Spectrophotometric determination of the protolytic dissociation constants of the new chromogenic reagent “palladiazo”—IInvestigations with sodium hydroxide, perchloric acid and different aqueous buffer solutions

Talanta ◽  
1971 ◽  
Vol 18 (2) ◽  
pp. 183-211 ◽  
Author(s):  
J.A. Pérez-Butsamante ◽  
F. Burriel-Martí
Keyword(s):  
Sodium Hydroxide ◽  
Spectrophotometric Determination ◽  
Perchloric Acid ◽  
Dissociation Constants ◽  
Aqueous Buffer ◽  
Chromogenic Reagent ◽  
Buffer Solutions

Collaborative Study of the Spectrophotometric Determination of Procainamide Hydrochloride

1976 ◽  
Vol 59 (4) ◽  
pp. 807-810
Author(s):  
Jeffrey C Hamm
Keyword(s):  
Sodium Hydroxide ◽  
Acid Medium ◽  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Collaborative Study ◽  
Dosage Forms ◽  
Standard Deviations

Abstract The USP analysis for procainamide HCl is titrimetric and relatively nonspecific, capsule and tablet dyes may interfere, and the method is not applicable to coated tablets. In the spectrophotofluorometric method the sample deteriorates when exposed to a xenon source. In the ultraviolet spectrophotometric method reported here, the sample is dispersed in acid medium, possible interferences are extracted in chloroform, base is added, procainamide is extracted in chloroform, the residue is dissolved in sodium hydroxide, and the compound is measured by absorption at 272 nm and comparison with a standard. Recoveries of standards added to capsule, tablet, and injection composites ranged from 99.3 to 102%. Twelve collaborators reported duplicate assay results for all 3 dosage forms with per cent standard deviations for 5 samples ranging from 1.01 to 1.27%. The method has been adopted as official first action.

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