A study of some of the pharmacologic actions of fentanyl citrate and droperidol

Background:More than half of the patients attending emergency centers need analgesics. Injectable analgesics are currently the most common pain control strategy, but entail complications. Fentanyl is one of the most commonly used pain-relief opiates available in various forms.Objective:The present study aims to compare analgesic effects of nebulized against intravenous fentanyl for controlling pain due to limb fracture.Method:The present double-blind clinical trial recruited 213 patients presenting with fractured limbs to emergency departments. The first group of patients received 1 micg/kg of intravenous fentanyl citrate from a solution of 50 micg/ml and 5 ml of normal saline in nebulized form (group A), and the second group intravenously received 5 ml of normal saline and 4 micg/kg of 50 micg/ml solution of fentanyl citrate in nebulized form, whose volume reached 5 ml with the addition of normal saline (group B). Then, pain level was frequently measured and compared in the two groups for 20 minutes.Results:The results obtained showed reduced pain level in both the groups. However, point-by-point comparison of pain in the two groups revealed significantly greater pain reduction in intravenous fentanyl group (P<0.001). The need for adjuvant pain relief medication was 8.3% in intravenous fentanyl group and 24% in nebulized fentanyl group, with a significant difference between the two groups (P=0.002).Conclusion:According to the results, although nebulized fentanyl is effective in controlling pain due to limb fracture, it was less effective than intravenous type, and unable to control pain in many cases.

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Salvadora persica: Nature’s Gift for Periodontal Health

Antioxidants ◽

10.3390/antiox10050712 ◽

2021 ◽

Vol 10 (5) ◽

pp. 712

Author(s):

Mohamed Mekhemar ◽

Mathias Geib ◽

Manoj Kumar ◽

Radha ◽

Yasmine Hassan ◽

...

Keyword(s):

Clinical Trials ◽

Periodontal Therapy ◽

Periodontal Treatment ◽

Oral Disease ◽

Salvadora Persica ◽

Periodontal Health ◽

Clinical Investigations ◽

Therapeutic Mechanisms ◽

Pharmacologic Actions

Salvadora persica (SP) extract, displays very valuable biotherapeutic capacities such as antimicrobial, antioxidant, antiparasitic and anti-inflammatory effects. Numerous investigations have studied the pharmacologic actions of SP in oral disease therapies but its promising outcomes in periodontal health and treatment are not yet entirely described. The current study has been planned to analyze the reported effects of SP as a support to periodontal therapy to indorse regeneration and healing. In consort with clinical trials, in vitro investigations show the advantageous outcomes of SP adjunctive to periodontal treatment. Yet, comprehensive supplementary preclinical and clinical investigations at molecular and cellular levels are indispensable to reveal the exact therapeutic mechanisms of SP and its elements for periodontal health and therapy.

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535 COMPARATIVE BIOAVAILABILITY OF FENTANYL EFFERVESCENT BUCCAL TABLET (FEBT) AND ORAL TRANSMUCOSAL FENTANYL CITRATE (OTFC®)

European Journal of Pain ◽

10.1016/s1090-3801(06)60538-7 ◽

2006 ◽

Vol 10 (S1) ◽

pp. S141a-S141

Author(s):

M. Darwish ◽

M. Kirby ◽

P. Robertson ◽

W. Tracewell ◽

J.G. Jiang

Keyword(s):

Fentanyl Citrate ◽

Oral Transmucosal Fentanyl Citrate ◽

Buccal Tablet ◽

Comparative Bioavailability

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SELF-TREATMENT WITH ORAL TRANSMUCOSAL FENTANYL CITRATE TO PREVENT EMERGENCY ROOM VISITS

Pain Medicine ◽

10.1046/j.1526-4637.2002.202433.x ◽

2002 ◽

Vol 3 (2) ◽

pp. 186.2-187

Keyword(s):

Emergency Room ◽

Emergency Room Visits ◽

Fentanyl Citrate ◽

Oral Transmucosal Fentanyl Citrate

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Oral transmucosal fentanyl citrate for the treatment of breakthrough pain in cancer patients: An overview of its pharmacological and clinical characteristics

American Journal of Hospice and Palliative Medicine® ◽

10.1177/104990910502200313 ◽

2005 ◽

Vol 22 (3) ◽

pp. 228-232 ◽

Cited By ~ 17

Author(s):

Kyriaki Mystakidou ◽

Emmanuela Katsouda ◽

Efi Parpa ◽

Marinos L. Tsiatas ◽

Lambros Vlahos

Keyword(s):

Cancer Patients ◽

Clinical Characteristics ◽

Breakthrough Pain ◽

Fentanyl Citrate ◽

Oral Transmucosal Fentanyl Citrate

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Pain Intensity after Laseruvulopalatoplasty and Tonsillectomy

Otolaryngology ◽

10.1067/mhn.2003.82 ◽

2003 ◽

Vol 128 (2) ◽

pp. 273-279 ◽

Cited By ~ 12

Author(s):

Hannu Kokki ◽

Elina Nikanne ◽

Mikko Aho ◽

Jukka Virtaniemi

Keyword(s):

Pain Relief ◽

Pain Intensity ◽

Pain Treatment ◽

Antiinflammatory Drug ◽

Nonsteroidal Antiinflammatory Drug ◽

Free Access ◽

Fentanyl Citrate ◽

Rescue Analgesia ◽

Parallel Group ◽

At Home

OBJECTIVE: The first objective of this study was to evaluate pain intensity and opioid consumption during the first 24 hours after uvulopalatoplasty and tonsillectomy in the hospital, and the second was to evaluate pain intensity and its progression during the first 2 weeks after surgery at home. STUDY DESIGN AND SETTINGS: In a prospective parallel group study, 51 patients with uvulopalatoplasty or tonsillectomy were studied. Ketoprofen, a nonsteroidal antiinflammatory drug, and fentanyl citrate, an opioid, were used as analgesics. RESULTS: Despite ketoprofen infusion and free access to a patient-controlled pump with fentanyl citrate for rescue analgesia, inadequate pain relief was common both after uvulopalatoplasty (35%) and after tonsillectomy (28%) during the first 24 hours after surgery. The consumption of fentanyl citrate was similar after both operations. At home, pain intensity was highest in the mornings during the first 5 days, and 10 patients had some pain still after 2 weeks. Also at home, high pain scores were reported commonly in both groups. CONCLUSION: Sgnificant pain after uvulopalatoplasty and tonsillectomy lasted for several days. Ketoprofen in the commercial capsule form proved to be too short acting for overnight pain relief. SIGNIFICANCE: Pain treatment in patients with uvulopalatoplasty and tonsillectomy should be improved to allow patients a peaceful recovery after surgery.

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