Interleukin-1 receptor antagonist displays intrinsic agonist activity on rat gastric fundus motility in vitro

1995 ◽  
Vol 275 (1) ◽  
pp. 31-37 ◽  
Author(s):  
Paolo Montuschi ◽  
Giuseppe Tringali ◽  
Adriana Mirtella ◽  
Luca Parente ◽  
Paolo Preziosi ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Interleukin 1 ◽  
Gastric Fundus ◽  
Agonist Activity ◽  
Interleukin 1 Receptor Antagonist ◽  
Rat Gastric Fundus

scholarly journals Induction of interleukin-1 and interleukin-1 receptor antagonist during contaminated in-vitro dialysis with whole blood

1996 ◽  
Vol 11 (1) ◽  
pp. 101-108 ◽  
Author(s):  
R. Schindler ◽  
S. Krautzig ◽  
V. Lufft ◽  
G. Lonnemann ◽  
A. Mahiout ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Whole Blood ◽  
Interleukin 1 ◽  
Interleukin 1 Receptor Antagonist

scholarly journals In vitro production of interleukin-1 receptor antagonist in chronic renal failure, CAPD and HD

1992 ◽  
Vol 42 (6) ◽  
pp. 1419-1424 ◽  
Author(s):  
Brian J.G. Pereira ◽  
Debra D. Poutsiaka ◽  
Andrew J. King ◽  
James A. Strom ◽  
Geetha Narayan ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Receptor Antagonist ◽  
Interleukin 1 ◽  
In Vitro Production ◽  
Interleukin 1 Receptor Antagonist ◽  
Vitro Production

Interleukin-1 beta release from rat gastric fundus

1996 ◽  
Vol 271 (2) ◽  
pp. G275-G281 ◽  
Author(s):  
P. Montuschi ◽  
G. Tringali ◽  
A. Mirtella ◽  
L. Parente ◽  
E. Ragazzoni ◽  
...  
Keyword(s):  
Acid Secretion ◽  
Ex Vivo ◽  
Interleukin 1 ◽  
Gastric Fundus ◽  
Interleukin 1 Beta ◽  
Rat Gastric Fundus ◽  
Hypothalamic Level ◽  
Stimulation Of

Interleukin-1 (IL-1) is known to regulate gastric functions via a central action at the hypothalamic level, and it has also been shown that this cytokine can directly modulate rat gastric motility. This study was conducted to determine whether IL-1 beta is produced and released by rat gastric fundi in vitro. IL-1 beta immunoreactivity was released in measurable amounts from explanted rat gastric tissue. This release was not affected by electrical stimulation of the gastric strips or by agents that induce IL-1 biosynthesis. It could be inhibited only by the glucocorticoid dexamethasone. Ex vivo experiments confirmed the inhibitory role of glucocorticoids and showed that IL-1 beta release can be inhibited by agents that reduce gastric acid secretion, suggesting that the latter might stimulate IL-1 beta synthesis and release. In light of the well-established gastroprotection exerted by IL-1, H(+)-induced IL-1 beta release might serve as a protection against mucosal injuries caused by acid secretion, and the inhibition of this release by glucocorticoids might be involved in the pathogenesis of gastric damage associated with severe stress or steroid therapy.

Production of interleukin-1 receptor antagonist by human glioblastoma cells in vitro and in vivo

1994 ◽  
Vol 50 (2) ◽  
pp. 187-194 ◽  
Author(s):  
Mitsuhiro Tada ◽  
Annie-Claire Diserens ◽  
Isabelle Desbaillets ◽  
Rehana Jaufeerally ◽  
Marie-France Hamou ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Interleukin 1 ◽  
Glioblastoma Cells ◽  
Human Glioblastoma ◽  
Interleukin 1 Receptor Antagonist ◽  
Human Glioblastoma Cells

Induction of interleukin-1 and interleukin-1 receptor antagonist during contaminated in-vitro dialysis with whole blood

1996 ◽  
Vol 11 (1) ◽  
pp. 101-108 ◽  
Author(s):  
R. Schindler ◽  
S. Krautzig ◽  
V. Lufft ◽  
G. Lonnemann ◽  
A. Mahiout ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Whole Blood ◽  
Interleukin 1 ◽  
Interleukin 1 Receptor Antagonist
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