The metastatic cell: Behaviour and biochemistry

Rab11-FIP1 is a Rab effector protein that is involved in endosomal recycling and trafficking of various molecules throughout the endocytic compartments of the cell. The consequence of this can be increased secretion or increased membrane expression of those molecules. In general, expression of Rab11-FIP1 coincides with more tumourigenic and metastatic cell behaviour. Rab11-FIP1 can work in concert with oncogenes such as mutant p53, but has also been speculated to be an oncogene in its own right. In this perspective, we will discuss and speculate upon our observations that mutant p53 promotes Rab11-FIP1 function to not only promote invasive behaviour, but also chemoresistance by regulating a multitude of different proteins.

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Nitric oxide and metastatic cell behaviour

BioEssays ◽

10.1002/bies.20324 ◽

2005 ◽

Vol 27 (12) ◽

pp. 1228-1238 ◽

Cited By ~ 36

Author(s):

Emma L. Williams ◽

Mustafa B.A. Djamgoz

Keyword(s):

Nitric Oxide ◽

Cell Behaviour ◽

Metastatic Cell

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Airway dendritic cell behaviour is influenced by neuropeptide release from sensory nerves

Pneumologie ◽

10.1055/s-0031-1296155 ◽

2011 ◽

Vol 65 (12) ◽

Author(s):

S Voedisch ◽

S Rochlitzer ◽

E Spies ◽

A Braun

Keyword(s):

Dendritic Cell ◽

Sensory Nerves ◽

Cell Behaviour ◽

Neuropeptide Release

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Correlating cell morphology and osteoid mineralization relative to strain profile for bone tissue engineering applications

Journal of The Royal Society Interface ◽

10.1098/rsif.2007.1265 ◽

2007 ◽

Vol 5 (25) ◽

pp. 899-907 ◽

Cited By ~ 4

Author(s):

M.A Wood ◽

Y Yang ◽

E Baas ◽

D.O Meredith ◽

R.G Richards ◽

...

Keyword(s):

Tissue Engineering ◽

Bone Tissue Engineering ◽

Bone Tissue ◽

Cell Morphology ◽

Bone Cells ◽

Calcium Deposition ◽

Cell Behaviour ◽

Local Strains ◽

Strain Profile ◽

Pore Model

A number of bone tissue engineering strategies use porous three-dimensional scaffolds in combination with bioreactor regimes. The ability to understand cell behaviour relative to strain profile will allow for the effects of mechanical conditioning in bone tissue engineering to be realized and optimized. We have designed a model system to investigate the effects of strain profile on bone cell behaviour. This simplified model has been designed with a view to providing insight into the types of strain distribution occurring across a single pore of a scaffold subjected to perfusion–compression conditioning. Local strains were calculated at the surface of the pore model using finite-element analysis. Scanning electron microscopy was used in secondary electron mode to identify cell morphology within the pore relative to local strains, while backscattered electron detection in combination with X-ray microanalysis was used to identify calcium deposition. Morphology was altered according to the level of strain experienced by bone cells, where cells subjected to compressive strains (up to 0.61%) appeared extremely rounded while those experiencing zero and tensile strain (up to 0.81%) were well spread. Osteoid mineralization was similarly shown to be dose dependent with respect to substrate strain within the pore model, with the highest level of calcium deposition identified in the intermediate zones of tension/compression.

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Thermal Physics and Glaucoma II: Preliminary Evidences for a Thermophysical Design of a Possible Visible-Light-Photons Therapy

Applied Sciences ◽

10.3390/app11146301 ◽

2021 ◽

Vol 11 (14) ◽

pp. 6301

Author(s):

Giulia Grisolia ◽

Mariarosa Astori ◽

Antonio Ponzetto ◽

Antonio Vercesi ◽

Umberto Lucia

Keyword(s):

Quality Of Life ◽

Thermodynamic Approach ◽

Equilibrium Thermodynamic ◽

Pharmacological Treatments ◽

Light Stimulation ◽

Cell Behaviour ◽

Thermal Physics ◽

Starting Point

Recently, a non-equilibrium thermodynamic approach has been developed in order to model the fundamental role of the membrane electric potential in the cell behaviour. A related new viewpoint is introduced, with a design of a photobiomodulation treatment in order to restore part of the visual field. Here, a first step in experimental evidence of the validity of the thermodynamic approach is developed. This result represents the starting point for future experimental improvements for light stimulation in order to improve the quality of life of the patients. The future possible therapy will be in addition to the pharmacological treatments.

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