Incidence of Epstein-Barr virus bcl-2 expression and chromosomal translocation t(14;18) in large cell lymphoma associated with paragranuloma (lymphocyte-predominant Hodgkin's disease)

1994 ◽  
Vol 25 (3) ◽  
pp. 240-243 ◽  
Author(s):  
M.-L. Hansmann ◽  
D. Shibata ◽  
J. Lorenzen ◽  
K. Hell ◽  
B.N. Nathwani ◽  
...  
Keyword(s):  
Hodgkin's Disease ◽  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
Hodgkin’S Disease ◽  
Chromosomal Translocation ◽  
Large Cell ◽  
Barr Virus ◽  
Large Cell Lymphoma ◽  
Epstein Barr

Epstein–Barr Virus-Associated Anaplastic Large Cell Lymphoma in Renal Transplant Patients

1992 ◽  
Vol 98 (3) ◽  
pp. 312-318 ◽  
Author(s):  
Bettina Borisch ◽  
Kevin C. Gatter ◽  
Andreas Tobler ◽  
L. Theilkäs ◽  
Christopher Bunch ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Anaplastic Large Cell Lymphoma ◽  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
Large Cell ◽  
Barr Virus ◽  
Transplant Patients ◽  
Large Cell Lymphoma ◽  
Renal Transplant Patients ◽  
Epstein Barr

scholarly journals In situ demonstration of Epstein-Barr virus small RNAs (EBER 1) in acquired immunodeficiency syndrome-related lymphomas: correlation with tumor morphology and primary site

Blood ◽  
1993 ◽  
Vol 82 (2) ◽  
pp. 619-624 ◽  
Author(s):  
SJ Hamilton-Dutoit ◽  
M Raphael ◽  
J Audouin ◽  
J Diebold ◽  
I Lisse ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Hodgkin's Disease ◽  
Epstein Barr Virus ◽  
Hodgkin’S Disease ◽  
Large Cell ◽  
Barr Virus ◽  
Acquired Immunodeficiency ◽  
Epstein Barr ◽  
Immunodeficiency Syndrome

Abstract Some acquired immunodeficiency syndrome (AIDS)-related lymphomas (ARLs) are infected with Epstein-Barr virus (EBV), although the frequency and importance of this association is disputed. Using paraffin section RNA in situ hybridization (ISH) with digoxigenin-labeled riboprobes, we screened 16 central nervous system (CNS) non-Hodgkin's lymphomas (NHLs), 101 systemic NHLs, and 11 Hodgkin's disease cases arising in human immunodeficiency virus-seropositive individuals for EBV-encoded small RNA (EBER 1) expression, an EBV gene product transcribed in abundance during latent infection. Tumor cells contained EBV in 85 of 128 ARLs (66%), but infection rates differed with lymphoma type. EBER 1 was expressed in tumor cells in 11 of 11 Hodgkin's disease cases (100%), 15 of 16 CNS NHLs (94%), and 46 of 60 systemic immunoblast- rich/large-cell lymphomas (77%), but in only 12 of 35 Burkitt-type (small noncleaved cell) (34%) and 1 of 6 monomorphic centroblastic (diffuse large noncleaved cell) (17%) lymphomas. In most EBV-positive ARLs, all recognizable viable tumor cells expressed EBER 1. We conclude that (1) EBV infects tumor cells in all AIDS-related Hodgkin's disease cases, in virtually all primary CNS ARLs, and in most systemic immunoblast-rich/large-cell ARLs; (2) only a minority of Burkitt-type and monomorphic centroblastic lymphomas are associated with EBV; and (3) EBER-ISH is ideal for the histopathologic detection of latent EBV in routine tissue specimens.

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