Purification and reconstitution of the bile acid transport system from hepatocyte sinusoidal plasma membranes

1986 ◽  
Vol 862 (2) ◽  
pp. 352-360 ◽  
Author(s):  
Patricia von Dippe ◽  
M. Ananthanarayanan ◽  
P. Drain ◽  
Daniel Levy
Keyword(s):  
Bile Acid ◽  
Transport System ◽  
Plasma Membranes ◽  
Acid Transport ◽  
Bile Acid Transport

scholarly journals Properties of the canalicular bile acid transport system in rat liver

1987 ◽  
Vol 242 (2) ◽  
pp. 465-469 ◽  
Author(s):  
P J Meier ◽  
A S Meier-Abt ◽  
J L Boyer
Keyword(s):  
Bile Acid ◽  
Substrate Specificity ◽  
Bile Acids ◽  
Rat Liver ◽  
Transport System ◽  
Acid Transport ◽  
Bile Acid Transport ◽  
Canalicular Bile ◽  
Disulphonic Acid ◽  
Bile Acid Carrier

4,4-Di-isothiocyanostilbene-2,2′-disulphonic acid inhibition of taurocholate efflux from canalicular vesicles was used to demonstrate that potential driven and ‘carrier’-mediated canalicular excretion of taurocholate occur via a common, rather than two separate, pathways. This electrogenic canalicular bile acid ‘carrier ’ preferentially transports trihydroxylated and conjugated dihydroxylated bile acids, but not the unphysiological oxo bile acids, and possibly extends its substrate specificity to other amphipathic molecules such as sulphobromophthalein.

Negative feedback regulation of the ileal bile acid transport system in rodents

1993 ◽  
Vol 104 (1) ◽  
pp. 38-46 ◽  
Author(s):  
Jan Lillienau ◽  
Diane L. Crombie ◽  
Jorge Munoz ◽  
Sarah J. Longmire-cook ◽  
Lee R. Hagey ◽  
...  
Keyword(s):  
Bile Acid ◽  
Transport System ◽  
Negative Feedback ◽  
Feedback Regulation ◽  
Acid Transport ◽  
Negative Feedback Regulation ◽  
Bile Acid Transport

I. Hepatocyte transport of bile acids

2003 ◽  
Vol 284 (2) ◽  
pp. G175-G179 ◽  
Author(s):  
Allan W. Wolkoff ◽  
David E. Cohen
Keyword(s):  
Bile Acid ◽  
Bile Acids ◽  
Plasma Membranes ◽  
Enterohepatic Circulation ◽  
Bile Canaliculus ◽  
Transport Proteins ◽  
Acid Transport ◽  
Bile Acid Transport ◽  
The Past ◽  
The Subject

Bile acids are cholesterol derivatives that serve as detergents in bile and the small intestine. Approximately 95% of bile acids secreted by hepatocytes into bile are absorbed from the distal ileum into the portal venous system. Extraction from the portal circulation by the hepatocyte followed by reexcretion into the bile canaliculus completes the enterohepatic circulation of these compounds. Over the past few years, candidate bile acid transport proteins of the sinusoidal and canalicular plasma membranes of the hepatocyte have been identified. The physiology of hepatocyte bile acid transport and its relationship to these transport proteins is the subject of this Themes article.

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