽  
Hereditary Susceptibility ◽  
In Infants And Children

Complement activity of 421 sera from 330 children was determined. Complement activity was not influenced by antecedent illness. Low complement titers were found in approximately 25% of 75 normal children during intercurrent illness. Approximately 25% of 29 patients with active rheumatic fever had low complement titers. No evidence was obtained to indicate that complement activity is a factor in hereditary susceptibility to rheumatic fever.

IMMUNOLOGIC AND BIOCHEMICAL STUDIES IN INFANTS AND CHILDREN WITH SPECIAL REFERENCE TO RHEUMATIC FEVER

PEDIATRICS ◽  
1948 ◽  
Vol 2 (3) ◽  
pp. 242-247
Author(s):  
PAUL F. DEGARA ◽  
HENRY P. GOLDBERG
Keyword(s):  
Rheumatic Fever ◽  
Special Reference ◽  
Infants And Children ◽  
Entire Group ◽  
Healthy Children ◽  
Complement Activity ◽  
Biochemical Studies ◽  
The Mean ◽  
In Infants And Children

Complement titers of 128 sera from 107 healthy children ranging in age from three days to 15 years are presented. The 50% hemolysis method was used. In 107 instances (83.5%), the complement titer ranged between 0.0040 Ml. and 0.0069 Ml., while eight sera (6.3%) had higher titers, and in 13 instances (10.2%), the complement activity was low. The mean titer for the entire group was 0.0053 ± 0.00115 Ml. Repeated determinations on the same individuals showed that complement activity usually remained constant over prolonged periods. Complement activity did not vary with age, sex or season of the year in which the specimens were obtained.

IMMUNOLOGIC AND BIOCHEMICAL STUDIES IN INFANTS AND CHILDREN WITH SPECIAL REFERENCE TO RHEUMATIC FEVER

PEDIATRICS ◽  
1948 ◽  
Vol 2 (5) ◽  
pp. 570-576
Author(s):  
ROSE LUBSCHEZ
Keyword(s):  
Rheumatic Fever ◽  
Genetic Basis ◽  
Gamma Globulin ◽  
Relative Concentration ◽  
Electrophoretic Pattern ◽  
Normal Children ◽  
Beta Globulin ◽  
Biochemical Studies ◽  
The Individual ◽  
In Infants And Children

Electrophoretic analyses of blood plasma or serum of 30 children in apparent health between the ages of two and 11 years revealed that the relative concentration of the various components was in close agreement with adult values, although the individual variation was several times greater. For 27 children in apparent health, but who had experienced various types of infection during a one to four month interval prior to the time the specimen was taken, elevation of the gamma component occurred in about 40% of the determinations. Illness within the month produced the greatest number of abnormalities, although abnormalities were noted in specimens of children who had been free of infection two to three months. A few abnormalities were noted in all components except beta globulin. At younger ages (two to four years) children showed a slightly higher albumen level and a slightly lower gamma globulin level. Normal children susceptible to rheumatic fever on a genetic basis exhibited no specific differences in the electrophoretic pattern.

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