Monoclonal antibody to SV40 T-antigen blocks lysis of cloned cytotoxic T-cell line specific for SV40 TASA

Virology ◽  
1983 ◽  
Vol 125 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Suelhua Pan ◽  
Barbara B. Knowles
Keyword(s):  
Monoclonal Antibody ◽  
T Cell ◽  
Cell Line ◽  
T Antigen ◽  
Cytotoxic T Cell ◽  
Sv40 T Antigen

scholarly journals Characterization of human T cells reactive with the Mycoplasma arthritidis-derived superantigen (MAM): generation of a monoclonal antibody against V beta 17, the T cell receptor gene product expressed by a large fraction of MAM-reactive human T cells.

1991 ◽  
Vol 174 (4) ◽  
pp. 891-900 ◽  
Author(s):  
S M Friedman ◽  
M K Crow ◽  
J R Tumang ◽  
M Tumang ◽  
Y Q Xu ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
T Cells ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Activity ◽  
Cell Receptor ◽  
Cytotoxic T Cell ◽  
Mycoplasma Arthritidis ◽  
Human T Cells

While all known microbial superantigens are mitogenic for human peripheral blood lymphocytes (PBL), the functional response induced by Mycoplasma arthritidis-derived superantigen (MAM) is unique in that MAM stimulation of PBL consistently results in T cell-dependent B cell activation characterized by polyclonal IgM and IgG production. These immunostimulatory effects of MAM on the humoral arm of the human immune system warranted a more precise characterization of MAM-reactive human T cells. Using an uncloned MAM reactive human T cell line as immunogen, we have generated a monoclonal antibody (mAb) (termed C1) specific for the T cell receptor V beta gene expressed by the major fraction of MAM-reactive human T cells, V beta 17. In addition, a V beta 17- MAM-reactive T cell population exists, assessed by MAM, induced T cell proliferation and cytotoxic T cell activity. mAb C1 will be useful in characterizing the functional properties of V beta 17+ T cells and their potential role in autoimmune disease.

Participation of a dominant cytotoxic T cell population defined by a monoclonal antibody in syngeneic anti-tumor responses

1990 ◽  
Vol 20 (9) ◽  
pp. 2095-2103 ◽  
Author(s):  
Yuji Matsubayashi ◽  
Toshiyasu Hirama ◽  
Atsuo Morioka ◽  
Michihiro Iwashiro ◽  
Tohru Masuda ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
T Cell ◽  
Cell Population ◽  
Cytotoxic T Cell

scholarly journals Efficient Eradication of Subcutaneous but Not of Autochthonous Gastric Tumors by Adoptive T Cell Transfer in an SV40 T Antigen Mouse Model

2010 ◽  
Vol 185 (4) ◽  
pp. 2580-2588 ◽  
Author(s):  
Carole Bourquin ◽  
Philip von der Borch ◽  
Christine Zoglmeier ◽  
David Anz ◽  
Nadja Sandholzer ◽  
...  
Keyword(s):  
T Cell ◽  
Mouse Model ◽  
T Antigen ◽  
Cell Transfer ◽  
Sv40 T Antigen ◽  
Adoptive T Cell Transfer ◽  
Gastric Tumors ◽  
T Cell Transfer

Suppression of P2- T cell line-mediated experimental autoimmune neuritis by interleukin-2 receptor targeted monoclonal antibody ART 18

1989 ◽  
Vol 489 (1) ◽  
pp. 120-128 ◽  
Author(s):  
Hans-Peter Hartung ◽  
Ba¨rbel Scha¨fer ◽  
Tibor Diamanststein ◽  
Walter Fierz ◽  
Kurt Heininger ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
T Cell ◽  
Cell Line ◽  
Interleukin 2 ◽  
Experimental Autoimmune Neuritis ◽  
Interleukin 2 Receptor ◽  
Experimental Autoimmune

Functional Pancreatic  -Cell Line From SV40 T-Antigen Transgenic Mouse

Diabetes ◽  
1989 ◽  
Vol 38 (8) ◽  
pp. 1056-1062 ◽  
Author(s):  
A. Gilligan ◽  
L. Jewett ◽  
D. Simon ◽  
I. Damjanov ◽  
F. M. Matschinsky ◽  
...  
Keyword(s):  
Cell Line ◽  
Transgenic Mouse ◽  
T Antigen ◽  
Sv40 T Antigen ◽  
Pancreatic Cell

Establishment and characterization of a SV40 T-antigen immortalized human bronchial epithelial cell line

1992 ◽  
Vol 28 (7-8) ◽  
pp. 461-464 ◽  
Author(s):  
Joan H. Schiller ◽  
Chinghai Kao ◽  
Gerard Bittner ◽  
Chuck Harris ◽  
Terry D. Oberley ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cell Line ◽  
Bronchial Epithelial Cell ◽  
T Antigen ◽  
Human Bronchial Epithelial Cell ◽  
Epithelial Cell Line ◽  
Sv40 T Antigen ◽  
Bronchial Epithelial

A novel stromal cell-dependent hematopoietic cell line established from temperature-sensitive SV40 T-antigen transgenic mice

1999 ◽  
Vol 27 (6) ◽  
pp. 1087-1096 ◽  
Author(s):  
Nobuaki Yanai ◽  
Naoko Matsui ◽  
Ken-Ichi Matsuda ◽  
Tadashi Furusawa ◽  
Tadashi Okubo ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Cell Line ◽  
Stromal Cell ◽  
T Antigen ◽  
Hematopoietic Cell ◽  
Temperature Sensitive ◽  
Sv40 T Antigen ◽  
Hematopoietic Cell Line
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