Special properties of cholinesterases in the cerebral cortex of Alzheimer's disease

1989 ◽  
Vol 498 (1) ◽  
pp. 185-189 ◽  
Author(s):  
Changiz Geula ◽  
Marsel Mesulam
1995 ◽  
Vol 90 (4) ◽  
pp. 356-365 ◽  
Author(s):  
M. A. Mor�n ◽  
A. Probst ◽  
C. Navarro ◽  
P. G�mez-Ramos

Gerontology ◽  
1987 ◽  
Vol 33 (3-4) ◽  
pp. 197-202 ◽  
Author(s):  
Sandro Sorbi ◽  
Silvia Piacentini ◽  
Luigi Amaducci

1993 ◽  
Vol 85 (4) ◽  
pp. 400-403 ◽  
Author(s):  
H. Akiyama ◽  
T. Yamada ◽  
P. L. McGeer ◽  
T. Kawamata ◽  
I. Tooyama ◽  
...  

2020 ◽  
Vol 21 (12) ◽  
pp. 4443
Author(s):  
Hiroyuki Shimada ◽  
Shinobu Minatani ◽  
Jun Takeuchi ◽  
Akitoshi Takeda ◽  
Joji Kawabe ◽  
...  

We previously identified a novel mutation in amyloid precursor protein from a Japanese pedigree of familial Alzheimer’s disease, FAD (Osaka). Our previous positron emission tomography (PET) study revealed that amyloid β (Aβ) accumulation was negligible in two sister cases of this pedigree, indicating a possibility that this mutation induces dementia without forming senile plaques. To further explore the relationship between Aβ, tau and neurodegeneration, we performed tau and Aβ PET imaging in the proband of FAD (Osaka) and in patients with sporadic Alzheimer’s disease (SAD) and healthy controls (HCs). The FAD (Osaka) patient showed higher uptake of tau PET tracer in the frontal, lateral temporal, and parietal cortices, posterior cingulate gyrus and precuneus than the HCs (>2.5 SD) and in the lateral temporal and parietal cortices than the SAD patients (>2 SD). Most noticeably, heavy tau tracer accumulation in the cerebellum was found only in the FAD (Osaka) patient. Scatter plot analysis of the two tracers revealed that FAD (Osaka) exhibits a distinguishing pattern with a heavy tau burden and subtle Aβ accumulation in the cerebral cortex and cerebellum. These observations support our hypothesis that Aβ can induce tau accumulation and neuronal degeneration without forming senile plaques.


Cell Calcium ◽  
2011 ◽  
Vol 49 (4) ◽  
pp. 208-216 ◽  
Author(s):  
Sophie Sokolow ◽  
Sanh H. Luu ◽  
Alison J. Headley ◽  
Alecia Y. Hanson ◽  
Taeree Kim ◽  
...  

2016 ◽  
Vol 12 ◽  
pp. P386-P386
Author(s):  
Erming Wang ◽  
Haihao Zhu ◽  
Adam Gower ◽  
Jan Krzysztof Blusztajn ◽  
Neil W. Kowall ◽  
...  

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