scholarly journals Potential action on the central nervous system of neroli oil extracted from Citrus aurantium

2021 ◽  
Vol 10 (13) ◽  
pp. e418101321447
Author(s):  
Cassia Aparecida Borba ◽  
Gabriela Vidal Fernandes ◽  
Jaqueline Campos Campos ◽  
Thais Bueno da Silva ◽  
Rodrigo Vieira Gonzaga
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Gaba Receptors ◽  
Antagonistic Activity ◽  
Potential Therapeutic Application ◽  
Physical Disorders ◽  
The Central Nervous System ◽  
Underlying Pathology ◽  
Efficacy Profile ◽  
Neuronal Disorders

The essential oil from C. aurantium has been widely studied due to its potential anxiolytic action on several receptors in the Central Nervous System (CNS). Although it presents variations in its phytochemical composition depending on its origin, we can highlight that many compounds remain present, such as linalool that demonstrated antagonistic activity on glutamatergic receptors, possible inhibitory action of noradrenaline and serotonin receptors, besides the ability to activate GABA receptors in association with some flavonoids present in the oil. It is globally known that the underlying pathology called anxiety influences worldwide as an antecedent of conflicting psychological and physical disorders, which are associated with various neuronal disorders. In this regard, the oil extracted from C. aurantium flowers shows a potential therapeutic application for the treatment of anxiety disorders. However, more studies are needed to elucidate its complete role on the CNS and to verify and prove its safety and efficacy profile.

scholarly journals New Insights into ADAMTS Metalloproteases in the Central Nervous System

Biomolecules ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 403 ◽  
Author(s):  
Yamina Mohamedi ◽  
Tania Fontanil ◽  
Teresa Cobo ◽  
Santiago Cal ◽  
Alvaro J. Obaya
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Brain Plasticity ◽  
Axonal Guidance ◽  
Cellular Functions ◽  
Tissue Organization ◽  
The Central Nervous System ◽  
A Disintegrin And Metalloproteinase ◽  
And Migration ◽  
Neuronal Disorders

Components of the extracellular matrix (ECM) are key players in regulating cellular functions throughout the whole organism. In fact, ECM components not only participate in tissue organization but also contribute to processes such as cellular maintenance, proliferation, and migration, as well as to support for various signaling pathways. In the central nervous system (CNS), proteoglycans of the lectican family, such as versican, aggrecan, brevican, and neurocan, are important constituents of the ECM. In recent years, members of this family have been found to be involved in the maintenance of CNS homeostasis and to participate directly in processes such as the organization of perineural nets, the regulation of brain plasticity, CNS development, brain injury repair, axonal guidance, and even the altering of synaptic responses. ADAMTSs are a family of “A disintegrin and metalloproteinase with thrombospondin motifs” proteins that have been found to be involved in a multitude of processes through the degradation of lecticans and other proteoglycans. Recently, alterations in ADAMTS expression and activity have been found to be involved in neuronal disorders such as stroke, neurodegeneration, schizophrenia, and even Alzheimer’s disease, which in turn may suggest their potential use as therapeutic targets. Herein, we summarize the different roles of ADAMTSs in regulating CNS events through interactions and the degradation of ECM components (more specifically, the lectican family of proteoglycans).

scholarly journals Rhinocerebral Murcomycosis: Reflection of the World Diabetes Epidemic

2021 ◽  
Author(s):  
Ruan Matheus Freitas de Castro ◽  
Messias de Lima Macedo ◽  
Rwanielly Freitas de Castro ◽  
Cássia Rozária da Silva Souza ◽  
Leidy Nara Andrade Soares Pereira ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Central Nervous System ◽  
Nervous System ◽  
Healthy Eating ◽  
High Frequency ◽  
Opportunistic Fungi ◽  
The World ◽  
The Central Nervous System ◽  
High Degree ◽  
Underlying Pathology

Introduction: The human body is a structure composed of billions of specialized cells, each activity goes through the control of the Central Nervous System (CNS). Neuroinfections are pathologies that affect the CNS, for example, we have Murcomycosis, a progressive infection caused by opportunistic fungi of the order Mucorales, with high frequency in Immunodepressed patients, Diabetes Mellitus (DM) is the main underlying pathology associated with the development of Rhinocerebral Murcomycosis, which represents 50% of the cases, with a mortality rate of 70% (Sidrim, 2012, p.168). Objective: To highlight the main symptoms associated with Murcomycosis and Diabetes Mellitus. Methodology: Literary review of the Scielo, Shola.google PubMed and library collections, from 2012 to 2021, with the descriptors: Mycosis, Diabetes mellitus and Central Nervous System. Results: It was evidenced that 90% of the diagnosed cases refer to patients with a high degree of immunodepression, mainly due to DM, the main symptoms include unilateral facial pain, headache and fever, frequently resulting in necrosis of the paranasal sinuses. Conclusion: Considering the findings of Murcumicosis associated with DM, it becomes essential to apply informative strategies regarding healthy eating and physical habits, protected by an efficient policy aimed at reducing the incidence of the disease as a basis, the diagnosis of Murcomycosis can be reduced.

GABA and GABA Receptors in the Central Nervous System and Other Organs

2002 ◽  
pp. 1-47 ◽  
Author(s):  
Masahito Watanabe ◽  
Kentaro Maemura ◽  
Kiyoto Kanbara ◽  
Takumi Tamayama ◽  
Hana Hayasaki
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Gaba Receptors ◽  
The Central Nervous System
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