Comparison of effects of electrical stimulation of preoptic area, anterior hypothalamus and dorsal raphe nucleus on 5-hydroxyindoleacetic acid in cerebrospinal fluid and behavior

1974 ◽  
Vol 67 (3) ◽  
pp. 542-545 ◽  
Author(s):  
M. Radulovacˇki ◽  
G. Karmos
1990 ◽  
Vol 10 (1) ◽  
pp. 123-126 ◽  
Author(s):  
G. Bonvento ◽  
P. Lacombe ◽  
E. T. MacKenzie ◽  
L. Rouquier ◽  
B. Scatton ◽  
...  

The levels of noradrenaline (NA), serotonin (5-HT), and 5-hydroxyindoleacetic acid were measured by HPLC and compared between the large arteries of the circle of Willis and the small pial vessels in the rat, following either electrical stimulation of the dorsal raphe nucleus or bilateral superior cervical ganglionectomy. With electrical stimulation, the 5-HT concentrations were reduced (– 48%) in the small pial vessels, but were unchanged in the major cerebral arteries. NA concentrations were dramatically reduced following cervical sympathectomy in the large arteries (– 77%), though the reduction was less pronounced (– 34%) in the small vessels. Sympathectomy caused a significant decrease in the 5-HT concentration of the major cerebral arteries (–33%), but was without effect on the 5-HT levels of the small pial vessels. These results show that an appreciable fraction of the perivascular 5-HT measured in the small pial and the large cerebral arteries originates from different sources.


2010 ◽  
Vol 26 (5) ◽  
pp. 388-394 ◽  
Author(s):  
Sheikhkanloui-Milan Hamid ◽  
Sheibani Vahid ◽  
Afarinesh Mohammadreza ◽  
Esmaeili-Mahani Saeed ◽  
Shamsizadeh Ali ◽  
...  

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