Inactivation of GABA receptors by phenoxybenzamine: Effects on GABA-stimulated benzodiazepine binding in the central nervous system

1982 ◽  
Vol 86 (2) ◽  
pp. 259-264 ◽  
Author(s):  
Roger W.J. Smokcum
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Gaba Receptors ◽  
Benzodiazepine Binding ◽  
The Central Nervous System

scholarly journals Potential action on the central nervous system of neroli oil extracted from Citrus aurantium

2021 ◽  
Vol 10 (13) ◽  
pp. e418101321447
Author(s):  
Cassia Aparecida Borba ◽  
Gabriela Vidal Fernandes ◽  
Jaqueline Campos Campos ◽  
Thais Bueno da Silva ◽  
Rodrigo Vieira Gonzaga
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Gaba Receptors ◽  
Antagonistic Activity ◽  
Potential Therapeutic Application ◽  
Physical Disorders ◽  
The Central Nervous System ◽  
Underlying Pathology ◽  
Efficacy Profile ◽  
Neuronal Disorders

The essential oil from C. aurantium has been widely studied due to its potential anxiolytic action on several receptors in the Central Nervous System (CNS). Although it presents variations in its phytochemical composition depending on its origin, we can highlight that many compounds remain present, such as linalool that demonstrated antagonistic activity on glutamatergic receptors, possible inhibitory action of noradrenaline and serotonin receptors, besides the ability to activate GABA receptors in association with some flavonoids present in the oil. It is globally known that the underlying pathology called anxiety influences worldwide as an antecedent of conflicting psychological and physical disorders, which are associated with various neuronal disorders. In this regard, the oil extracted from C. aurantium flowers shows a potential therapeutic application for the treatment of anxiety disorders. However, more studies are needed to elucidate its complete role on the CNS and to verify and prove its safety and efficacy profile.

GABA and GABA Receptors in the Central Nervous System and Other Organs

2002 ◽  
pp. 1-47 ◽  
Author(s):  
Masahito Watanabe ◽  
Kentaro Maemura ◽  
Kiyoto Kanbara ◽  
Takumi Tamayama ◽  
Hana Hayasaki
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Gaba Receptors ◽  
The Central Nervous System

Effects of Hyperoxia on Lung Utrastructure

1970 ◽  
Vol 28 ◽  
pp. 26-27
Author(s):  
Gladys Harrison
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Light Microscopy ◽  
Oxygen Effects ◽  
Age Dependent ◽  
The Central Nervous System ◽  
The Subject ◽  
Space Age ◽  
Alveolar Septa ◽  
Extensive Damage

With the advent of the space age and the need to determine the requirements for a space cabin atmosphere, oxygen effects came into increased importance, even though these effects have been the subject of continuous research for many years. In fact, Priestly initiated oxygen research when in 1775 he published his results of isolating oxygen and described the effects of breathing it on himself and two mice, the only creatures to have had the “privilege” of breathing this “pure air”.Early studies had demonstrated the central nervous system effects at pressures above one atmosphere. Light microscopy revealed extensive damage to the lungs at one atmosphere. These changes which included perivascular and peribronchial edema, focal hemorrhage, rupture of the alveolar septa, and widespread edema, resulted in death of the animal in less than one week. The severity of the symptoms differed between species and was age dependent, with young animals being more resistant.

Sign in / Sign up

Export Citation Format

Share Document