Development of elevated blood pressure in young genetically hypertensive rats

Life Sciences ◽  
1970 ◽  
Vol 9 (5) ◽  
pp. 247-250 ◽  
Author(s):  
D.R. Jones ◽  
D.A. Dowd
Keyword(s):  
Blood Pressure ◽  
Elevated Blood Pressure ◽  
Elevated Blood ◽  
Hypertensive Rats ◽  
Genetically Hypertensive Rats ◽  
Genetically Hypertensive

Blood Pressure in Genetically Hypertensive Rats

Hypertension ◽  
1995 ◽  
Vol 26 (3) ◽  
pp. 452-459 ◽  
Author(s):  
Anne O. Davidson ◽  
Nicholas Schork ◽  
Bryon C. Jaques ◽  
Andrew W. Kelman ◽  
Roger G. Sutcliffe ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Hypertensive Rats ◽  
Genetically Hypertensive Rats ◽  
Genetically Hypertensive

NE turnover in genetically hypertensive rats of Lyon strain. I. Brain nuclei

1988 ◽  
Vol 255 (4) ◽  
pp. H729-H735 ◽  
Author(s):  
M. Sautel ◽  
J. Sacquet ◽  
M. Vincent ◽  
J. Sassard
Keyword(s):  
Blood Pressure ◽  
Hypothalamic Nucleus ◽  
Primary Role ◽  
Hypertensive Rats ◽  
Brain Areas ◽  
Brain Nuclei ◽  
Genetically Hypertensive Rats ◽  
Low Blood Pressure ◽  
Genetically Hypertensive

Several indirect evidences of alterations in the central catecholaminergic structures were obtained in genetically hypertensive rats. Because they could be of pathogenetic value, we measured, in the present work, the in vivo turnover (TO) of norepinephrine (NE) in brain areas of 5- and 22-wk-old genetically hypertensive (LH) rats of the Lyon strain, and their simultaneously selected normotensive (LN) and low blood pressure (LL) controls. Among the changes observed, the increased TO of NE in the A2 and A6 regions of 5-wk-old LH rats and its decrease in the posteroventral hypothalamic nucleus of 22-wk-old LH animals appeared likely to compensate for hypertension. On the contrary, the decreased TO of NE in the anterior hypothalamic nucleus observed at 5 wk and in the A6 and A1 areas at 22 wk of age in LH rats could participate in the development or the maintenance of hypertension. Above all, it was postulated that the increased TO of NE found in the A7 region of 5-wk-old LH rats could play a primary role in the pathogenesis of hypertension in the Lyon model.

Effects of tonin on the response to norepinephrine by the aortic strip of the hypertensive rat

1981 ◽  
Vol 59 (8) ◽  
pp. 790-793 ◽  
Author(s):  
R. Garcia ◽  
E. L. Schiffrin ◽  
G. Thibault ◽  
R. Boucher ◽  
J. Genest
Keyword(s):  
Blood Pressure ◽  
Smooth Muscle ◽  
Elevated Blood Pressure ◽  
Elevated Blood ◽  
Hypertensive Rats ◽  
Aortic Smooth Muscle ◽  
Hypertensive Group ◽  
Aortic Strip ◽  
The One

The response to norepinephrine (NE) of arterial smooth muscle from two types of experimental hypertensive rats was investigated. Aortic strips from one-kidney, one-clip hypertensive animals were less responsive to NE than those from their normotensive controls but strips from two-kidney, one-clip hypertensive animals showed no difference from their corresponding controls. The contractility in response to NE was the same in all groups. These results suggest that the mechanisms responsible for the lesser reactivity in the one-kidney hypertensive group are not a consequence of elevated blood pressure itself but may be related to changes in the intrinsic sensitivity of aortic smooth muscle.Tonin potentiated the contraction induced by NE in aortic strips from hypertensive and normotensive rats. This effect was more pronounced in the one-kidney, one-clip hypertensive animals, so that although the aortic smooth muscle from these animals is less reactive to NE, the decreased reactivity can be more than compensated by the presence of tonin. The mechanism of potentiation is not yet clear but the fact that Saralasin did not inhibit it suggests that angiotensin Il is not generated in situ.

High blood pressure maintenance in transgenic mRen-2 vs. Lyon genetically hypertensive rats

1993 ◽  
Vol 265 (1) ◽  
pp. R180-R186 ◽  
Author(s):  
M. Lo ◽  
I. A. Medeiros ◽  
J. J. Mullins ◽  
D. Ganten ◽  
C. Barres ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Renin Angiotensin System ◽  
Renal Perfusion ◽  
Sodium Reabsorption ◽  
Sprague Dawley ◽  
Hypertensive Rats ◽  
Renal Handling ◽  
Genetically Hypertensive Rats ◽  
Pressure Natriuresis ◽  
Genetically Hypertensive

The present work was aimed to assess the factors involved in the maintenance of hypertension in adult transgenic mRen-2 (TG) rats. Special attention was paid to the renal handling of sodium, the sympathetic, and the renin-angiotensin system (RAS) activity. TG rats were compared with age-matched Lyon genetically hypertensive rats (LH), as both are of Sprague-Dawley origin. Blood pressure (BP), heart rate, and renal sympathetic nerve activity (RSNA) were recorded in conscious freely moving animals. Kidneys were isolated and single-pass perfused at different pressure levels. It was observed that the peripheral sympathetic drive was identical in TG and LH rats as indicated by their similar 24-h urinary excretion of catecholamines and methoxylated metabolites, baseline RSNA and its control by the baroreflex, and hypotensive response to ganglion-blockade. On the contrary, TG rats differed from LH rats by a more rapid excretion of an oral isotonic sodium load, a greater hypotensive and natriuretic response to furosemide, and a more marked BP response to acute RAS blockade. The TG kidney responses to stepwise changes in renal perfusion pressure (RPP) differed from those of LH rats by significantly higher perfusate flow and glomerular filtration rate. However, the pressure natriuresis curve of TG kidneys did not differ from that of LH rats because of an elevated tubular sodium reabsorption rate. These results suggest that adult TG rats, compared with LH rats, exhibit a tendency toward sodium and water retention, which may explain that despite low renal and circulating renin levels, the RAS remains involved in the maintenance of high BP in that model.

Sign in / Sign up

Export Citation Format

Share Document