Endothelin-1 can reduce infarct size through protein kinase C and KATP channels in the isolated rat heart

1996 ◽  
Vol 32 (5) ◽  
pp. 920-929 ◽  
Author(s):  
E Bugge
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Infarct Size ◽  
Rat Heart ◽  
Katp Channels ◽  
Isolated Rat Heart ◽  
Reduce Infarct Size ◽  
Endothelin 1 ◽  
Kinase C ◽  
Isolated Rat

Preconditioning of Isolated Rat Heart Is Mediated by Protein Kinase C

1995 ◽  
Vol 76 (1) ◽  
pp. 73-81 ◽  
Author(s):  
Max B. Mitchell ◽  
Xianzhong Meng ◽  
Lihua Ao ◽  
James M. Brown ◽  
Alden H. Harken ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Rat Heart ◽  
Isolated Rat Heart ◽  
Kinase C ◽  
Isolated Rat

Treatment with Sheng-Mai-San Reduces Myocardial Infarct Size Through Activation of Protein Kinase C and Opening of Mitochondrial KATP Channel

2001 ◽  
Vol 29 (02) ◽  
pp. 367-375 ◽  
Author(s):  
Ningyuan Wang ◽  
Shinya Minatoguchi ◽  
Yoshihiro Uno ◽  
Masazumi Arai ◽  
Kazuaki Hashimoto ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Infarct Size ◽  
Myocardial Infarct ◽  
Katp Channels ◽  
Myocardial Infarct Size ◽  
Mitochondrial Katp Channel ◽  
Kinase C ◽  
Radix Ginseng ◽  
Mitochondrial Katp Channels

Sheng-Mei-San (SMS), a traditional Chinese formulation comprising Radix Ginseng, Radix Ophiopogonis and Fructus Schisandrae, has long been used for more than 700 years for patients with coronary heart disease. We attempted to clarify 1) whether SMS reduces myocardial infarct size, and 2) whether the infarct size-reducing effect of SMS is related to activation of protein kinase C and the opening of the mitochondrial KATP channels in Japanese white rabbits without collateral circulation. The results indicate that three days treatment but not acute treatment with SMS reduces myocardial infarct size through activation of protein kinase C and opening of the mitochondrial KATP channels.

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