Open-field behavior of rats previously subjected to short-term hyperbilirubinemia with or without blood-brain barrier manipulations

1987 ◽  
Vol 424 (1) ◽  
pp. 26-36 ◽  
Author(s):  
Thor Willy Ruud Hansen ◽  
Terje Sagvolden ◽  
Dag Bratlid
Keyword(s):  
Open Field ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Short Term ◽  
Open Field Behavior ◽  
Field Behavior ◽  
Blood Brain ◽  
Behavior Of Rats

Benzophenone-3 Passes Through the Blood-Brain Barrier, Increases the Level of Extracellular Glutamate, and Induces Apoptotic Processes in the Hippocampus and Frontal Cortex of Rats

2019 ◽  
Vol 171 (2) ◽  
pp. 485-500 ◽  
Author(s):  
Bartosz Pomierny ◽  
Weronika Krzyżanowska ◽  
Żaneta Broniowska ◽  
Beata Strach ◽  
Beata Bystrowska ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Blood Brain Barrier ◽  
Brain Structures ◽  
Glutamate Transporters ◽  
Brain Barrier ◽  
Short Term ◽  
Extracellular Glutamate ◽  
Blood Brain ◽  
The Impact ◽  
The Brain

Abstract Benzophenone-3 is the most commonly used UV filter. It is well absorbed through the skin and gastrointestinal tract. Its best-known side effect is the impact on the function of sex hormones. Little is known about the influence of BP-3 on the brain. The aim of this study was to show whether BP-3 crosses the blood-brain barrier (BBB), to determine whether it induces nerve cell damage in susceptible brain structures, and to identify the mechanism of its action in the central nervous system. BP-3 was administered dermally during the prenatal period and adulthood to rats. BP-3 effect on short-term and spatial memory was determined by novel object and novel location recognition tests. BP-3 concentrations were assayed in the brain and peripheral tissues. In brain structures, selected markers of brain damage were measured. The study showed that BP-3 is absorbed through the rat skin, passes through the BBB. BP-3 raised oxidative stress and induced apoptosis in the brain. BP-3 increased the concentration of extracellular glutamate in examined brain structures and changed the expression of glutamate transporters. BP-3 had no effect on short-term memory but impaired spatial memory. The present study showed that dermal BP-3 exposure may cause damage to neurons what might be associated with the increase in the level of extracellular glutamate, most likely evoked by changes in the expression of GLT-1 and xCT glutamate transporters. Thus, exposure to BP-3 may be one of the causes that increase the risk of developing neurodegenerative diseases.

Systemic administration of endorphins selectively alters open field behavior of rats

1978 ◽  
Vol 20 (5) ◽  
pp. 539-542 ◽  
Author(s):  
Jane L. Veith ◽  
Curt A Sandman ◽  
J. Michael Walker ◽  
David H. Coy ◽  
Abba J. Kastin
Keyword(s):  
Open Field ◽  
Systemic Administration ◽  
Open Field Behavior ◽  
Field Behavior ◽  
Behavior Of Rats

Septal lesion, sex, and incentive shift effects on open field behavior of rats

1979 ◽  
Vol 22 (5) ◽  
pp. 903-909 ◽  
Author(s):  
Charles F. Flaherty ◽  
Gerald Powell ◽  
Leonard W. Hamilton
Keyword(s):  
Open Field ◽  
Septal Lesion ◽  
Open Field Behavior ◽  
Field Behavior ◽  
Behavior Of Rats

Digestive transit time and open-field behavior of rats

1966 ◽  
Vol 1 (2) ◽  
pp. 125-131 ◽  
Author(s):  
E. Tobach ◽  
H.S. Berman ◽  
P.S. Gold ◽  
K. Thomas ◽  
R. Haber
Keyword(s):  
Open Field ◽  
Transit Time ◽  
Open Field Behavior ◽  
Field Behavior ◽  
Behavior Of Rats

Open field behavior of rats after bilateral coagulation of the locus coeruleus

1987 ◽  
Vol 104 (3) ◽  
pp. 1243-1245
Author(s):  
E. I. Ivanov ◽  
Z. Oprshalova ◽  
M. Dobrakovova ◽  
T. I. Belova ◽  
R. Kvetnansky
Keyword(s):  
Locus Coeruleus ◽  
Open Field ◽  
Open Field Behavior ◽  
Field Behavior ◽  
Behavior Of Rats
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