Nitric oxide and prostacyclin modulate the alterations in cardiac action potential duration mediated by platelets during ischaemia

1995 ◽  
Vol 30 (5) ◽  
pp. 788-798 ◽  
Author(s):  
N Goulielmos
Keyword(s):  
Nitric Oxide ◽  
Action Potential ◽  
Action Potential Duration ◽  
Cardiac Action Potential ◽  
Cardiac Action ◽  
Cardiac Action Potential Duration

scholarly journals Beat-to-beat variability of cardiac action potential duration: underlying mechanism and clinical implications

2017 ◽  
Vol 95 (10) ◽  
pp. 1230-1235 ◽  
Author(s):  
Péter P. Nánási ◽  
János Magyar ◽  
András Varró ◽  
Balázs Ördög
Keyword(s):  
Action Potential ◽  
Action Potential Duration ◽  
Feedback Regulation ◽  
Underlying Mechanism ◽  
Cardiac Action Potential ◽  
Clinical Implications ◽  
Cell Coupling ◽  
Negative Feedback Regulation ◽  
Cardiac Action ◽  
Cardiac Action Potential Duration

Beat-to-beat variability of cardiac action potential duration (short-term variability, SV) is a common feature of various cardiac preparations, including the human heart. Although it is believed to be one of the best arrhythmia predictors, the underlying mechanisms are not fully understood at present. The magnitude of SV is basically determined by the intensity of cell-to-cell coupling in multicellular preparations and by the duration of the action potential (APD). To compensate for the APD-dependent nature of SV, the concept of relative SV (RSV) has been introduced by normalizing the changes of SV to the concomitant changes in APD. RSV is reduced by ICa, IKr, and IKs while increased by INa, suggesting that ion currents involved in the negative feedback regulation of APD tend to keep RSV at a low level. RSV is also influenced by intracellular calcium concentration and tissue redox potential. The clinical implications of APD variability is discussed in detail.

scholarly journals Cardiac action potential duration and contractility in the intact dog heart.

1983 ◽  
Vol 345 (1) ◽  
pp. 75-85 ◽  
Author(s):  
A J Drake-Holland ◽  
M I Noble ◽  
M Pieterse ◽  
V J Schouten ◽  
W A Seed ◽  
...  
Keyword(s):  
Action Potential ◽  
Action Potential Duration ◽  
Cardiac Action Potential ◽  
Dog Heart ◽  
Cardiac Action ◽  
Cardiac Action Potential Duration
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