The in vitro effect of growth hormone on adipose tissue lipoprotein lipase in rats

Life Sciences ◽  
1981 ◽  
Vol 28 (2) ◽  
pp. 199-201 ◽  
Author(s):  
Toshio Murase ◽  
Nobuhiro Yamada ◽  
Fukashi Matsuzaki
Keyword(s):  
Growth Hormone ◽  
Adipose Tissue ◽  
Lipoprotein Lipase ◽  
Adipose Tissue Lipoprotein Lipase ◽  
Vitro Effect

scholarly journals Post-translational regulation of lipoprotein lipase activity in adipose tissue

1978 ◽  
Vol 176 (3) ◽  
pp. 865-872 ◽  
Author(s):  
P Ashby ◽  
D P Bennett ◽  
I M Spencer ◽  
D S Robinson
Keyword(s):  
Adipose Tissue ◽  
Lipoprotein Lipase ◽  
Lipase Activity ◽  
Translational Regulation ◽  
Progressive Increase ◽  
Lipoprotein Lipase Activity ◽  
Dependent Part ◽  
Adipose Tissue Lipoprotein Lipase ◽  
Energy Dependent

Changes in adipose-tissue lipoprotein lipase activity that are independent of protein synthesis were investigated in an incubation system in vitro. Under appropriate conditions at 25 degrees C a progressive increase in the enzyme activity occurs that is energy-dependent. Part of the enzyme is rapidly inactivated when the tissue is incubated with adrenaline or adrenaline plus theophylline. The mechanism of this inactivation appears to be distinct from, and to follow, the activation of the enzyme. A hypothesis is presented to account for the results in terms of an activation of the enzyme during obligatory post-translational processing and a catecholamine-regulated inactivation of the enzyme as an alternative to secretion from the adipocyte.

Interactive in vitro effect of prolactin, growth hormone and season on leptin secretion by ovine adipose tissue

2011 ◽  
Vol 100 (2-3) ◽  
pp. 177-183 ◽  
Author(s):  
M. Szczesna ◽  
D.A. Zieba ◽  
B. Klocek-Gorka ◽  
D.H. Keisler
Keyword(s):  
Growth Hormone ◽  
Adipose Tissue ◽  
Vitro Effect

Reciprocal Changes, Caused by Insulin and Glucagon, of Adipose Tissue Lipoprotein Lipase in Rats In Vitro

1981 ◽  
Vol 13 (04) ◽  
pp. 212-213 ◽  
Author(s):  
T. Murase ◽  
K. Tanaka ◽  
Y. Iwamoto ◽  
Y. Akanuma ◽  
K. Kosaka
Keyword(s):  
Adipose Tissue ◽  
Lipoprotein Lipase ◽  
Adipose Tissue Lipoprotein Lipase

scholarly journals The effect in vitro of high-density lipoprotein on hydrolysis of triacylglycerol by lipoprotein lipase

1981 ◽  
Vol 200 (2) ◽  
pp. 453-456 ◽  
Author(s):  
M P Rogers ◽  
I Hutchinson
Keyword(s):  
Adipose Tissue ◽  
High Density Lipoprotein ◽  
Lipoprotein Lipase ◽  
Bovine Milk ◽  
Density Lipoprotein ◽  
High Density ◽  
Rat Adipose Tissue ◽  
Adipose Tissue Lipoprotein Lipase ◽  
Hydrolysis Of

In an incubation system in vitro with fully activated Intralipid as substrate, rat high-density lipoprotein inhibits the hydrolysis of triacylglycerol by lipoprotein lipase from rat adipose tissue, but does not inhibit hydrolysis by the enzyme from bovine milk. The pattern of inhibition suggests that substrate and high-density lipoprotein may compete for association with rat adipose-tissue lipoprotein lipase.

scholarly journals Effects of insulin, glucocorticoids and adrenaline on the activity of rat adipose-tissue lipoprotein lipase

1980 ◽  
Vol 188 (1) ◽  
pp. 185-192 ◽  
Author(s):  
P Ashby ◽  
D S Robinson
Keyword(s):  
Protein Synthesis ◽  
Adipose Tissue ◽  
Lipoprotein Lipase ◽  
Lipase Activity ◽  
Lipoprotein Lipase Activity ◽  
Fat Bodies ◽  
Rat Adipose Tissue ◽  
Adipose Tissue Lipoprotein Lipase

The lipoprotein lipase activity of epididymal fat-bodies from starved rats was measured during incubations at 37 degrees C in vitro. Protein synthesis independent activation of the enzyme, previously observed during incubations at 25 decrease C, also occurs at 37 degrees C. Protein-synthesis-dependent increases in the activity of the enzyme occur in the presence of insulin and are markedly potentiated by glucocorticoids. The effects on the activity of the enzyme of insulin alone, or in the presence of glucocorticoids, are correlated with its effects on total protein synthesis in the tissue. Adrenaline antagonizes the increase in activity of the enzyme brought about by insulin and abolishes the potentiation of insulin action by glucocorticoids. These changes may be due, at least in part, to its stimulation of inactivation of the enzyme in the tissue. It is suggested that changes in adipose-tissue lipoprotein lipase activity that occur with changes in nutritional status in vivo result from the combined effects of changes in plasma insulin and glucocorticoid concentrations.

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