The degradation of amino acids, proteins, and blood to short-chain fatty acids in colon is prevented by lactulose

1990 ◽  
Vol 98 (2) ◽  
pp. 353-360 ◽  
Author(s):  
Per Brøbech Mortensen ◽  
Klavs Holtug ◽  
Helen Bonnén ◽  
Mette Rye Clausen
1988 ◽  
Vol 254 (3) ◽  
pp. F407-F416 ◽  
Author(s):  
R. S. Balaban ◽  
L. J. Mandel

The effects of various short-chain fatty acids, carboxylic acids, and amino acids on NADH fluorescence and oxygen consumption (QO2) of rabbit proximal tubule suspensions were determined. The short-chain fatty acids were the most effective substrates in increasing NADH fluorescence and QO2, followed by the carboxylic acids and amino acids. All of the substrates tested that increased NADH fluorescence proportionally increased QO2. This implies that the primary effect of these substrates was to increase QO2 by increasing the delivery of reducing equivalents to NAD and not by stimulating ATP hydrolysis directly. The relative affinity of several substrates to increase NADH fluorescence was also determined. The short-chain fatty acids had the highest affinity (10 microM range) followed by the carboxylic acids (100 microM range). These data demonstrate that the metabolic rate and NADH redox state of the renal cortical cell is very sensitive to the type of metabolic substrate available.


Metabolomics ◽  
2013 ◽  
Vol 9 (4) ◽  
pp. 818-827 ◽  
Author(s):  
Xiaojiao Zheng ◽  
Yunping Qiu ◽  
Wei Zhong ◽  
Sarah Baxter ◽  
Mingming Su ◽  
...  

1994 ◽  
Vol 92 (4) ◽  
pp. 629-635 ◽  
Author(s):  
Mercedes Gallardo ◽  
Paloma Munoz De Rueda ◽  
Angel Jesus Matilla ◽  
Isabel Maria Sanchez-Calle

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 92-OR ◽  
Author(s):  
WEI HUANG ◽  
YONG XU ◽  
YOUHUA XU ◽  
LUPING ZHOU ◽  
CHENLIN GAO

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1898-P
Author(s):  
ADELINA I.L. LANE ◽  
SAVANNA N. WENINGER ◽  
FRANK DUCA

1994 ◽  
Vol 7 (6) ◽  
Author(s):  
U. Siigur ◽  
K. E. Norin ◽  
G. Allgood ◽  
T. Schlagheck ◽  
Tore Midtvedt

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