Extracellular concentration of ascorbic acid and catecholamines in the rat striatum during cerebral ischaemia and reperfusion T.P. Obrenovitch, T. Matsumoto, L. Symon. Gough-Cooper Department of Neurological Surgery, Institute of Neurology, London, England

1988 ◽  
Vol 20 ◽  
pp. S26
Keyword(s):  
Ascorbic Acid ◽  
Cerebral Ischaemia ◽  
Rat Striatum ◽  
Extracellular Concentration ◽  
Ischaemia And Reperfusion ◽  
Neurological Surgery

Changes of superoxide dismutase activity and ascorbic acid in focal cerebral ischaemia in rats

1992 ◽  
Vol 14 (1) ◽  
pp. 26-30 ◽  
Author(s):  
Kiyoshi Takagi ◽  
Hideaki Kanemitsu ◽  
Noriko Tomukai ◽  
Hidemune Oka ◽  
Akira Tamura ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Superoxide Dismutase ◽  
Cerebral Ischaemia ◽  
Superoxide Dismutase Activity ◽  
Focal Cerebral Ischaemia

Reduction of Edema and Infarction by Memantine and MK-801 After Focal Cerebral Ischaemia and Reperfusion in Rat

2000 ◽  
Vol 142 (11) ◽  
pp. 1287-1292 ◽  
Author(s):  
A. Görgülü ◽  
T. Kınş ◽  
S. Çobanoğlu ◽  
F. U¨nal ◽  
N. İ zgi ◽  
...  
Keyword(s):  
Cerebral Ischaemia ◽  
Focal Cerebral Ischaemia ◽  
Mk 801 ◽  
Ischaemia And Reperfusion

A dopaminergic mechanism mediates the d-amphetamine- and apomorphine-induced increase of ascorbic acid metabolism in the rat striatum

1990 ◽  
Vol 22 ◽  
pp. 41-42
Author(s):  
M. Miele ◽  
M.S. Desole ◽  
P. Enrico ◽  
G. Esposito ◽  
G. De Natale ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Acid Metabolism ◽  
Rat Striatum ◽  
Dopaminergic Mechanism

Failure of 5-HT3 receptors in regulation of ethanol-induced ascorbic acid release in rat striatum

2001 ◽  
Vol 6 (1) ◽  
pp. 25-34 ◽  
Author(s):  
Chun-Fu Wu ◽  
Jing Liu ◽  
Wen Liu ◽  
Silvana Consolo ◽  
Mei Huang ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Rat Striatum ◽  
Acid Release

Hydroxysafflor Yellow A Reprograms TLR9 Signalling Pathway in Ischaemic Cortex after Cerebral Ischaemia and Reperfusion

2018 ◽  
Vol 17 (5) ◽  
pp. 370-382 ◽  
Author(s):  
Zhe Gong ◽  
Jingrui Pan ◽  
Xiangpen Li ◽  
Hongxuan Wang ◽  
Lei He ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Cerebral Ischaemia ◽  
Glucose Deprivation ◽  
Signalling Pathway ◽  
Neurological Deficits ◽  
Sprague Dawley ◽  
Hydroxysafflor Yellow A ◽  
Ischaemia And Reperfusion ◽  
Anti Inflammatory ◽  
Acute Cerebral Ischaemia

Background and Objective: Hydroxysafflor yellow A (HSYA) was reported to suppress inflammation in ischaemic microglia. However, the mechanism through which HSYA inhibits inflammation caused by cerebral ischaemia and reperfusion injury remains unknown. Here, we have mimicked acute cerebral ischaemia and reperfusion injury by subjecting male Sprague-Dawley rats to transient middle cerebral artery occlusion for 90 minutes and have demonstrated that toll-like receptor 9 (TLR9) was upregulated from day 3 after reperfusion, accompanied by the persistent activation of the pro-inflammatory nuclear factor-κB (NF-κB) pathway from 6 hours to day 7. HSYA was injected intraperitoneally at a dose of 6 mg/kg per day, which activated TLR9 in microglia of ischaemic cortex at 6 hours after reperfusion and then obviously suppressed the NF-κB pathway from day 1 to day 7. Meanwhile, HSYA also activated the anti-inflammatory pathway through interferon regulatory factor 3 from day 1 to day 3. The anti-inflammatory effect of HSYA was partially reversed by TLR9-siRNA interference in primary microglia, which was stimulated by oxygen-glucose deprivation and reoxygenation treatment. The regulation of TLR9-mediated inflammation by HSYA was consistent with the recovery of neurological deficits in rats. Conclusion: Therefore, our findings support that HSYA exerts anti-inflammatory effects by reprogramming the TLR9 signalling pathway during treatment of acute cerebral ischaemia and reperfusion injury.

Differential effects of clozapine on ethanol-induced ascorbic acid release in mouse and rat striatum

2005 ◽  
Vol 380 (1-2) ◽  
pp. 83-87 ◽  
Author(s):  
Yue Hou ◽  
Chun Fu Wu ◽  
Jing Yu Yang ◽  
Ling Tu ◽  
Pei Fei Gu ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Rat Striatum ◽  
Differential Effects ◽  
Acid Release
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