Defective cyclic GMP accumulation in spontaneously hypertensive rat aorta in response to atrial natriuretic factor

1988 ◽  
Vol 37 (11) ◽  
pp. 2109-2112 ◽  
Author(s):  
Marie Donabella Sauro ◽  
David F. Fitzpatrick ◽  
Ronald G. Coffey
Keyword(s):  
Cyclic Gmp ◽  
Atrial Natriuretic Factor ◽  
Spontaneously Hypertensive Rat ◽  
Rat Aorta ◽  
Spontaneously Hypertensive ◽  
Natriuretic Factor ◽  
Hypertensive Rat ◽  
Atrial Natriuretic

Atrial Natriuretic Factor in Central Cardiovascular Control

Physiology ◽  
1993 ◽  
Vol 8 (5) ◽  
pp. 223-228 ◽  
Author(s):  
S Oparil ◽  
JM Wyss
Keyword(s):  
Atrial Natriuretic Factor ◽  
Spontaneously Hypertensive Rat ◽  
Brain Regions ◽  
Baroreceptor Reflex ◽  
Hypothalamic Area ◽  
Spontaneously Hypertensive ◽  
Natriuretic Factor ◽  
Effector System ◽  
Baroreceptor Reflex Sensitivity ◽  
Atrial Natriuretic

A complete atrial natriuretic factor (ANF) synthetic, processing, and effector system is found in rat brain. ANF in critical brain regions, including anterior hypothalamic area and nucleus tractus solitarii, contributes importantly to the tonic control of blood pressure, sympathetic outflow, and baroreceptor reflex sensitivity in the spontaneously hypertensive rat.

Effect of natural and synthetic atrial natriuretic factor on arterial blood pressure, natriuresis and cyclic GMP excretion in spontaneously hypertensive rats

1985 ◽  
Vol 69 (6) ◽  
pp. 721-726 ◽  
Author(s):  
Stephen C. Pang ◽  
Minh-Chau Hoang ◽  
Johanne Tremblay ◽  
Marc Cantin ◽  
Raul Garcia ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Blood Pressure ◽  
Cyclic Gmp ◽  
Atrial Natriuretic Factor ◽  
Blood Pressure Lowering Effect ◽  
Spontaneously Hypertensive ◽  
Arterial Blood ◽  
Natriuretic Factor ◽  
Pressure Natriuresis ◽  
Atrial Natriuretic

1. The differential effects of extracted and synthetic atrial natriuretic factor (ANF) on arterial blood pressure, natriuresis, and cyclic GMP excretion were studied in normotensive (WKY) and spontaneously hypertensive (SHR and SHRSP) rats. 2. Atrial extracts or synthetic (101–126)-ANF decreased arterial blood pressure in all tested animals, but the blood pressure-lowering effect was more pronounced in hypertensive than in normotensive rats. ANF-induced diuresis and natriuresis were two- to three-fold higher in the hypertensive groups. However, a several-fold increase in total urinary cyclic GMP level after the infusion of ANF was essentially equal in the three groups. 3. Our data suggest that acute infusion of ANF reveals a defect of sodium and water handling in SHR. It is possible that this defect is located at the distal nephron, and is made apparent by the action of ANF on glomeruli via a cyclic GMP-induced vascular effect.

Effects of atrial natriuretic factor, sodium nitroprusside, and acetylcholine on cyclic GMP levels and relaxation in rat aorta

1985 ◽  
Vol 115 (2-3) ◽  
pp. 219-229 ◽  
Author(s):  
Robert M. Rapoport ◽  
Scott A. Waldman ◽  
Karen Schwartz ◽  
Raymond J. Winquist ◽  
Ferid Murad
Keyword(s):  
Sodium Nitroprusside ◽  
Cyclic Gmp ◽  
Atrial Natriuretic Factor ◽  
Rat Aorta ◽  
Natriuretic Factor ◽  
Atrial Natriuretic
Sign in / Sign up

Export Citation Format

Share Document