Activation of blood coagulation and fibrinolysis in diabetes mellitus: Evaluation by plasma levels of thrombin-antithrombin III complex and plasmin-alpha 2-plasmin inhibitor complex

1989 ◽  
Vol 55 (6) ◽  
pp. 727-735 ◽  
Author(s):  
Hoyu Takahashi ◽  
Akiko Tsuda ◽  
Wataru Tatewaki ◽  
Ken Wada ◽  
Hiroe Niwano ◽  
...  
1993 ◽  
Vol 4 (2) ◽  
pp. 116-120
Author(s):  
Hiroo ONDA ◽  
Akiteru TOKUNAGA ◽  
Hiroshi TOMA ◽  
Masayoshi SANADA ◽  
Kazue TAKAI

1978 ◽  
Vol 40 (02) ◽  
pp. 532-541 ◽  
Author(s):  
Anders Lagrelius ◽  
Nils-Olov Lunell ◽  
Margareta Blombäck

SummaryThe aim of the present study was to investigate the effect on blood coagulation and fibrinolysis of a natural oestrogen preparation, piperazine oestrone sulphate, prospectively in menopausal women. Scopolamine was given to the control group.The women were investigated before and during treatment with regard to factors VIII, VII, X, V, fibrinopeptide A, antithrombin III, plasminogen, rapid antiplasmin and α1-antitrypsin. There was no significant change towards hypercoagulability or decreased fibrinolysis in any group. In the oestrogen group, however, a tendency towards an increased level of plasminogen and a decreased level of antiplasmin was demonstrated. In the scopolamine group there was an unexpected fall in factors X and V and also in plasminogen and α1,-antitrypsin. A low level of some blood coagulation factors in some of the women before treatment is somewhat astonishing; none of them had any history of excessive bleeding.


1984 ◽  
Vol 52 (02) ◽  
pp. 138-143 ◽  
Author(s):  
M Christe ◽  
J Fritschi ◽  
B Lämmle ◽  
T H Tran ◽  
G A Marbet ◽  
...  

SummaryFifteen haemostasis parameters have been measured in 48 normal persons, 36 diabetics without and 44 with complications and 27 with peripheral arterial disease. Since the patients groups are older than normals, part of the differences are due to age. However, the differences are significant between normals and patients. They become highly significant for the diabetics with complications and nephropathy (Table 7). In diabetics without complications factor VIII functions, fibrinogen and thrombin time are related to age whereas there is a negative correlation for the fibrinolytic activity and antithrombin III. The diabetic complications shade off the correlations, which subsist only for VIIIR: CoF, VIIIR: Ag, ATIII and lysis before stasis. With Hbalc as dependent variable VIIIR:CoF is the only significant predictor variable in diabetics (Table 9).


2001 ◽  
Vol 43 (2) ◽  
pp. 166-168
Author(s):  
Tatsuro Nobutoki ◽  
Takashi Nakano ◽  
Junya Takahashi ◽  
Kazuo Higuchi ◽  
Toshiaki Ihara ◽  
...  

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