Drug-induced torsades de pointes: Role of early afterdepolarizations and dispersion of repolarization

1990 ◽  
Vol 89 (2) ◽  
pp. 241-246 ◽  
Author(s):  
Moh'd A. Habbab ◽  
Nabil El-Sherie
Keyword(s):  
Torsades De Pointes ◽  
Drug Induced ◽  
Early Afterdepolarizations ◽  
Dispersion Of Repolarization

Drug-induced torsades de pointes: The evolving role of pharmacogenetics

Heart Rhythm ◽  
2005 ◽  
Vol 2 (11) ◽  
pp. S30-S37 ◽  
Author(s):  
Patrick T. Fitzgerald ◽  
Michael J. Ackerman
Keyword(s):  
Torsades De Pointes ◽  
Drug Induced

scholarly journals Utility of hERG Assays as Surrogate Markers of Delayed Cardiac Repolarization and QT Safety

2006 ◽  
Vol 34 (1) ◽  
pp. 81-90 ◽  
Author(s):  
Gary A. Gintant ◽  
Zhi Su ◽  
Ruth L. Martin ◽  
Bryan F. Cox
Keyword(s):  
Cardiac Electrophysiology ◽  
Critical Role ◽  
Drug Effects ◽  
Torsades De Pointes ◽  
Cardiac Repolarization ◽  
Surrogate Markers ◽  
Related Gene ◽  
Drug Induced ◽  
Herg Current

HERG (human-ether-a-go-go-related gene) encodes for a cardiac potassium channel that plays a critical role in defining ventricular repolarization. Noncardiovascular drugs associated with a rare but potentially lethal ventricular arrhythmia (Torsades de Pointes) have been linked to delayed cardiac repolarization and block of hERG current. This brief overview will discuss the role of hERG current in cardiac electrophysiology, its involvement in drug-induced delayed repolarization, and approaches used to define drug effects on hERG current. In addition, examples of hERG blocking drugs acting differently (i.e., overt and covert hERG blockade due to multichannel block) together with the utility and limitations of hERG assays as tools to predict the risk of delayed repolarization and proarrhythmia are discussed.

The possible role of propofol in drug-induced torsades de pointes: A real-world single-center analysis

2017 ◽  
Vol 232 ◽  
pp. 243-246 ◽  
Author(s):  
Victor A. Abrich ◽  
Harish Ramakrishna ◽  
Arjun Mehta ◽  
Farouk Mookadam ◽  
Komandoor Srivathsan
Keyword(s):  
Real World ◽  
Torsades De Pointes ◽  
Single Center ◽  
Drug Induced
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