Photoaffinity labeling of gonadotropin releasing hormone receptors in control and desensitized pituitary cells

1984 ◽  
Vol 125 (2) ◽  
pp. 532-538 ◽  
Author(s):  
E. Hazum ◽  
I. Schvartz
Keyword(s):  
Hormone Receptors ◽  
Photoaffinity Labeling ◽  
Gonadotropin Releasing Hormone ◽  
Pituitary Cells ◽  
Releasing Hormone

Gonadotropin-Releasing Hormone and GnRH Receptor: Structure, Function and Drug Development

2020 ◽  
Vol 27 (36) ◽  
pp. 6136-6158 ◽  
Author(s):  
Haralambos Tzoupis ◽  
Agathi Nteli ◽  
Maria-Eleni Androutsou ◽  
Theodore Tselios
Keyword(s):  
Hormone Receptors ◽  
Gnrh Receptor ◽  
Gonadotropin Releasing Hormone ◽  
Human Organism ◽  
Valuable Insight ◽  
Pituitary Cells ◽  
Treatment Protocols ◽  
Gnrh Analogues ◽  
Releasing Hormone ◽  
Functional Studies

Background: Gonadotropin-Releasing Hormone (GnRH) is a key element in sexual maturation and regulation of the reproductive cycle in the human organism. GnRH interacts with the pituitary cells through the activation of the Gonadotropin Releasing Hormone Receptors (GnRHR). Any impairments/dysfunctions of the GnRH-GnRHR complex lead to the development of various cancer types and disorders. Furthermore, the identification of GnRHR as a potential drug target has led to the development of agonist and antagonist molecules implemented in various treatment protocols. The development of these drugs was based on the information derived from the functional studies of GnRH and GnRHR. Objective: This review aims at shedding light on the versatile function of GnRH and GnRH receptor and offers an apprehensive summary regarding the development of different agonists, antagonists and non-peptide GnRH analogues. Conclusion: The information derived from these studies can enhance our understanding of the GnRH-GnRHR versatile nature and offer valuable insight into the design of new more potent molecules.

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