Neurotensin, a central nervous system peptide: apparent receptor binding in brain membranes

1977 ◽  
Vol 130 (2) ◽  
pp. 299-313 ◽  
Author(s):  
George R. Uhl ◽  
James P. Bennett ◽  
Solomon H. Snyder
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Receptor Binding ◽  
Brain Membranes

Calcitonin gene-related peptide (CGRP) in the rat central nervous system: patterns of immunoreactivity and receptor binding sites

1988 ◽  
Vol 463 (2) ◽  
pp. 223-244 ◽  
Author(s):  
Lawrence Kruger ◽  
Patrick W. Mantyh ◽  
Catia Sternini ◽  
Nicholas C. Brecha ◽  
Christopher R. Mantyh
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Receptor Binding ◽  
Binding Sites ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Calcitonin Gene

scholarly journals Narcotic Dosage and Central Nervous System Opiate Receptor Binding

1983 ◽  
Vol 62 (8) ◽  
pp. 705???709 ◽  
Author(s):  
Theodore H. Stanley ◽  
Josee Leysen ◽  
Carlos J. E. Niemegeers ◽  
Nathan L. Pace
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Receptor Binding ◽  
Opiate Receptor

Imidazo[1,2-b]Pyridazines. XIX. Syntheses and Central Nervous System Activities of Some 6-Arylthio(aryloxy and alkylthio)-3-(acetamidomethyl, benzamidomethyl, methoxy and unsubstituted)-2-arylimidazo[1,2-b]pyridazines

1996 ◽  
Vol 49 (4) ◽  
pp. 443 ◽  
Author(s):  
GB Barlin ◽  
LP Davies ◽  
SJ Ireland
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Rat Brain ◽  
Active Compound ◽  
Binding Ability ◽  
Brain Membranes ◽  
Rat Brain Membranes

Some 6-arylthio( aryloxy and alkylthio )-3-( acetamidomethyl , benzamidomethyl, methoxy and unsubstituted )-2-arylimidazo[1,2-b] pyridazines have been prepared and examined for their ability to displace [3H]diazepam from rat brain membranes. The most active compound was 3-acetamidomethyl-2-(3',4'-methylenedioxyphenyl)-6-phenylthioimidazo[1,2-b] pyridazine with IC50 4.4 nM. The 3-acylaminomethyl-6-(2- and 3-methoxyphenylthio)-2-phenylimidazo[1,2-b] pyridazines proved less active than their 6-phenylthio analogues, and larger substituents at the 2- and 6-positions markedly decreased binding. Significant differences in binding ability have been observed between 3-acylaminomethyl-2-aryl-6-phenylthioimidazo[1,2-b] pyridazines and the corresponding imidazo [1,2-a]pyridines.

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