Stereoselective reduction of (R)-()-carvone with sodium dithionite in the presence of cyclomaltoheptaose (β-cyclodextrin) and its heptakis(2,6-di-O-methyl) derivative

1991 ◽  
Vol 217 ◽  
pp. 245-249 ◽  
Author(s):  
Roberto Fornasier ◽  
Franco Marcuzzi ◽  
Michele Parmagnani ◽  
Umberto Tonellato
1988 ◽  
Vol 53 (8) ◽  
pp. 1806-1811 ◽  
Author(s):  
Zdeněk Polívka ◽  
Jan Metyš ◽  
Miroslav Protiva

Reactions of 11-chloro-6,11-dihydrodibenzo[b,e]thiepin and its 2-methyl derivative, and further of the methanesulfonates of 2-chloro- and 2-bromo-6,11-dihydrodibenzo[b,e]thiepin-11-ol with 3-quinuclidinol afforded the title ethers I-IV. The 2-methyl compound II (VÚFB-17 088) showed significant antihistamine activity and the 2-chloro compound III (VÚFB-17 089), having antireserpine and anticataleptic activity, proved a potential antidepressant agent.


Author(s):  
Jeroen A. van Bokhoven ◽  
Andrea N. Blankenship ◽  
Manoj Ravi ◽  
Mark A. Newton

2007 ◽  
Vol 62 (11) ◽  
pp. 1453-1458 ◽  
Author(s):  
Yusuf M. Al-Hiari ◽  
Ali M. Qaisia ◽  
Mohammad Y.Abu Shuheil ◽  
Mustafa M. El-Abadelah ◽  
Wolfgang Voelter

The reaction of 7-chloro-1-cyclopropyl-6-fluoro-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (7) with each of sarcosine and (±)-pipecolinic acid afforded the corresponding N-(4- oxoquinolin-7-yl)-α-amino acids 8 and 9. Reductive lactamization of the latter with sodium dithionite gave hexahydropyrido[2,3- f ]quinoxaline (10) and octahydrodipyrido[1,2-a : 2,3- f ]quinoxaline (11) derivatives, respectively. Compounds 8 - 11 and their homologs 1 - 6, accessible from (S)-proline, (2S, 4R)-4-hydroxyproline and (S)-tetrahydroisoquinoline-3-carboxylic acid exhibit good to excellent antibacterial activities against E. coli and S. aureus.


Langmuir ◽  
1996 ◽  
Vol 12 (20) ◽  
pp. 4966-4968 ◽  
Author(s):  
Jan Czapkiewicz ◽  
Patrycja Dynarowicz ◽  
Piotr Milart

1992 ◽  
Vol 33 (20) ◽  
pp. 2825-2828 ◽  
Author(s):  
Shigeyasu Kuroda ◽  
Jun-ichi Yazaki ◽  
Sunao Maeda ◽  
Kazuo Yamazaki ◽  
Masaki Yamada ◽  
...  
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