Regional localization of the antagonism of amphetamine-induced hyperactivity by intracerebral calcitonin injections

1987 ◽  
Vol 27 (1) ◽  
pp. 183-186 ◽  
Author(s):  
Renaud de Beaurepaire ◽  
William J. Freed
Keyword(s):  
Regional Localization

scholarly journals Knock-In Mice with NOP-eGFP Receptors Identify Receptor Cellular and Regional Localization

2015 ◽  
Vol 35 (33) ◽  
pp. 11682-11693 ◽  
Author(s):  
Akihiko Ozawa ◽  
Gloria Brunori ◽  
Daniela Mercatelli ◽  
Jinhua Wu ◽  
Andrea Cippitelli ◽  
...  
Keyword(s):  
Regional Localization

scholarly journals Enhanced resolution of histochemical distribution of glucose-6-phosphate dehydrogenase activity in rat neural tissue by use of a semipermeable membrane.

1991 ◽  
Vol 39 (7) ◽  
pp. 937-943 ◽  
Author(s):  
M A Philbert ◽  
C M Beiswanger ◽  
T L Roscoe ◽  
D K Waters ◽  
H E Lowndes
Keyword(s):  
Vestibular Nucleus ◽  
Neural Tissue ◽  
Semipermeable Membrane ◽  
G6pd Activity ◽  
Ependymal Cells ◽  
Regional Localization ◽  
Enhanced Resolution ◽  
Membrane Technique ◽  
Glucose 6 Phosphate Dehydrogenase ◽  
The Brain

We examined the histochemical distribution of glucose-6-phosphate dehydrogenase (G6PD) activity in neural tissue using different diffusion barriers. Although polyvinyl alcohol and agar overlays permitted regional localization of G6PD, a semipermeable membrane revealed cellular differences in G6PD activity within populations of neurons. Distribution of G6PD activity in selected regions of the nervous system was examined using the membrane technique. White matter usually exhibited strong G6PD activity. The neuronal somata of the dorsal root ganglia (L4-L6) and anterior horns of the spinal lumbar enlargement demonstrated a variation in activity which was independent of somal size. Satellite cells showed intense activity when the membrane technique was used. Hippocampal pyramidal and granular cells of the dentate gyrus exhibited moderate, uniform G6PD activity, but only weak activity was seen in hippocampal and dentate molecular layers. High levels of activity were observed in the vascular endothelial cells of the brain, spinal cord, and choroid plexus, and in the ependymal cells of the spinal central canal and ventricles of the brain. The superior vestibular nucleus appeared to have little G6PD activity in either the neuron cell bodies or the surrounding parenchyma. The use of a semipermeable membrane for localization of G6PD activity in neural tissues permits enhanced resolution of neuron elements and may provide a more accurate assessment of G6PD activity in histological preparations.

Acetylcholinesterase (AChE) and pseudocholinesterase (BuChE) activity distribution pattern in early developing chick limbs

Development ◽  
1985 ◽  
Vol 86 (1) ◽  
pp. 89-108
Author(s):  
Carla Falugi ◽  
Margherita Raineri
Keyword(s):  
Plasma Membrane ◽  
Basal Lamina ◽  
Ache Activity ◽  
Quantitative Methods ◽  
Mesenchymal Cell ◽  
Mesenchymal Cells ◽  
Regional Localization ◽  
Stage Of Development ◽  
Limb Morphogenesis ◽  
Cell Processes

The distribution of acetylcholinesterase (AChE) and pseudocholinesterase (BuChE) activities was studied by histochemical, quantitative and electrophoretical methods during the early development of chick limbs, from stage 16 to stage 32 H.H. (Hamburger & Hamilton, 1951). By quantitative methods, true AChE activity was found, and increased about threefold during the developmental period, together with a smaller amount of BuChE which increased more rapidly in comparison with the AChE activity from stage 25 to 32 H.H. Cholinesterase activity was histochemically localized mainly in interacting tissues, such as the ectoderm (including the apical ectodermal ridge) and the underlying mesenchyme. True AChE was histochemically localized around the nuclei and on the plasma membrane of ectodermal (including AER) and mesenchymal cells, and at the plasma membrane of mesenchymal cell processes reaching the basal lamina between the ectoderm and the mesenchyme. AChE together with BuChE activity was found in the basal lamina between the ectoderm and the mesenchyme, in underlying mesenchymal cells and in deeper mesenchymal cells, especially during their transformation into unexpressed chondrocytes. During limb morphogenesis, the cellular and regional localization of the enzyme activities showed variations depending on the stage of development and on the occurrence of interactions. The possibility of morphogenetic functions of the enzyme is discussed.

Regional localization of the genes coding for human AC02, ARSA, and NAGA on chromosome 22

1980 ◽  
Vol 28 (3) ◽  
pp. 169-172 ◽  
Author(s):  
Geurts van Kessel ◽  
W. Wesrveld ◽  
P.G. de Groot ◽  
Meera Khan ◽  
A. Hagemeijer
Keyword(s):  
Chromosome 22 ◽  
Regional Localization

scholarly journals Regional Localization of the Automotive Industry in the Czech Republic

2012 ◽  
Vol 20 (2) ◽  
pp. 21-39
Author(s):  
Milan Damborský ◽  
Gabriela Říhová ◽  
Vojtěch Rajtr
Keyword(s):  
Czech Republic ◽  
Automotive Industry ◽  
Regional Localization ◽  
The Czech Republic

Using convolutional neural network and long short time memory to automatically detect aneurysm on 2D DSA images (Preprint)

2021 ◽  
Author(s):  
JunHua Liao ◽  
LunXin Liu ◽  
HaiHan Duan ◽  
YunZhi Huang ◽  
LiangXue Zhou ◽  
...  
Keyword(s):  
Deep Learning ◽  
Intracranial Aneurysm ◽  
Spatial Information ◽  
Diagnostic System ◽  
Two Stage ◽  
Regional Localization ◽  
Detection Stage ◽  
Aneurysm Detection ◽  
Sensitivity Specificity ◽  
Computation Load

BACKGROUND It is hard to distinguish cerebral aneurysm from overlap vessels based on the 2D DSA images, for its lack the spatial information. OBJECTIVE The aim of this study is to construct a deep learning diagnostic system to improve the ability of detecting the PCoA aneurysm on 2D-DSA images and validate the efficiency of deep learning diagnostic system in 2D-DSA aneurysm detecting. METHODS We proposed a two stage detecting system. First, we established the regional localization stage (RLS) to automatically locate specific detection region of raw 2D-DSA sequences. And then, in the intracranial aneurysm detection stage (IADS) ,we build three different frames, RetinaNet, RetinaNet+LSTM, Bi-input+RetinaNet+LSTM, to detect the aneurysms. Each of the frame had fivefold cross-validation scheme. The area under curve (AUC), the receiver operating characteristic (ROC) curve, and mean average precision (mAP) were used to validate the efficiency of different frames. The sensitivity, specificity and accuracy were used to identify the ability of different frames. RESULTS 255 patients with PCoA aneurysms and 20 patients without aneurysm were included in this study. The best results of AUC of the RetinaNet, RetinaNet+LSTM, and Bi-input+RetinaNet+LSTM were 0.95, 0.96, and 0.97, respectively. The sensitivity of the RetinaNet, RetinaNet+LSTM, and Bi-input+RetinaNet+LSTM were 81.65% (59.40% to 94.76%), 87.91% (64.24% to 98.27%), 84.50% (69.57% to 93.97%), respectively. The specificity of the RetinaNet, RetinaNet+LSTM, and Bi-input+RetinaNet+LSTM were 88.89% (66.73% to 98.41%), 88.12% (66.06% to 98.08%), and 88.50% (74.44% to 96.39%), respectively. The accuracy of the RetinaNet, RetinaNet+LSTM, and Bi-input+RetinaNet+LSTM were 92.71% (71.29% to 99.54%), 89.42% (68.13% to 98.49%), and 91.00% (77.63% to 97.72%), respectively. CONCLUSIONS Two stage aneurysm detecting system can reduce time cost and the computation load. According to our results, more spatial and temporal information can help improve the performance of the frames, so that Bi-input+RetinaNet+LSTM has the best performance compared to other frames. And our study can demonstrate that our system was feasible to assist doctor to detect intracranial aneurysm on 2D-DSA images.

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