Comparative force-velocity relation and analyses of myosin of dog atria and ventriclesH. Refsum, G. Hollosi, J.-L. Rouleau, L. Chuck, W.W. Parmley, J. Wikman-Coffelt. Institute of Medical Biology, University of Tromsø, Norway, and Cardiovascular Research Institute, University of California, San Francisco, USA

1983 ◽  
Vol 15 ◽  
pp. 53-53
Keyword(s):  
San Francisco ◽  
University Of California ◽  
Cardiovascular Research ◽  
Velocity Relation ◽  
Cardiovascular Research Institute ◽  
Force Velocity ◽  
Research Institute

Persisting patency of the ductus arteriosus in the preterm infant

2021 ◽  
pp. 101-106
Author(s):  
Michael Obladen
Keyword(s):  
Child Health ◽  
San Francisco ◽  
Ductus Arteriosus ◽  
Blood Gas Analysis ◽  
Gas Analysis ◽  
Cyclooxygenase Inhibitors ◽  
Rapid Progress ◽  
Cardiovascular Research ◽  
Cardiovascular Research Institute ◽  
Health And Development

By 1769, it was known to Morgagni that the ductus arteriosus may persist until adulthood. In 1835, Jörg linked delayed postnatal closure with disturbed respiration, a discovery that afterwards was forgotten for a century. When blood gas analysis became available, the association between persisting patency and diminished oxygenation resurfaced. When it became known that prostaglandins played a role in maintaining ductal patency, the development of pharmacologic intervention with cyclooxygenase inhibitors immediately followed. This rapid progress was due to the interaction between basic science, paediatric cardiology, and neonatology disciplines at the Cardiovascular Research Institute in San Francisco, coordinated by Julius Comroe, as well as President Kennedy’s foundation of the National Institute of Child Health and Development. This series of events exemplifies how clinical research became an integrated managed multidisciplinary endeavour in the 20th century.

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