Evidence of an insulin generated pyruvate dehydrogenase stimulating factor in rat brain plasma membranes

1987 ◽  
Vol 19 (10) ◽  
pp. 909-913 ◽  
Author(s):  
M.T. Rinaudo ◽  
M. Curto ◽  
R. Bruno ◽  
C. Marino ◽  
V. Rossetti ◽  
...  
Keyword(s):  
Rat Brain ◽  
Pyruvate Dehydrogenase ◽  
Plasma Membranes ◽  
Stimulating Factor

ACTH SOLUBILIZATION OF A KINASE FROM RAT BRAIN SYNAPTOSOMAL PLASMA MEMBRANES

1981 ◽  
Vol 9 (2) ◽  
pp. 356P-356P
Author(s):  
V. J. Aloyo ◽  
H. Zwiers ◽  
P. R. Bär ◽  
W. H. Gispen
Keyword(s):  
Rat Brain ◽  
Plasma Membranes ◽  
Synaptosomal Plasma Membranes

scholarly journals Effect of phenylpyruvate on pyruvate dehydrogenase activity in rat brain mitochondria

1973 ◽  
Vol 134 (2) ◽  
pp. 539-544 ◽  
Author(s):  
John M. Land ◽  
John B. Clark
Keyword(s):  
Rat Brain ◽  
Dehydrogenase Activity ◽  
Pyruvate Dehydrogenase ◽  
Pyruvate Dehydrogenase Complex ◽  
Competitive Inhibitor ◽  
Brain Mitochondria ◽  
Significant Inhibition ◽  
Complex Activity ◽  
Rat Brain Mitochondria ◽  
Dehydrogenase Complex

1. The effects of phenylpyruvate, a metabolite produced in phenylketonuria, on the pyruvate dehydrogenase-complex activity were investigated in rat brain mitochondria. 2. Pyruvate dehydrogenase activity was measured by two methods, one measuring the release of 14CO2 from [1-14C]pyruvate and the other measuring the acetyl-CoA formed by means of the coupling enzyme, pigeon liver arylamine acetyltransferase (EC 2.3.1.5). In neither case was there significant inhibition of the pyruvate dehydrogenase complex by phenylpyruvate at concentrations below 2mm. 3. However, phenylpyruvate acted as a classical competitive inhibitor of the coupling enzyme arylamine acetyltransferase, with a Ki of 100μm. 4. It was concluded that the inhibition of pyruvate dehydrogenase by phenylpyruvate is unlikely to be a primary enzyme defect in phenylketonuria.

Time-dependent cadmium-neurotoxicity in rat brain synaptosomal plasma membranes

1991 ◽  
Vol 100 (1-2) ◽  
pp. 271-275 ◽  
Author(s):  
C.D. Fasitsas ◽  
S.E. Theocharis ◽  
D. Zoulas ◽  
S. Chrissimou ◽  
G. Deliconstantinos
Keyword(s):  
Rat Brain ◽  
Plasma Membranes ◽  
Time Dependent ◽  
Synaptosomal Plasma Membranes
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