Optical properties of dimedonyl derivative of aromatic amines and amino acids

The kinetic and optical properties of Co(II)-substituted pyruvate kinase in the presence of D-phenylalanine (D-Phe) were investigated. The results are discussed in comparison with the effects of its optical isomer L-phenylalanine (L-Phe) on the same enzyme. The catalytic effect of D-Phe on rabbit muscle pyruvate kinase depended upon the nature of the activating divalent metal ion used. It has stimulatory effect on Mg(II)-activated enzyme, but inhibitory effect on Co(II)-activated enzyme. Unlike the inhibitory effect of L-Phe, the inhibition of Co(II)–enzyme by D-Phe was not sensitive to the changes of pH and temperature, could not be reversed by L-alanine (L-Ala), displayed hyperbolic kinetics, and was noncompetitive with respect to phosphoenolpyruvate saturation. D-Phe induced substantial visible circular dichroism (CD) spectral changes of Co(II)–enzyme similar to those induced by L-Phe. Although ultraviolet CD spectrum was not affected, D-Phe induced an ultraviolet difference absorption spectral change very similar to, but much smaller than, that induced by L-Phe. Our results support that D-Phe and other amino acids interact with the enzyme at two different sites: a common site, causing similar conformational changes which bear little direct kinetic relevance, and a kinetically relevant site, which is sterically dependent upon the side chain of the amino acids.

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Role of the tosyl group in the coordination ability of N-protected amino acids. 3. Ternary complexes of copper(II) with N-tosylglycine and aromatic amines. Crystal and molecular structure of bis(N-tosylglycinato)bis(N-methylimidazole)copper(II)

Inorganic Chemistry ◽

10.1021/ic00155a016 ◽

1983 ◽

Vol 22 (13) ◽

pp. 1902-1906 ◽

Cited By ~ 18

Author(s):

L. P. Battaglia ◽

A. Bonamartini Corradi ◽

G. Marcotrigiano ◽

L. Menabue ◽

G. C. Pellacani

Keyword(s):

Molecular Structure ◽

Amino Acids ◽

Aromatic Amines ◽

Crystal And Molecular Structure ◽

Ternary Complexes ◽

Tosyl Group ◽

Coordination Ability

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Physisorption of amino acids on TiO2: Changes in the nonlinear optical properties

Journal of Computational Methods in Sciences and Engineering ◽

10.3233/jcm-160668 ◽

2017 ◽

Vol 17 (1) ◽

pp. 127-137

Author(s):

Emildo Marcano ◽

José Gregorio Cisneros ◽

Johana Alayón ◽

Juan Murgich

Keyword(s):

Amino Acids ◽

Optical Properties ◽

Nonlinear Optical ◽

Nonlinear Optical Properties

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Highly Fluorescent Peri -functionalized Perylenemonoimide Derivatives with Tunable Optical Properties for Selective Sensing of Electron-rich Aromatic Amines

ChemistrySelect ◽

10.1002/slct.201702368 ◽

2017 ◽

Vol 2 (35) ◽

pp. 11747-11754 ◽

Cited By ~ 6

Author(s):

Vikas Sharma ◽

Dhananjaya Sahoo ◽

Falguni Chandra ◽

Apurba L. Koner

Keyword(s):

Optical Properties ◽

Aromatic Amines ◽

Tunable Optical Properties

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Reaction of dopa decarboxylase with L-aromatic amino acids under aerobic and anaerobic conditions

Biochemical Journal ◽

10.1042/bj3520533 ◽

2000 ◽

Vol 352 (2) ◽

pp. 533-538 ◽

Cited By ~ 13

Author(s):

Mariarita BERTOLDI ◽

Carla BORRI VOLTATTORNI

Keyword(s):

Amino Acids ◽

Aromatic Amines ◽

Aromatic Amino Acids ◽

Product Formation ◽

Enzyme Concentration ◽

Dopa Decarboxylase ◽

Decarboxylase Activity ◽

Anaerobic Conditions ◽

Experimental Conditions ◽

Reaction Specificity

Analysis of the reaction of dopa decarboxylase (DDC) with L-dopa reveals that loss of decarboxylase activity with time is observed at enzyme concentrations approximately equal to the binding constant, Kd, of the enzyme for pyridoxal 5ƀ-phosphate (PLP). Instead, at enzyme concentrations higher than Kd the course of product formation proceeds linearly until complete consumption of the substrate. Evidence is provided that under both experimental conditions no pyridoxamine 5ƀ-phosphate (PMP) is formed during the reaction and that dissociation of coenzyme occurs at low enzyme concentration, leading to the formation of a PLP-L-dopa Pictet–Spengler cyclic adduct. Taken together, these results indicate that decarboxylation-dependent transamination does not accompany the decarboxylation of L-dopa proposed previously [O'Leary and Baughn (1977) J. Biol. Chem. 252, 7168–7173]. Nevertheless, when the reaction of DDC with L-dopa is studied under anaerobic conditions at an enzyme concentration higher than Kd, we observe that (1) the enzyme is gradually inactivated and inactivation is associated with PMP formation and (2) the initial velocity of decarboxylation is approximately half of that in the presence of O2. Similar behaviour is observed by comparing the reaction with L-5-hydroxytryptophan occurring in aerobiosis or in anaerobiosis. Therefore the reaction of DDC with L-aromatic amino acids seems to be under O2 control. In contrast, the reactivity of the enzyme with D-aromatic amino acids does not change in the presence or absence of O2. These and other results, together with previous results on the effect exerted by O2 on reaction specificity of DDC towards aromatic amines [Bertoldi, Frigeri, Paci and Borri Voltattorni (1999) J. Biol. Chem. 274, 5514–5521], suggest a productive effect of O2 on an intermediate complex of the reaction of the enzyme with L-aromatic amino acids or aromatic amines.

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Roles of Tobacco Fractions in the Formation of Polycyclic Aromatic Amines in Tobacco Pyrolysis

Beiträge zur Tabakforschung International/Contributions to Tobacco Research ◽

10.2478/cttr-2013-0936 ◽

2013 ◽

Vol 25 (6) ◽

pp. 595-606

Author(s):

S Yoshida ◽

K Kobayashi

Keyword(s):

Amino Acids ◽

Aromatic Amines ◽

Methylene Chloride ◽

Soluble Fraction ◽

Inorganic Ions ◽

Insoluble Residue ◽

Target Temperature ◽

Carrier Gas ◽

Polycyclic Aromatic

AbstractThe aim of the present study was to gain further understanding of the precursors in tobacco of four polycyclic aromatic amines (PAAs) - 1- and 2-aminonaphthalene, 3- and 4-aminobiphenyl. We carried out non-isothermal pyrolysis of the residues, which were obtained after extraction of tobacco cut filler with methylene chloride followed by extraction with water, under three different pyrolysis conditions (target temperature 800 °C / 800 °C / 400 °C and O2 concentration in carrier gas 0% / 20% / 3%, resp.). The yields of the four PAAs obtained by the pyrolysis of each sample were evaluated. Several nitrogenous components in the sample were also analyzed. The results under all these pyrolysis conditions showed that 1) the methylene chloride-soluble fraction, in which 50-60% of nicotine was extracted, did NOT contribute significantly contribution to the yields of the four PAAs; 2) the watersoluble fraction, in which most of the nitrogenous inorganic ions and amino acids were extracted, contributed at an average of about 30% to total PAA yield; and 3) the insoluble residue, in which only protein was detected during the investigation of the nitrogenous components in the present study, showed the highest contribution, 50-60% of the four PAAs formed. Consequently, it is concluded that protein-like components in tobacco contribute highly to the formation of the four PAAs by tobacco pyrolysis.

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Facile and Sensitive Detection of Nitrogen-Containing Organic Bases with Near Infrared C-Dots Derived Assays

Nanomaterials ◽

10.3390/nano11102607 ◽

2021 ◽

Vol 11 (10) ◽

pp. 2607

Author(s):

Chunyu Ji ◽

Yiqun Zhou ◽

Wenquan Shi ◽

Jiajia Wu ◽

Qiurui Han ◽

...

Keyword(s):

Amino Acids ◽

Aromatic Amines ◽

Near Infrared ◽

Limit Of Detection ◽

High Reliability ◽

Sensitive Detection ◽

Test Paper ◽

Organic Bases ◽

Fused Ring ◽

Sulfur Containing

In this article, we have designed both colorimetric (including solution and test paper type) and spectral sensors (including UV-vis and PL type) for the quick and sensitive detection of general nitrogen-containing organic bases (NCOBs); the limit of detection could reach as low as 0.50 nM. NCOBs included 11 examples, covering aliphatic and aromatic amines, five- and six-membered heterocyclics, fused-ring heterocyclics, amino acids, and antibiotics. Furthermore, the assays demonstrated high reliability in sensing NCOBs and excellent ability to distinguish NCOBs from oxygen and sulfur containing organics. The assays developed could find important applications for the detection of NCOBs in the fields of biomedicine, chemistry, and agriculture.

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