The northern slope of Tazhong palaeo-uplift has become a key target field for petroleum exploration in Tarim Basin. A major breakthrough is made in the Upper Ordovician oil and gas exploration in the west part of northern slope. Oil and gas near the Tazhong I slope-break zone occurred in Liang2 section was dominated by condensate gas reservoir, while oil reservoir was mainly inward distributed in Liang3 section. The crude oils in this region in physical properties characterized by low density, low viscosity, low freezing point, low sulfur content, medium wax content. And the natural gas in chemical components was featured by low-medium nitrogen content, low-medium carbon dioxide content and medium-high hydrogen sulfide content. In the plane direction, oil and gas exhibited a “oil in the interior, gas in the exterior” distribution pattern, and mainly located in a depth range of 0∼60 m below the top of the Liang3 section in the longitudinal direction. The distribution patterns displayed in physical properties and chemical compositions of oil and gas are controlled by multiple influencing factors. The results of above comprehensive studies suggested that vertical overriding of reef-bank-type reservoirs in Liang2 section and karst reservoirs in Liang3 section provided superior reservoir conditions; faults and fractures not only formed reservoir space and improved reservoir quality, also promoted the development of karst reservoirs and provided good migration pathway for hydrocarbon accumulation; one of the nonnegligible factors leading to this kind of distribution pattern for the Upper Ordovician oil and gas reservoirs is shale content in the compact carbonate formation; multi-sources and multi-stages of hydrocarbon filling are absolutely necessary controlling factor for this kind of distribution pattern in the whole block.