Spin-trapping of superoxide ion by a water-soluble, nitroso-aromatic spin-trap

1986 ◽  
Vol 136 (2) ◽  
pp. 657-664 ◽  
Author(s):  
Toshihiko Ozawa ◽  
Akira Hanaki
Keyword(s):  
Spin Trap ◽  
Spin Trapping ◽  
Water Soluble ◽  
Superoxide Ion

From early spin-trapping experiments to acyl nitroxide chemistry: synthesis of and spin trapping with a water-soluble nitrosopyrazole derivative

1982 ◽  
Vol 60 (12) ◽  
pp. 1587-1593 ◽  
Author(s):  
M John Perkins ◽  
Harparkash Kaur
Keyword(s):  
Spin Trap ◽  
Preliminary Investigation ◽  
Spin Trapping ◽  
Water Soluble ◽  
Nitroso Compounds ◽  
Nitroxide Radicals ◽  
Personal View ◽  
Spin Traps ◽  
Subsequent Investigation

A personal view of early experiments which led to the use of C-nitroso-compounds as spin traps is presented, and it is shown how these experiments resulted in the first isolation, and subsequent investigation, of acyl nitroxide radicals: the use of 1-methyl-4-nitroso-3,5-diphenylpyrazole as a spin trap, and the preparation and preliminary investigation of its water-soluble analogue (1) are described.

Lyoluminescence and spin trapping

1982 ◽  
Vol 60 (12) ◽  
pp. 1549-1559 ◽  
Author(s):  
Kamil V Ettinger ◽  
Alexander R Forrester ◽  
Charles H Hunter
Keyword(s):  
Spin Trap ◽  
Light Yield ◽  
Spin Trapping ◽  
Water Soluble ◽  
Peroxyl Radicals ◽  
Nitroso Compounds ◽  
Γ Irradiation ◽  
Alkyl Radicals ◽  
Emitting Species ◽  
Aromatic Nitroso Compounds

The chemical origin of lyoluminescence has been probed using spin trapping techniques. Radicals derived from amino acids and saccharides by γ-irradiation in the solid state have been identified after trapping with aliphatic and aromatic nitroso compounds. Most of the radicals trapped were secondary alkyl radicals. Reaction of peroxyl radicals derived therefrom are thought to produce the emitting species (excited carbonyl compound and/or singlet oxygen). The effect which thermal annealing of the solids after γ-irradiation has on (a) the concentration of radicals in the solid, (b) the concentration of trapped radicals, and (c) the light yield has been investigated. One new water-soluble spin trap has been prepared.

scholarly journals Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals

The Analyst ◽  
2019 ◽  
Vol 144 (14) ◽  
pp. 4194-4203 ◽  
Author(s):  
Eric Besson ◽  
Stéphane Gastaldi ◽  
Emily Bloch ◽  
Jacek Zielonka ◽  
Monika Zielonka ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Radical Anion ◽  
Superoxide Radical ◽  
Spin Trap ◽  
Aqueous Media ◽  
Spin Trapping ◽  
Silica Particles ◽  
Superoxide Radical Anion ◽  
Wide Range ◽  
Epr Spin Trapping

Mesoporous silica functionalised with a cyclic spin trap enabled the identification of a wide range of radicals in organic and aqueous media, including superoxide radical anion.

scholarly journals The spin trapping of pyrimidine nucleotide free radicals in a Fenton system

1989 ◽  
Vol 261 (3) ◽  
pp. 831-839 ◽  
Author(s):  
W D Flitter ◽  
R P Mason
Keyword(s):  
Free Radicals ◽  
Hydroxyl Radical ◽  
Spin Trap ◽  
Gamma Ray ◽  
Thiobarbituric Acid ◽  
Spin Trapping ◽  
Pyrimidine Nucleotide ◽  
Gamma Ray Irradiation ◽  
Radical Attack ◽  
Fenton System

The reaction of the hydroxyl radical, generated by a Fenton system, with pyrimidine deoxyribonucleotides was investigated by using the e.s.r. technique of spin trapping. The spin trap t-nitrosobutane was employed to trap secondary radicals formed by the reaction of the hydroxyl radical with these nucleotides. The results presented here show that hydroxyl-radical attack on thymidine, 2-deoxycytidine 5-monophosphate and 2-deoxyuridine 5-monophosphate produced nucleotide-derived free radicals. The results indicate that .OH radical attack occurs predominantly at the carbon-carbon double bond of the pyrimidine base. The e.s.r. studies showed a good correlation with previous results obtained by authors who used x- or gamma-ray irradiation to generate the hydroxyl radical. A thiobarbituric acid assay was also used to monitor the damage produced to the nucleotides by the Fenton system. These results showed qualitative agreement with the spin-trapping studies.

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