Homologous regulation of gonadotropin-releasing hormone receptors in cultured pituitary cells

Science ◽  
1982 ◽  
Vol 215 (4535) ◽  
pp. 983-985 ◽  
Author(s):  
E Loumaye ◽  
K. Catt
Keyword(s):  
Hormone Receptors ◽  
Gonadotropin Releasing Hormone ◽  
Pituitary Cells ◽  
Releasing Hormone

Characterization of Gonadotropin-Releasing Hormone Receptors in Cultured Rat Pituitary Cells

Endocrinology ◽  
1980 ◽  
Vol 107 (4) ◽  
pp. 1144-1152 ◽  
Author(s):  
ZVI NAOR ◽  
RICHARD N. CLAYTON ◽  
KEVIN J. CATT
Keyword(s):  
Hormone Receptors ◽  
Gonadotropin Releasing Hormone ◽  
Pituitary Cells ◽  
Releasing Hormone ◽  
Rat Pituitary ◽  
Rat Pituitary Cells

Gonadotropin-Releasing Hormone and GnRH Receptor: Structure, Function and Drug Development

2020 ◽  
Vol 27 (36) ◽  
pp. 6136-6158 ◽  
Author(s):  
Haralambos Tzoupis ◽  
Agathi Nteli ◽  
Maria-Eleni Androutsou ◽  
Theodore Tselios
Keyword(s):  
Hormone Receptors ◽  
Gnrh Receptor ◽  
Gonadotropin Releasing Hormone ◽  
Human Organism ◽  
Valuable Insight ◽  
Pituitary Cells ◽  
Treatment Protocols ◽  
Gnrh Analogues ◽  
Releasing Hormone ◽  
Functional Studies

Background: Gonadotropin-Releasing Hormone (GnRH) is a key element in sexual maturation and regulation of the reproductive cycle in the human organism. GnRH interacts with the pituitary cells through the activation of the Gonadotropin Releasing Hormone Receptors (GnRHR). Any impairments/dysfunctions of the GnRH-GnRHR complex lead to the development of various cancer types and disorders. Furthermore, the identification of GnRHR as a potential drug target has led to the development of agonist and antagonist molecules implemented in various treatment protocols. The development of these drugs was based on the information derived from the functional studies of GnRH and GnRHR. Objective: This review aims at shedding light on the versatile function of GnRH and GnRH receptor and offers an apprehensive summary regarding the development of different agonists, antagonists and non-peptide GnRH analogues. Conclusion: The information derived from these studies can enhance our understanding of the GnRH-GnRHR versatile nature and offer valuable insight into the design of new more potent molecules.

scholarly journals Endocrine and molecular milieus of ovarian follicles are diversely affected by human chorionic gonadotropin and gonadotropin-releasing hormone in prepubertal and mature gilts

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Adam J. Ziecik ◽  
Jan Klos ◽  
Katarzyna Gromadzka-Hliwa ◽  
Mariola A. Dietrich ◽  
Mariola Slowinska ◽  
...  
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Hormone Receptors ◽  
Cell Function ◽  
Ovarian Follicle ◽  
Molecular Transport ◽  
Gonadotropin Releasing Hormone ◽  
Matrix Remodeling ◽  
Releasing Hormone ◽  
Serum Gonadotropin

AbstractDifferent strategies are used to meet optimal reproductive performance or manage reproductive health. Although exogenous human chorionic gonadotropin (hCG) and gonadotropin-releasing hormone (GnRH) agonists (A) are commonly used to trigger ovulation in estrous cycle synchronization, little is known about their effect on the ovarian follicle. Here, we explored whether hCG- and GnRH-A-induced native luteinizing hormone (LH) can affect the endocrine and molecular milieus of ovarian preovulatory follicles in pigs at different stages of sexual development. We collected ovaries 30 h after hCG/GnRH-A administration from altrenogest and pregnant mare serum gonadotropin (eCG)-primed prepubertal and sexually mature gilts. Several endocrine and molecular alternations were indicated, including broad hormonal trigger-induced changes in follicular fluid steroid hormones and prostaglandin levels. However, sexual maturity affected only estradiol levels. Trigger- and/or maturity-dependent changes in the abundance of hormone receptors (FSHR and LHCGR) and proteins associated with lipid metabolism and steroidogenesis (e.g., STAR, HSD3B1, and CYP11A1), prostaglandin synthesis (PTGS2 and PTGFS), extracellular matrix remodeling (MMP1 and TIMP1), protein folding (HSPs), molecular transport (TF), and cell function and survival (e.g., VIM) were observed. These data revealed different endocrine properties of exogenous and endogenous gonadotropins, with a potent progestational/androgenic role of hCG and estrogenic/pro-developmental function of LH.

Demonstration of gonadotropin releasing-hormone receptors on gonadotrophs and somatotrophs of the goldfish: an electron microscope study

1991 ◽  
Vol 36 (3) ◽  
pp. 369-378 ◽  
Author(s):  
Harry Cook ◽  
John W. Berkenbosch ◽  
Mark J. Fernhout ◽  
Kei-Li Yu ◽  
Richard E. Peter ◽  
...  
Keyword(s):  
Electron Microscope ◽  
Microscope Study ◽  
Electron Microscope Study ◽  
Hormone Receptors ◽  
Gonadotropin Releasing Hormone ◽  
Releasing Hormone
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