Activation of Blood Coagulation and Fibrinolysis in Selected Disease States Assessed by Plasma Levels of Thrombin-Antithrombin III Complex and Plasmin-α2-Plasmin Inhibitor Complex

SummaryThe aim of the present study was to investigate the effect on blood coagulation and fibrinolysis of a natural oestrogen preparation, piperazine oestrone sulphate, prospectively in menopausal women. Scopolamine was given to the control group.The women were investigated before and during treatment with regard to factors VIII, VII, X, V, fibrinopeptide A, antithrombin III, plasminogen, rapid antiplasmin and α1-antitrypsin. There was no significant change towards hypercoagulability or decreased fibrinolysis in any group. In the oestrogen group, however, a tendency towards an increased level of plasminogen and a decreased level of antiplasmin was demonstrated. In the scopolamine group there was an unexpected fall in factors X and V and also in plasminogen and α1,-antitrypsin. A low level of some blood coagulation factors in some of the women before treatment is somewhat astonishing; none of them had any history of excessive bleeding.

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Acute disseminated encephalomyelitis in a boy with elevated plasma levels of thrombin-antithrombin III complex

Pediatrics International ◽

10.1046/j.1442-200x.2001.01355.x ◽

2001 ◽

Vol 43 (2) ◽

pp. 166-168

Author(s):

Tatsuro Nobutoki ◽

Takashi Nakano ◽

Junya Takahashi ◽

Kazuo Higuchi ◽

Toshiaki Ihara ◽

...

Keyword(s):

Plasma Levels ◽

Antithrombin Iii ◽

Acute Disseminated Encephalomyelitis ◽

Elevated Plasma ◽

Thrombin Antithrombin Iii Complex

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Prothrombin fragment 1+2 and thrombin???antithrombin III complex as markers of activation of blood coagulation in inflammatory bowel diseases

European Journal of Gastroenterology & Hepatology ◽

10.1097/00042737-199512000-00010 ◽

1995 ◽

Vol 12 (7) ◽

pp. 1183-1188 ◽

Cited By ~ 44

Author(s):

Patrick Chamouard ◽

Lelia Grunebaum ◽

Marie-Louise Wiesel ◽

Pierre Louis Frey ◽

Christian Wittersheim ◽

...

Keyword(s):

Blood Coagulation ◽

Inflammatory Bowel Diseases ◽

Antithrombin Iii ◽

Prothrombin Fragment ◽

Bowel Diseases ◽

Inflammatory Bowel ◽

Thrombin Antithrombin Iii Complex

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New neonatal problems of blood coagulation and fibrinolysis. I. The change of plasmin inhibitor levels in the newborn infant

Journal of Perinatal Medicine ◽

10.1515/jpme.1976.4.4.213 ◽

1976 ◽

Vol 4 (4) ◽

pp. 213-220 ◽

Cited By ~ 2

Author(s):

S. Suzuki ◽

N. Wake ◽

K. Yoshiaki

Keyword(s):

Blood Coagulation ◽

Newborn Infant ◽

Neonatal Problems ◽

Plasmin Inhibitor ◽

Coagulation And Fibrinolysis

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Haemostatic Activation before and after Surgery in Patients with and without Gastric Malignancy

Thrombosis and Haemostasis ◽

10.1055/s-0038-1642510 ◽

1994 ◽

Vol 71 (05) ◽

pp. 713-718 ◽

Cited By ~ 15

Author(s):

H B Rahr ◽

J V Sørensen ◽

J F Larsen ◽

F Svendsen Jensen ◽

C Bredahl ◽

...

Keyword(s):

Plasma Levels ◽

Malignant Disease ◽

Antithrombin Iii ◽

Degradation Products ◽

Gastric Surgery ◽

Before And After ◽

Discharge From Hospital ◽

Thrombin Antithrombin Iii Complex ◽

Late Postoperative Period ◽

Gastric Malignancy

SummaryPre- and postoperative plasma levels of Prothrombin Fragment 1 + 2 (F1+2), Thrombin-antithrombin III complex (TAT), Fibrinopeptide A (FpA), Fibrin and Fibrinogen Degradation Products (FbDP, FgDP) and Soluble Fibrin (SF) were measured in 40 patients undergoing gastric surgery in order to compare patients operated for benign (n = 21) and malignant (n = 19) disease. Plasma levels of F1+2, TAT, FbDP and SF on the first postoperative day were significantly higher than before operation. F1+2 and FbDP levels were further increased one week after surgery, at which time FgDP levels were also higher than preoperatively. A significant postoperative increase in FpA levels was found only in patients with malignant disease. When age was taken into consideration, significant differences between patients with and without malignancy were found only in the late postoperative period, as cancer patients had higher FpA and FbDP levels one week after surgery and higher FbDP levels one month after discharge from hospital.

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