Participation of opioid receptor types on post-tetanic twitch inhibition in isolated guinea-pig heal longitudinal muscle

1994 ◽  
Vol 33 (5) ◽  
pp. 671-679 ◽  
Author(s):  
M. Ozaki ◽  
Y. Miyamoto ◽  
S. Kishioka ◽  
Y. Masuda ◽  
H. Yamamoto
Keyword(s):  
Guinea Pig ◽  
Opioid Receptor ◽  
Longitudinal Muscle ◽  
Opioid Receptor Types

scholarly journals Participation of opioid receptor subtypes in post-tetanic twitch inhibition of isolated guinea-pig ileal longitudinal muscle.

1991 ◽  
Vol 55 ◽  
pp. 393
Author(s):  
Masanobu Ozaki ◽  
Yoshiyuki Miyamoto ◽  
Shiroh Kishioka ◽  
Tetsuji Yamanishi ◽  
Yuji Kitabata ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Opioid Receptor ◽  
Longitudinal Muscle ◽  
Receptor Subtypes ◽  
Opioid Receptor Subtypes

Investigations into the mechanism of morphine and ethanol inhibition in the guinea pig ileum longitudinal muscle strip

1980 ◽  
Vol 58 (3) ◽  
pp. 265-270 ◽  
Author(s):  
John G. Clement
Keyword(s):  
Guinea Pig ◽  
Muscarinic Receptors ◽  
Longitudinal Muscle ◽  
Opiate Receptor ◽  
Muscle Strip ◽  
Ethanol Inhibition ◽  
Twitch Response ◽  
Mechanism Of Inhibition ◽  
Ethanol Ethanol ◽  
A Site

It has been noted that the analgesic property of ethanol bears a marked resemblance to that of morphine. The purpose of this study was to determine if the mechanism of action of morphine and ethanol was similar using the guinea pig ileal longitudinal muscle strip (GPI-LMS). Ethanol (35–260 mM) depressed the twitch response and the acetylcholine- (ACh-), KCl-, and BaCl2-induced contractions to the same extent while having no significant effect on the binding of [3H]quinuclidinyl benzilate ([3H]QNB) to muscarinic receptors. Morphine (53–530 nM) inhibited the twitch response and to a lesser extent BaCl2- and KCl-induced contractions while having no significant effect on either ACh-induced contractions or the binding of [3H]QNB to muscarinic receptors. Naloxone and increased [Ca2+] reversed the inhibitory effects of morphine but not ethanol. Ethanol appears to inhibit a site after interaction of ACh with the receptor. Mechanism of inhibition of BaCl2 response is also different as naloxone and increased [Ca2+] reverse morphine but not ethanol inhibition. Ethanol inhibition in GPI-LMS does not involve the opiate receptor.

A Subtype of κ-Opioid Receptor Mediates Inhibition of High-Affinity GTPase Inherent in Gi1 in Guinea Pig Cerebellar Membranes

2002 ◽  
Vol 66 (2) ◽  
pp. 845-851 ◽  
Author(s):  
Hiroshi Ueda ◽  
Hidemi Misawa ◽  
Nobuyuki Fukushima ◽  
Toshiaki Katada ◽  
Michio Ui ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Opioid Receptor ◽  
High Affinity
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