In vitro binding characteristics of [3H]spiperone to the pituitary of the goldfish (Carassius auratus)

1989 ◽  
Vol 74 (1) ◽  
pp. 57-67 ◽  
Author(s):  
Robert J. Omeljaniuk ◽  
Richard E. Peter
Keyword(s):  
Carassius Auratus ◽  
Binding Characteristics ◽  
In Vitro Binding ◽  
Goldfish Carassius Auratus ◽  
Vitro Binding

In vitro binding characteristics of [3H]AZ11637326, a novel α7-selective neuronal nicotinic receptor agonist radioligand

2010 ◽  
Vol 645 (1-3) ◽  
pp. 63-69 ◽  
Author(s):  
John C. Gordon ◽  
Eifion Phillips ◽  
David A. Gurley ◽  
J. Richard Heys ◽  
Lois Ann Lazor ◽  
...  
Keyword(s):  
Nicotinic Receptor ◽  
Receptor Agonist ◽  
Binding Characteristics ◽  
Neuronal Nicotinic Receptor ◽  
In Vitro Binding ◽  
Vitro Binding

In Vitro Binding Characteristics of a New Selective Group II Metabotropic Glutamate Receptor Radioligand, [3H]LY354740, in Rat Brain

1998 ◽  
Vol 53 (2) ◽  
pp. 228-233 ◽  
Author(s):  
Hervé Schaffhauser ◽  
J. Grayson Richards ◽  
Jayne Cartmell ◽  
Sylvie Chaboz ◽  
John A. Kemp ◽  
...  
Keyword(s):  
Rat Brain ◽  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Binding Characteristics ◽  
Metabotropic Glutamate ◽  
In Vitro Binding ◽  
Vitro Binding ◽  
Group Ii

scholarly journals Fluorinated cannabinoid CB2 receptor ligands: Synthesis and in vitro binding characteristics of 2-oxoquinoline derivatives

2011 ◽  
Vol 19 (18) ◽  
pp. 5698-5707 ◽  
Author(s):  
Nashaat Turkman ◽  
Aleksander Shavrin ◽  
Roman A. Ivanov ◽  
Brian Rabinovich ◽  
Andrei Volgin ◽  
...  
Keyword(s):  
Cb2 Receptor ◽  
Receptor Ligands ◽  
Binding Characteristics ◽  
In Vitro Binding ◽  
Vitro Binding

Discovery of New AKT1 Inhibitors by Combination of In silico Structure Based Virtual Screening Approaches and Biological Evaluations

2019 ◽  
Author(s):  
Filip Fratev ◽  
Denisse A. Gutierrez ◽  
Renato J. Aguilera ◽  
suman sirimulla
Keyword(s):  
Virtual Screening ◽  
Success Rate ◽  
Protein Interactions ◽  
In Silico ◽  
Biological Data ◽  
In Vitro Binding ◽  
Vitro Binding ◽  
Screening Protocol ◽  
Screening Approaches

AKT1 is emerging as a useful target for treating cancer. Herein, we discovered a new set of ligands that inhibit the AKT1, as shown by in vitro binding and cell line studies, using a newly designed virtual screening protocol that combines structure-based pharmacophore and docking screens. Taking together with the biological data, the combination of structure based pharamcophore and docking methods demonstrated reasonable success rate in identifying new inhibitors (60-70%) proving the success of aforementioned approach. A detail analysis of the ligand-protein interactions was performed explaining observed activities.<br>

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