The natural history of asymptomatic bacteriuria during pregnancy: The effect of tetracycline on the clinical course and the outcome of pregnancy

1971 ◽  
Vol 111 (3) ◽  
pp. 441-462 ◽  
Author(s):  
H.A. Elder ◽  
B.A.G. Santamarina ◽  
S. Smith ◽  
E.H. Kass
Keyword(s):  
Natural History ◽  
Clinical Course ◽  
Asymptomatic Bacteriuria ◽  
History Of

Adenoid Cystic Carcinoma of Lacrimal Gland

JMS SKIMS ◽  
2012 ◽  
Vol 15 (1) ◽  
pp. 76-77
Author(s):  
Mohd Athar ◽  
K S Sodhi ◽  
S Kala ◽  
R K Maurya ◽  
S Chauhan ◽  
...  
Keyword(s):  
Local Recurrence ◽  
Natural History ◽  
Adenoid Cystic Carcinoma ◽  
Salivary Glands ◽  
Hard Palate ◽  
Clinical Course ◽  
Fatal Outcome ◽  
Minor Salivary Glands ◽  
Adenoid Cystic ◽  
History Of

Adenoid cystic carcinoma is a relatively uncommon tumour of salivary, glands and is characterised by a prolonged clinical course and a fatal outcome. It was first described as `cylindroma' by Billroth in 1859. Half of these tumors occur in glandular tissues other than the major salivary glands; principally in the hard palate, but they can also arise in the tongue and minor salivary glands. Unusual locations include the external auditory canal, nasopharynx, lacrimal glands, breast, vulva, esophagus, cervix and Cowper glands. The long natural history of this tumor and its tendency for local recurrence are well known. JMS 2012;15(1):76-77.

Natural History of Migraine in Childhood

Cephalalgia ◽  
2000 ◽  
Vol 20 (6) ◽  
pp. 573-579 ◽  
Author(s):  
MA Hernandez-Latorre ◽  
M Roig
Keyword(s):  
Natural History ◽  
Prophylactic Treatment ◽  
Clinical Course ◽  
Age Of Onset ◽  
Statistical Significance ◽  
Positive Family History ◽  
Phenotypic Expression ◽  
Clinical Evolution ◽  
History Of ◽  
Prospective Longitudinal

Epidemiological studies have shown that 3–7% of the paediatric population suffer from migraine. Despite this high prevalence little has been published about the natural history of migraine or of its prognosis. The objectives of this study were: (i) to outline the natural history of migraine in childhood; and (ii) to identify early predictors of an unfavourable clinical evolution. A prospective, longitudinal, 10-year follow-up study was conducted of the clinical evolution of 181 paediatric patients with migraine. Data analysis was performed by statistical significance and logistic regression tests. In our study 24.3% of children with migraine had their onset before age 6 years and another 57% between 6 and 10 years of age. A positive family history of migraine was recorded in 77.5%. Eighty-eight percent of patients followed a favourable clinical course. The remaining 12% of patients had to be placed on prophylactic treatment owing to the increasing of their headache. Of all parameters investigated, the age of onset was the only statistically significant predictor of an unfavourable clinical evolution. We conclude: (i) most patients with migraine headache starting in childhood do not require prophylactic treatment; (ii) the earlier the disease begins the more likely is an unfavourable clinical course; (iii) genetic factors play an important role in the phenotypic expression of the disease; (iv) our study suggests the existence, at least, of two different populations among childhood migraine patients.

A case of multiple pial arteriovenous fistulas associated with dural arteriovenous fistula

2008 ◽  
Vol 109 (6) ◽  
pp. 1103-1107 ◽  
Author(s):  
Atsushi Saito ◽  
Takayuki Sugawara ◽  
Shigeki Mikawa ◽  
Yousuke Akamatsu ◽  
Heisuke Saito ◽  
...  
Keyword(s):  
Natural History ◽  
Treatment Strategy ◽  
Dural Arteriovenous Fistula ◽  
Perfusion Pressure ◽  
Clinical Course ◽  
Cerebrovascular Lesions ◽  
Arteriovenous Fistulas ◽  
Developmental Mechanisms ◽  
History Of ◽  
Feeding Vessels

Pial arteriovenous fistulas (AVFs) are known as rare cerebrovascular lesions. They are composed of ≥ 1 arterial feeding vessels and a single draining vein that usually has high perfusion pressure and generally occur in infants. Cases involving adults are very rare and the developmental mechanisms and natural history of these lesions remain unknown. The authors present a case of multiple pial AVFs in an adult in whom the lesions developed after radiosurgical treatment of dural AVFs. Direct disconnection of pial arterial supplies was performed, and the abnormal shunts were successfully eliminated. The authors report the clinical course of this case and discuss the characteristics of and treatment strategy for multiple pial AVFs, reviewing the published literature.

scholarly journals Effect of COVID-19 on the clinical course of diabetic ketoacidosis (DKA) in people with type 1 and type 2 diabetes

2021 ◽  
Vol 10 (4) ◽  
pp. 371-377
Author(s):  
Punith Kempegowda ◽  
Eka Melson ◽  
Agnes Johnson ◽  
Lucy Wallett ◽  
Lucretia Thomas ◽  
...  
Keyword(s):  
Natural History ◽  
Clinical Course ◽  
External Control ◽  
Multi Centre Study ◽  
Significant Difference ◽  
History Of ◽  
Using Data ◽  
Worse Prognosis

Objective COVID-19 in people with diabetes is associated with a disproportionately worse prognosis. DKA is an acute complication of diabetes with a mortality rate of approximately 0.67%. Little is known about the natural history of DKA in the presence of COVID-19. This study aimed to explore the effects of COVID-19 on presentation, clinical course and outcome in patients presenting with DKA. Design Retrospective cohort study. Methods All patients treated for DKA between 1 March 2020 and 30 May 2020 were included. Patients were categorised as COVID-positive or COVID-negative based on the swab test. A pre-COVID group was established using data from 01 March 2019 to 30 May 2019 as external control. Data regarding demographics, diabetes type, pH, bicarbonate, lactate, glucose, DKA duration, complications and outcome were collected. Results A total of 88 DKA episodes were included in this study. There was no significant difference in the severity or duration of DKA between the three groups. COVID-positive T1DM were more hyperglycaemic on admission compared to COVID-negative and pre-COVID patients. There was an over representation of T2DM in COVID-positive patients with DKA than in pre-COVID or COVID-negative groups. Conclusion COVID-19 appears to influence the natural history of DKA differently in T1DM and T2DM. Patients with T1DM and COVID-19 presented with more hyperglycaemia (60 mmol/L (35.9–60.0) vs 31.4 mmol/L (28.0–39.1) vs 24 mmol/L (20.2–33.75), respectively). Patients with T2DM were unusually presenting in DKA when infected with COVID-19 with greater ICU need and higher mortality rates. A collaborative, multi-centre study is needed to provide more definitive results.

scholarly journals Is Timing of Tracheotomy a Factor Influencing the Clinical Course in COVID-19 Patients?

2020 ◽  
pp. 014556132097414
Author(s):  
Massimo Mesolella
Keyword(s):  
Viral Load ◽  
Natural History ◽  
Clinical Course ◽  
Orotracheal Intubation ◽  
Early Tracheostomy ◽  
Risks And Benefits ◽  
Relative Risks ◽  
History Of ◽  
Complex Decision

The timing of tracheotomy is a complex decision that requires understanding of the relative risks and benefits as compared with prolonging intubation. The role of tracheotomy during the COVID-19 pandemic remains to be determined. There is no evidence that early tracheostomy improves patient’s clinical course and it is not impact on the natural history of these patients. In our opinion, the tracheotomy should be proposed in stable COVID-19 patients after 18th days after orotracheal intubation when the viral load is finished. Only in the case of patients with difficult of intubation do we perform earlier tracheotomies.

scholarly journals The Natural History and Clinical Presentation of Cervical Spondylotic Myelopathy

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Chester K. Yarbrough ◽  
Rory K. J. Murphy ◽  
Wilson Z. Ray ◽  
Todd J. Stewart
Keyword(s):  
Spinal Cord ◽  
Natural History ◽  
Cervical Spondylotic Myelopathy ◽  
Clinical Presentation ◽  
Clinical Course ◽  
The United States ◽  
Cord Compression ◽  
Asymptomatic Patients ◽  
History Of ◽  
Electrophysiologic Studies

Cervical spondylotic myelopathy (CSM) refers to impaired function of the spinal cord caused by degenerative changes of the cervical spine resulting in spinal cord compression. It is the most common disorder in the United States causing dysfunction of the spinal cord. A literature review of the natural history of mild cervical myelopathy is undertaken. Clinical presentation and current concepts of pathophysiology are also discussed. While many patients with mild signs of CSM will stabilize or improve over time with conservative treatment, the clinical course of a specific individual patient cannot be predicted. Asymptomatic patients with cervical stenosis and abnormalities on electrophysiologic studies may be at higher risk for developing myelopathy.

scholarly journals Natural history of spinal cord arteriovenous shunts: an observational study

Brain ◽  
2019 ◽  
Vol 142 (8) ◽  
pp. 2265-2275 ◽  
Author(s):  
Jia-Xing Yu ◽  
Tao Hong ◽  
Timo Krings ◽  
Chuan He ◽  
Ming Ye ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Natural History ◽  
Spontaneous Recovery ◽  
Clinical Course ◽  
Early Period ◽  
Acute Onset ◽  
Clinical Deterioration ◽  
Arteriovenous Shunts ◽  
Initial Onset ◽  
History Of

Abstract The natural history of intradural spinal cord arteriovenous shunts is unknown. We performed an observational study in a consecutive patient cohort with symptomatic intradural spinal cord arteriovenous shunts who were admitted to three institutes to investigate the clinical course of this complex disease, which would provide valuable evidence to inform clinical decision-making. The clinical course of patients with symptomatic intradural spinal cord arteriovenous shunts from initial presentation to occurrence of clinical deterioration, initiation of treatment, or last follow-up was analysed. Patients with at least 1 month of observation were included in this study. Clinical onset and deterioration patterns were divided into acute and gradual. Annual and cumulative rates of clinical deterioration as well as their risk factors were analysed using Kaplan-Meier life table analysis and Cox proportional hazards model. To assess risks and benefits of treatment, post-treatment clinical courses were further assessed. Four hundred and sixty-six patients with a mean observational period of 36.9 ± 58.8 months were included; 56.7% of patients presented with acute onset, of whom 77.3% experienced spontaneous recovery. Age of onset older than 28 years, initial modified Aminoff and Logue scale of >3, mid-thoracic lesions and non-ventral lesions were independent predictors of failure for spontaneous recovery. The annual risk of general, acute and gradual clinical deterioration after onset was 30.7%, 9.9% and 17.7%, respectively. Risk of deterioration was highest in the early period after initial onset. Acute onset was the only independent risk factor [hazard ratio 1.957 (95% confidence interval, CI 1.324–2.894); P = 0.0008] of acute deterioration and gradual onset was the strongest predictor [hazard ratio 2.350 (95% CI 1.711–3.229); P < 0.0001] of the gradual deterioration among all the stratifying factors. After invasive treatment, complete obliteration was achieved in 37.9% of patients (138 of 364) and improved or stable clinical status was noted in 80.8% of patients. Forty-two patients (11.5%) experienced permanent complications. Overall post-treatment deterioration rate was 8.4%/year, and 5.3%/year if permanent complications were excluded. The natural history of symptomatic spinal cord arteriovenous shunts is poor, especially in the early period after onset, and early intervention is thus recommended. Initial onset pattern significantly affects the natural history of the lesion, which prompts a differentiated treatment strategy.

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