A ‘hexokinase effect’ in the inhibition of oxidative phosphorylation in heart muscle mitochondria by Adriamycin

1982 ◽  
Vol 105 (4) ◽  
pp. 1440-1445 ◽  
Author(s):  
H. Muhammed ◽  
T. Ramasarma ◽  
C.K.Ramakrishna Kurup
Keyword(s):  
Oxidative Phosphorylation ◽  
Heart Muscle ◽  
Muscle Mitochondria

scholarly journals Efficiency of Oxidative Phosphorylation of Heart Muscle Mitochondria from Digitalized Guinea Pigs

1957 ◽  
Vol 5 (3) ◽  
pp. 226-229 ◽  
Author(s):  
KATHARINE ARMSTRONG PLAUT ◽  
MENARD M. GERTLER ◽  
G. W. E. PLAUT
Keyword(s):  
Oxidative Phosphorylation ◽  
Heart Muscle ◽  
Guinea Pigs ◽  
Muscle Mitochondria

Oxidative phosphorylation by heart muscle mitochondria

1954 ◽  
Vol 14 ◽  
pp. 443-444 ◽  
Author(s):  
Gladys Feldott Maley ◽  
G.W.E. Plaut
Keyword(s):  
Oxidative Phosphorylation ◽  
Heart Muscle ◽  
Muscle Mitochondria

65 Fatty acid oxidation in human skeletal muscle mitochondria determined by oxidative phosphorylation as a function of age

Mitochondrion ◽  
2007 ◽  
Vol 7 (6) ◽  
pp. 422-423
Author(s):  
George Kypriotakis ◽  
Bruce H. Cohen ◽  
Sumit Parikh ◽  
Douglas S. Kerr ◽  
Charles L. Hoppel ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Fatty Acid ◽  
Oxidative Phosphorylation ◽  
Fatty Acid Oxidation ◽  
Human Skeletal Muscle ◽  
Acid Oxidation ◽  
Muscle Mitochondria ◽  
Skeletal Muscle Mitochondria

Effect of ouabain on potassium exchange in heart muscle mitochondria

1960 ◽  
Vol 198 (1) ◽  
pp. 89-93 ◽  
Author(s):  
Sidney S. Schreiber ◽  
Murray Oratz ◽  
Marcus A. Rothschild
Keyword(s):  
Heart Muscle ◽  
Major Part ◽  
Specific Effect ◽  
Ventricular Failure ◽  
Muscle Mitochondria ◽  
Potassium Exchange ◽  
Frog Ventricle ◽  
Control State

Potassium in the working frog ventricle exists in two physiological compartments and the more slowly exchanging compartment is influenced by the amount of work performed, ventricular failure and ouabain. In the present study, the exchange of potassium in mitochondria is investigated both in the control state and after exposure to ouabain, in order to determine whether mitochondria potassium represents the slowly exchanging compartment. Mitochondria potassium represents only 15% of the total ventricular potassium, while the slowly exchanging phase contains about 50%. Ouabain perfusion is associated with inhibition of entrance of potassium into the slowly exchanging ventricular phase, but no isolated specific effect on the mitochondria potassium is found. Alterations in mitochondria potassium directly reflect changes within the total ventricle. A fraction of mitochondria potassium is found to be inexchangeable under the conditions of the experiment. The results indicate that mitochondria potassium does not represent the major part of the slowly exchanging compartment.

A magnesium-responsive defect of respiration and oxidative phosphorylation in skeletal muscle mitochondria of dystrophic hamsters

1970 ◽  
Vol 48 (12) ◽  
pp. 1332-1338 ◽  
Author(s):  
K. Wrogemann ◽  
M. C. Blanchaer ◽  
B. E. Jacobson
Keyword(s):  
Skeletal Muscle ◽  
Oxidative Phosphorylation ◽  
Respiratory Rate ◽  
Test System ◽  
Muscle Mitochondria ◽  
Skeletal Muscle Mitochondria ◽  
Muscle Necrosis ◽  
Presence And Absence ◽  
Stimulation Of

Skeletal muscle mitochondria were isolated in the presence and absence of the proteinase Nagarse from dystrophic hamsters of the BIO 14.6 strain, aged 45–196 days, and from normal hamsters. Mitochondria from the dystrophic animals prepared by glass-on-glass homogenization without Nagarse in 0.25 M sucrose – 1 mM EDTA, pH 7.4, did not differ from normal in their respiratory rate or capacity for oxidative phosphorylation. However, these functions were subnormal in mitochondria isolated with Nagarse from the same animals, both in the presence and absence of albumin. Respiration measured with an O2 electrode was reduced by 50–70% and the stimulation of O2 uptake normally seen after ADP addition was minimal or absent. This was most marked in mitochondria from young hamsters about 65 days old with muscle necrosis. The defect was ameliorated by addition to the Polarographie test system of an ATP trap or of Mg2+, one of the trap constituents. This ion, when added to the defective mitochondria prior to ADP and substrate, restored respiration and oxidative phosphorylation to values that did not differ significantly from those found with skeletal muscle mitochondria of normal hamsters.

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